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Design and synthesis of novel 6-substituted quinazoline-2-thiols

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Abstract

A novel design and efficient protocol for the synthesis of new class of 6-substituted quinazoline-2-thiols is reported. The derivatization of the thioquinazolines is achieved in a strategic manner using 2-aminobenzylamine. The functionalization of the aniline followed by construction of the heterocyclic ring provides a facile way to synthesize these bifunctional quinazolines.

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Acknowledgements

One of the authors (PSK) is thankful to the Jawaharlal Nehru Technological University, Kakinada, and GITAM University, Hyderabad, for providing laboratory and other facilities.

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Authors and Affiliations

  1. Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh, 533 003, India

    Satya Karuna Pulakhandam

  2. Department of Chemistry, GITAM School of Technology, GITAM Deemed to be University, HTP Campus, Rudraram, Medak, Telangana, 502 329, India

    Naresh Kumar Katari

  3. School of Chemistry and Physics, University of KwaZulu-Natal, P Bag X 54001, Durban, 4000, South Africa

    Naresh Kumar Katari & Sreekantha B. Jonnalagadda

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  1. Satya Karuna Pulakhandam
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Correspondence to Naresh Kumar Katari or Sreekantha B. Jonnalagadda.

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Pulakhandam, S.K., Katari, N.K. & Jonnalagadda, S.B. Design and synthesis of novel 6-substituted quinazoline-2-thiols. Mol Divers 23, 351–360 (2019). https://doi.org/10.1007/s11030-018-9874-8

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