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Trabecular Meshwork Regeneration—a Potential Treatment for Glaucoma

  • Regenerative Medicine in Ophthalmology (D. Myung, Section Editor)
  • Published:
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Abstract

Purpose of review

In this review, we overview the pathophysiology of primary open-angle glaucoma as it relates to the trabecular meshwork (TM), exploring modes of TM dysfunction and regeneration via stem cell therapies.

Recent Findings

Stem cells from a variety of sources, including trabecular meshwork, mesenchymal, adipose, and induced pluripotent stem cells, have shown the potential to differentiate into TM cells in vitro or in vivo and to regenerate the TM in vivo, lowering intraocular pressure (IOP) and reducing glaucomatous retinal ganglion cell damage.

Summary

Stem cell therapies for TM regeneration provide a robust and promising suite of treatments for eventual lowering of IOP and prevention of glaucomatous vision loss in humans in the future. Further investigation into stem cell homing mechanisms and the safety of introducing these cells into human anterior chamber, for instance, are required before clinical applications in treating glaucoma patients.

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Funding

This work was supported by NIH grants EY025643 (Y.D.) and P30-EY008098; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness; University of Pittsburgh Summer Premedical Academic Enrichment Program (SPAEP) (A.C.).

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Authors and Affiliations

  1. Department of Ophthalmology, University of Pittsburgh, 910 EEINS, 203 Lothrop St, Pittsburgh, PA, 15213, USA

    Alexander Castro & Yiqin Du

  2. University of Virginia, Charlottesville, VA, 22904, USA

    Alexander Castro

  3. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Yiqin Du

  4. Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Yiqin Du

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  1. Alexander Castro
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  2. Yiqin Du
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Correspondence to Yiqin Du.

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Alexander Castro declares that he has no conflicts of interest. University of Pittsburgh owns a patent “trabecular meshwork stem cells” with Yiqin Du as one of the inventors.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Regenerative Medicine in Ophthalmology

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Castro, A., Du, Y. Trabecular Meshwork Regeneration—a Potential Treatment for Glaucoma. Curr Ophthalmol Rep 7, 80–88 (2019). https://doi.org/10.1007/s40135-019-00203-2

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