Abstract
A novel, simple, and efficient protocol is described for the synthesis of 1-alkyl-2-(aryloxy)methyl-1H-pyrrolo[2,3-b]quinoxalines via the one-pot reaction of phenol or 2-naphthol derivatives, propargyl bromide, and N-alkyl-3-chloroquinoxaline-2-amines in the presence of palladium catalyst. This one-pot reaction is carried out in the absence of any copper salt at room temperature. The reaction product is dependent on the nature of the base used. The use of morpholine, as the base, affords the final cyclized product, and triethylamine only gives the coupling product.
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26 September 2018
The original version of this article unfortunately contained mistakes. Table 2, entry 6. The structure of the product 4f is missing.
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We gratefully acknowledge the financial support of the Research Council of the Shahrood University of Technology.
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The original version of this article was revised: The structure of the product 4f is shown in Table 2, entry 6.
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Keivanloo, A., Fakharian, M., Nabid, M.R. et al. Novel one-pot synthesis of 1-alkyl-2-(aryloxy)methyl-1H-pyrrolo[2,3-b]quinoxalines via copper-free Sonogashira coupling reaction. J IRAN CHEM SOC 16, 151–160 (2019). https://doi.org/10.1007/s13738-018-1492-y
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DOI: https://doi.org/10.1007/s13738-018-1492-y