Abstract
The third artificial intelligence (AI) boom is coming, and there is an inkling that the speed of its evolution is quickly increasing. In games like chess, shogi, and go, AI has already defeated human champions, and the fact that it is able to achieve autonomous driving is also being realized. Under these circumstances, AI has evolved and diversified at a remarkable pace in medical diagnosis, especially in diagnostic imaging. Therefore, this commentary focuses on AI in medical diagnostic imaging and explains the recent development trends and practical applications of computer-aided detection/diagnosis using artificial intelligence, especially deep learning technology, as well as some topics surrounding it.
Similar content being viewed by others
Notes
On December 6, 2018, approval for the software to determine if it is a neoplastic polyp or not with possibility shown as a number in the super-magnifying endoscope was freshly obtained, based on the Pharmaceuticals and Medical Devices Law in Japan. Support vector machine (SVM) type machine learning instead of deep learning is used in this system.
The American College of Radiology (ACR) Data Science Institute (DSI) has created a new resource for radiology researchers. A complete list of AI algorithms cleared by the FDA related to medical imaging, published on the ACR DSI website, is said to be updated regularly. https://www.acrdsi.org/DSI-Services/FDA-Cleared-AI-Algorithms
References
von Ginneken B. Fifty years of computer analysis in chest imaging: rule-based, machine learning, deep learning. Radiol Phys Technol. 2017;10(1):23–322.
Suzuki K. Overview of deep learning in medical imaging. Radiol Phys Technol. 2017;10(3):257–73.
Shen D, Wu G, Suk H. Deep learning in medical image analysis. Annu Rev Biomed Eng. 2017;19:221–48.
Ker J, Wang L, Rao J, Lim T. Deep learning applications in medical image analysis. IEEE Access. 2018;6:9375–89.
Sahiner B, Pezeshk A, Hadjiiski LM, Wang X, Drukker K, Cha KH, Summers RM, Giger ML. Deep learning in medical imaging and radiation therapy. Med Phys. 2019;46(1):e1–e36.
Soffer S, Ben-Cohen A, Shimon O, Amitai MM, Greenspan H, Klang E. Convolutional neural networks for radiologic images: a radiologist’s guide. Radiology. 2019;290(3):590–606.
Kaji S, Kida S. Overview of image-to-image translation by use of deep neural networks: denoising, super-resolution, modality conversion, and reconstruction in medical imaging. Radiol Phys Technol. 2019;12(3):235–48.
Hwang JJ, Jung YH, Cho BH, Heo MS. An overview of deep learning in the field of dentistry. Imaging Sci Dent. 2019;49(1):1–7.
Lee G, Fujita H. Deep learning in medical image analysis: challenges and applications. Cham: Springer; 2020 (in press).
Doi K. Computer-aided diagnosis in medical imaging: historical review, current status and future potential. Comput Med Imaging Graph. 2007;31(4–5):198–21111.
Gao Y, Geras KJ, Lewin AA, Moy L. New frontiers: an update on computer-aided diagnosis for breast imaging in the age of artificial intelligence. AJR Am J Roentgenol. 2019;212:300–7.
Freer TW, Ulissey MJ. Screening mammography with computer aided detection: prospective study of 12,860 patients in a community breast center. Radiology. 2001;220(3):781–6.
Fenton JJ, Taplin SH, Carney PA, Abraham L, Sickles EA, D'Orsi C, Berns EA, Cutter G, Hendrick RE, Barlow WE, Elmore JG. Influence of computer-aided detection on performance of screening mammography. N Engl J Med. 2007;356(14):1399–409.
Lehman CD, Wellman RD, Buist DS, Kerlikowske K, Tosteson AN, Miglioretti DL. Breast cancer surveillance consortium. Diagnostic accuracy of digital screening mammography with and without computer-aided detection. JAMA Intern Med. 2015;175(11):1828–37.
Kobli A, Jha S. Why CAD failed in mammography. J Am Coll Radiol. 2018;15(3):535–7.
Zhou X, Takayama R, Wang S, Hara T, Fujita H. Deep learning of the sectional appearances of 3D CT images for anatomical structure segmentation based on an FCN voting method. Med Phys. 2017;44(10):5221–333.
Faes L, Wagner SK, Fu DJ, Liu X, Korot E, Ledsam JR, Back T, Chopra R, Pontikos N, Kern C, Moraes G, Schmid MK, Sim D, Balaskas K, Bachmann LM, Denniston AK, Keane PA. Automated deep learning design for medical image classification by health-care professionals with no coding experience: a feasibility study. Lancet Digit Health. 2019;1(5):e232–e242242.
Wang X, Peng Y, Lu L, Lu Z, Bagheri M, Summers RM. ChestX-ray8: hospital-scale chest X-ray database and benchmarks on weakly-supervised classification and localization of common thorax diseases. In: 2017 IEEE conference on computer vision and pattern recognition (CVPR). Honolulu: IEEE; 2017. p. 2097–106. https://doi.org/10.1109/CVPR.2017.369, http://openaccess.thecvf.com/content_cvpr_2017/papers/Wang_ChestX-ray8_Hospital-Scale_Chest_CVPR_2017_paper.pdf.
https://nihcc.app.box.com/v/DeepLesion. Accessed 28 Dec 2019.
https://stanfordmlgroup.github.io/competitions/chexpert/. Accessed 28 Dec 2019.
Dunnmon J, Yi D, Langlots CP, Ré C, Rubin DL, Lungren MP. Assessment of convolutional neural networks for automated classification of chest radiographs. Radiology. 2019;290(2):537–44.
Abdelhafiz D, Yang C, Ammar R, Nabavi S. Deep convolutional neural networks for mammography: advances, challenges and applications. BMC Bioinform. 2019;20(Suppl 11):281.
https://www.cancerimagingarchive.net/. Accessed 28 Dec 2019.
Huynh BQ, Li H, Giger ML. Digital mammographic tumor classification using transfer learning from deep convolutional neural networks. J Med Imaging. 2016;3(3):034501.
Samala RK, Chan HP, Hadjiiski L, Helvie MA, Wei J, Cha K. Mass detection in digital breast tomosynthesis: deep convolutional neural network with transfer learning from mammography. Med Phys. 2016;43:6654–66.
Kim M, Lee H, Song K, Sehyo Y, Ramaraj P, Lee C, Baik J, Do S. GrayNet: a versatile base model for practical deep learning CT applications. In: Proc. of Conference on Machine Intelligence in Medical Imaging (C-MIMI), 2-page extended abstract is available from C-MIMI 2019 website, Austin, TX, Sep. 22–23, 2019.
https://github.com/MGH-LMIC/graynet_keras. Accessed 28 Dec 2019.
https://devblogs.nvidia.com/annotation-transfer-learning-clara-train/. Accessed 28 Dec 2019.
Yi X, Walia E, Babyn P. Generative adversarial network in medical imaging: a review. Med Image Anal. 2019;58:101552.
Frid-Adar M, Diamant I, Klang E, Amitai M, Goldberger J, Greenspan H. GAN-based synthetic medical image augmentation for increased CNN performance in liver lesion classification. Neurocomputing. 2018;321:321–31.
Onishi Y, Teramoto A, Tsujimoto M, Tsukamoto T, Saito K, Toyama H, Imaizumi K, Fujita H. Automated pulmonary nodule classification in computed tomography images using a deep convolutional neural network trained by generative adversarial networks. Biomed Res Int. 2019;9:6051939.
Onishi Y, Teramoto A, Tsujimoto M, Tsukamoto T, Saito K, Toyama H, Imaizumi K, Fujita H. Multiplanar analysis for pulmonary nodule classification in CT images using deep convolutional neural network and generative adversarial networks. Int J Comput Assist Radiol Surg. 2019. https://doi.org/10.1007/s11548-019-02092-z.
https://ai.googleblog.com/2017/04/federated-learning-collaborative.html. Accessed 28 Dec 2019.
Chang K, Balachandar N, Lam C, Yi D, Brown J, Beers A, Rosen B, Rubin DL, Kalpathy-Cramer J. Distributed deep learning networks among institutions for medical imaging. J Am Med Inform Assoc. 2018;25(8):945–54.
https://www.intel.ai/federated-learning-for-medical-imaging/#gs.9988iz. Accessed 28 Dec 2019.
Sheller MJ, Reina GA, Edwards B, Martin J, Bakas S. Multi-institutional deep learning modeling without sharing patient data: a feasibility study on brain tumor segmentation, Lecture notes in computer science book series (Volume 11383). Brainlesion. 2019;11383:92–104.
Beyer F, Zierott L, Fallenberg EM, Juergens KU, Stoeckel J, Heindel W, Wormanns D. Comparison of sensitivity and reading time for the use of computer-aided detection (CAD) of pulmonary nodules at MDCT as concurrent or second reader. Eur Radiol. 2007;17(11):2941–7.
Samulski M, Hupse R, Boetes C, Mus RDM, den Heeten GJ, Karssemeijer N. Using computer-aided detection in mammography as a decision support. Eur Radiol. 2010;20(10):2323–30.
Rodríguez-Ruiz A, Krupinski E, Mordang J-J, Schilling K, Heywang-Köbrunner SH, Sechopoulos I, Ritse Mann RM. Detection of breast cancer with mammography: effect of an artificial intelligence support system. Radiology. 2019;290(2):305–14.
Kyono T, Gilbert FJ, van der Schaar M. Improving workflow efficiency for mammography using machine learning. J Am Coll Radiol. 2019. https://doi.org/10.1016/j.jacr.2019.05.012.
PSEHB/MDED (Yakuseikisinn). Notification 0523 No. 2, May 23, 2019, Japan. Appendix 4. Guidance for evaluation of artificial intelligence-assisted medical imaging systems for clinical diagnosis. 2019. http://dmd.nihs.go.jp/jisedai/tsuuchi/index.html. Accessed 31 Dec 2019.
US Food and Drug Administration. Proposed regulatory framework for modifications to artificial intelligence/machine learning (AI/ML)-based software as a medical device (SaMD)—discussion paper and request for feedback. 2019. https://www.fda.gov/medical-devices/software-medical-device-samd/artificial-intelligence-and-machine-learning-software-medical-device. Accessed 29 Dec 2019.
Goldenberg R, Peled N. Computer-aided simple triage. Int J Comput Assist Radiol Surg. 2011;6(5):705–11.
Muramatsu C. Overview of subjective similarity of images for content-based medical image retrieval. Radiol Phys Technol. 2018;11(2):109–24.
Owais M, Arsalan M, Choi J, Park KR. Effective diagnosis and treatment through content-based medical image retrieval (CBMIR) by using artificial intelligence. J Clin Med. 2019;8(4):462.
Gillies RJ, Kinahan PE, Hricak H. Radiomics: images are more than pictures, they are data. Radiology. 2016;278(2):563–77.
Bodalal Z, Trebeschi S, Nguyen-Kim TDL, Schats W, Beets-Tan R. Radiogenomics: bridging imaging and genomics. Abdom Radiol. 2019;44(6):1960–84.
Kai C, Uchiyama Y, Shiraishi J, Fujita H, Doi K. Computer-aided diagnosis with radiogenomics: analysis of the relationship between genotype and morphological changes of the brain magnetic resonance images. Radiol Phys Technol. 2018;11(3):265–73.
Yoon H-J, Ramanathan A, Alamudun F, Tourassi G. Deep radiogenomics for predicting clinical phenotypes in invasive breast cancer. In: Proc. SPIE 10718, 14th International Workshop on Breast Imaging (IWBI 2018), 2018. p. 107181H.
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R, Raman R, Nelson PC, Mega JL, Webster DR. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA. 2016;316(22):2402–10.
Poplin R, Varadarajan AV, Blumer K, Liu Y, McConnell MV, Corrado GS, Peng L, Webster DR. Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. Nat Biomed Eng. 2018;2(3):158–64.
Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S. Dermatologist-level classification of skin cancer with deep neural networks. Nature. 2017;542:115–8.
Haenssle HA, Fink C, Schneiderbauer R, Toberer F, Buhl T, Blum A, Kalloo A, Hassen ABH, Thomas L, Enk A, Uhlmann L. Reader study level-I and level-II Groups. Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists. Ann Oncol. 2018;29(8):1836–42.
Bejnordi BE, Veta M, van Diest PJ, et al. Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA. 2017;318(22):2199–210.
Mayo RC, Kent D, Sen LC, Kapoor M, Leung JWT, Watanabe AT. Reduction of false-positive markings on mammograms: a retrospective comparison study using artificial intelligence-base CAD. J Dig Imag. 2019;32(4):618–24.
Aboutalib SS, Mohamed AA, Berg WA, Zuley ML, Sumkin JH, Wu S. Deep learning to distinguish recalled but benign mammography images in breast cancer screening. Clin Cancer Res. 2018;24(23):5902–9.
Wu N, Phang J, Park J, Shen Y, Huang Z, Zorin M, Jastrzebski S, Fevry T, Katsnelson J, Kim E, Wolfson S, Parikh U, Gaddam S, Lin LLY, Ho K, Weinstein JD, Reig B, Gao Y, Pysarenko HTK, Lewin A, Lee J, Airola K, Mema E, Chung S, Hwang E, Samreen N, Kim SG, Heacock L, Moy L, Cho K, Geras KJ. Deep neural networks improve radiologists’ performance in breast cancer screening. IEEE Trans Med Imaging. 2019. https://doi.org/10.1109/TMI.2019.2945514.
Hwang EJ, Park S, Jin KN. Development and validation of a deep learning–based automated detection algorithm for major thoracic diseases on chest radiographs. JAMA Netw Open. 2019;2(3):e191095.
Ardila D, Kiraly AP, Bharadwaj S, Choi B, Reicher JJ, Peng L, Tse D, Etemadi M, Ye W, Corrado G, Naidich DP, Shetty S. End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography. Nat Med. 2019;25:954–61.
Abràmoff MD, Lavin PT, Birch M, Shah NA, Folk JC. Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices. Npj Digit Med. 2018;1:39.
Liu X, Faes L, Kale AU, Wagner SK, Fu DJ, Bruynseels A, Mahendiran T, Moraes G, Shamdas M, Kern C, Ledsam JR, Schmid MK, Balaskas K, Topol EJ, Bachmann LM, Keane PA, Denniston AK. A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis. Lancet Digit Health. 2019;1(6):e271–e297297.
Langlotz C, Allen B, Erickson BJ, Kalpathy-Cramer J, Bigelow K, Cook TS, Flanders AE, Lungren MP, Mendelson DS, Rudie JD, Wang G, Kandarpa K. A roadmap for foundational research on artificial intelligence in medical imaging: from the 2018 NIH/RSNA/ACR/the academy workshop. Radiology. 2019;291(3):781–91.
Choy G, Khalilzadeh O, Michalski M, Do S, Samir AE, Pianykh OS, Geis JR, Pandharipandle PV, Brink JA, Dreyer KJ. Current applications and future impact of machine learning in radiology. Radiology. 2018;288(2):318–28.
https://aimi.stanford.edu/news/rsna-2017-rads-who-use-ai-will-replace-rads-who-don-t. Accessed 28 Dec 2019.
Walter M. Radiologists, AI an accurate combination for detecting breast cancer. AI in Healthcare. 2019. https://www.aiin.healthcare/topics/medical-imaging/radiologists-ai-accurate-breast-cancer-mammography. Accessed 29 Dec 2019.
Funding
This research was supported in part by a Grant-in-Aid for Scientific Research (B) (No. 19H03599) and (C) (No. 19K10347), by the Japan Society for the Promotion of Science, and also in part by a Collaborative Research Grant from EyeTech Co., Ltd., Japan.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The author declares that he has no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Fujita, H. AI-based computer-aided diagnosis (AI-CAD): the latest review to read first. Radiol Phys Technol 13, 6–19 (2020). https://doi.org/10.1007/s12194-019-00552-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12194-019-00552-4