Abstract
A novel grafted copolymer was synthesized from carboxymethyl cellulose (CMC) and carboxymethyl polyvinyl alcohol (CMPVA) using adipic dihydrazide as the crosslinker. The optimized grafted CMC-g-CMPVA with formulation 3% CMC and 1% CMPVA is sensitive to different pH conditions and exhibited a high swelling capacity. The swelling percentages were 360, 1440 and 2277% at pH 1, 7 and 11, respectively and could retain the shape of the hydrogel that assists easy handling. This smart copolymer forms a hydrogel that is pH responsive that could be utilized in the specific pH environment such as in waste water management, agricultural industry, and drug delivery system. The grafted CMC-g-CMPVA was found to be biocompatible with the living cells and has excellent survival rate at lower polymer concentration and, therefore, this grafted copolymer can be employed in biomedical applications such as drug delivery system and scaffolds in the tissue engineering.
Similar content being viewed by others
References
El Sayed A (2014) Nucl Instrum Methods B, 321:41–48
Singh B, Pal L (2011) Int J Biol Macromol 48:501–510
Yang S, Fu S, Liu H, Zhou Y, Li X (2011) J Appl Polym Sci 119:1204–1210
Vieira RS, Guibal E, Silva EA, Beppu MM (2007) Adsorption 13:603–611
Dahlan NA, Ng SL, Pushpamalar J (2017) J Appl Polym Sci 134:44271
Shankar P, Gomathi T, Vijayalakshmi K, Sudha PN (2014) Int J Biol Macromol 67:180–188
Badwaik HR, Sakure K, Alexander A, Ajazuddin H, Dhongade DK, Tripathi (2016) Int J Biol Macromol 85:361–369
Biswal DR, Singh RP (2004) Carbohydr Polym 57:379–387
Pushpamalar V, Langford SJ, Ahmad M, Lim YY (2006) Carbohydr Polym 64:312–318
El-Sayed S, Mahmoud K, Fatah A, Hassen A (2011) Physica B 406:4068–4076
Islam MR, Beg MD, Gupta A (2013) Bioresources 8:3753–3770
Zhang L, Zhang G, Lu J, Liang H (2013) Polym Plast Technol Eng 52:163–167
Agarwal S, Sadegh H, Monajjemi M, Hamdy AS, Ali GAM, Memar AOH, Shahryari-Ghoshekandi R, Tyagi I, Gupta VK (2016) J Mol Liq 218:191–197
El-Salmawi KM, Zaid MMA, Ibraheim SM, El-Naggar AM, Zahran AH (2001) J Appl Polym Sci 82:136–142
Qin Y, Hu H, Luo A, Wang Y, Huang X, Song P (2006) J Appl Polym Sci 99:3110–3115
Yu C, Li B (2008) Polym Compos 29:998–1005
Bao Y, Ma J, Li N (2011) Carbohydr Polym 84:76–82
Liang R, Yuan H, Xi G, Zhou Q (2009) Carbohydr Polym 77:181–187
Bocourt M, Bada N, Acosta N, Bucio E, Peniche C (2014) Polym Int 63:1715–1723
Pushpamalar V, Langford SJ, Ahmad M, Hashim K, Lim YY (2013) J Appl Polym Sci 128:1828–1833
Yang Z, Yuan B, Huang X, Zhou J, Cai J, Yang H, Li A, Cheng R (2012) Water Res 46:107–114
Liu L, Liu D, Wang M, Du G, Chen J (2007) Eur Polym J 43:2672–2681
Bubb WA (2003) Concepts Magn Reson A 19:1–19
Bugada DC, Rudin A (1984) Polymer 25:1759–1766
Kaith B, Kalia S (2007) Int J Polym Anal Charact 12:401–412
Gupta B, Büchi FN, Scherer GG, Chapiro A (1994) Polym Adv Technol 5:493–498
Kaur I, Ray P (2008) Broader spectrum: examples, polymer grafting and crosslinking. Wiley, New York
Anjali T (2012) Carbohydr Polym 87:457–460
Li W, Sun B, Wu P (2009) Carbohydr Polym 78:454–461
Łojewska J, Miśkowiec P, Łojewski T, Proniewicz L (2005) Polym Degrad Stab 88:512–520
Birla R (2014) Introduction to tissue engineering: applications and challenges. Wiley, New York
Acknowledgements
Thanks to Dr. Peters Nichols for running the sample for the solid-state NMR at Monash University Australia. Our valuable gratitude to Dr. Alan Yiu Wah Lee from School of Pharmacy, Monash University Malaysia for providing the brain cells. The study is funded by School of Science, Monash University Malaysia as Honours studentship fund.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dahlan, N.A., Pushpamalar, J., Veeramachineni, A.K. et al. Smart Hydrogel of Carboxymethyl Cellulose Grafted Carboxymethyl Polyvinyl Alcohol and Properties Studied for Future Material Applications. J Polym Environ 26, 2061–2071 (2018). https://doi.org/10.1007/s10924-017-1105-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10924-017-1105-3