Skip to main content
SpringerLink
Log in

Diffusion transport in interpolyelectrolyte matrix systems based on chitosan and Eudragit L100

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

With a view to the development of new controlled drug delivery systems, the formation of an interpolyelectrolyte complex (IPEC) between chitosan (CTS) and Eudragit L100 (L-100) has been studied. The structure of this IPEC is such that two maxima are observed in the curves of IPEC swelling in the media with different pH values. The release of a model drug (ibuprofen) from IPEC-based tablets is significantly retarded, and this delay can be controlled by changing the molecular weight of CTS in the IPEC composition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. R. Friend, Adv. Drug Deliv. Rev., 7, 149–199 (1991).

    Article  CAS  Google Scholar 

  2. H. Brondsted and J. Kopecek, Pharm. Res., 9, 1540–1545 (1992).

    Article  CAS  PubMed  Google Scholar 

  3. R. Kinget, W. Kalala, L. Vervoort and G. Van den Mooter, J. Drug Targeting, 6(2), 129–149 (1998).

    Article  CAS  Google Scholar 

  4. G. Van den Mooter, C. Samyn, and R. Kinget, Int. J. Pharm., 87, 37–46 (1992).

    Article  Google Scholar 

  5. L. Vervoort, G. Van den Mooter, P. Augustijns and R. Kinget, Int. J. Pharm., 172, 127–135 (1998).

    Article  CAS  Google Scholar 

  6. A. Rubinstein, D. Nakar, and A. Sintov, Int. J. Pharm., 84, 141–150 (1992).

    Article  CAS  Google Scholar 

  7. M. Ashford, J. Fell, D. Attwood, et al., J. Control. Release, 30, 225–232 (1994).

    Article  CAS  Google Scholar 

  8. T. Anthonsen, Chitin and Chitosan: Sources, Chemistry, Biochemistry, Physical Properties and Application, Elsevier, New York (1990).

    Google Scholar 

  9. A. M. Dubinskaya and A. E. Dobrotvorskii, Khim.-Farm. Zh., 23(5), 623–625 (1987).

    Google Scholar 

  10. M. L. Lorenzo-Lamoza, C. Remuňán-Lopez, J. L. Vila-Jato, and M. J. Alonso, J. Control. Release, 52, 109–118 (1998).

    Article  Google Scholar 

  11. A. B. Zezin and V. B. Rogacheva, in: Advances in the Physics and Chemistry of Polymers [in Russia], Khimiya, Moscow (1973), pp. 3–30.

    Google Scholar 

  12. V. A. Kemenova, R. I. Mustafin, K. V. Alekseev, et al., Farmatsiya, No. 1, 67–72 (1991).

  13. R. I. Mustafin and I. M. Zakharov, Khim.-Farm. Zh., 38(8), 46–48 (2004).

    Google Scholar 

  14. V. A. Kemenova, Author’s Abstract of Doctoral (Ph. D. Chem. Sci.) Thesis [in Russian], Moscow (1992).

Download references

Author information

Authors and Affiliations

  1. Kazan Medical University, Kazan, Tatarstan, Russia

    R. I. Mustafin & A. A. Protasova

  2. Leuven Catholic University, Leuven, Belgium

    G. Van den Mooter

  3. All-Russia Institute of Medicinal and Aromatic Plants, Scientific Center for Biomedical Technologies, Moscow, Russia

    V. A. Kemenova

Authors
  1. R. I. Mustafin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Protasova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Van den Mooter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. A. Kemenova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 44–46, December, 2005.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mustafin, R.I., Protasova, A.A., Van den Mooter, G. et al. Diffusion transport in interpolyelectrolyte matrix systems based on chitosan and Eudragit L100. Pharm Chem J 39, 663–666 (2005). https://doi.org/10.1007/s11094-006-0042-6

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-006-0042-6

Keywords

Search

Navigation