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Response to: “Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach”

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References

  1. Johnson TN, Salem F, Jamei M, et al. Prediction of voriconazole non-linear pharmacokinetics using a paediatric physiologically based pharmacokinetic modelling approach. Clin Pharmacokinet. 2015. doi:10.1007/s40262-015-0247-5.

    PubMed  Google Scholar 

  2. Zane NR, Thakker DR. A physiologically based pharmacokinetic model for voriconazole disposition predicts intestinal first-pass metabolism in children. Clin Pharmacokinet. 2014;53(12):1171–82. doi:10.1007/s40262-014-0181-y.

    Article  CAS  PubMed  Google Scholar 

  3. Jiang XL, Zhao P, Barrett JS, Lesko LJ, Schmidt S. Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in children. CPT Pharmacometrics Syst Pharmacol. 2013;2:e80. doi:10.1038/psp.2013.55.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Krekels EH, Johnson TN, den Hoedt SM, Rostami-Hodjegan A, Danhof M, Tibboel D, et al. From pediatric covariate model to semiphysiological function for maturation: part II-sensitivity to physiological and physicochemical properties. CPT Pharmacometrics Syst Pharmacol. 2012;1:e10. doi:10.1038/psp.2012.12.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Salem F, Johnson TN, Barter ZE, Leeder JS, Rostami-Hodjegan A. Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions. J Clin Pharmacol. 2013;53(8):857–65. doi:10.1002/jcph.100.

    Article  PubMed  Google Scholar 

  6. Yanni SB, Annaert PP, Augustijns P, Ibrahim JG, Benjamin DK Jr, Thakker DR. In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3. Drug Metab Dispos. 2010;38(1):25–31. doi:10.1124/dmd.109.029769.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Benowitz NL, Hukkanen J, Jacob P 3rd. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol. 2009;192:29–60. doi:10.1007/978-3-540-69248-5_2.

    Article  CAS  PubMed  Google Scholar 

  8. Cashman JR. Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. Curr Drug Metab. 2000;1(2):181–91.

    Article  CAS  PubMed  Google Scholar 

  9. Cashman JR, Park SB, Berkman CE, Cashman LE. Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Chem Biol Interact. 1995;96(1):33–46.

    Article  CAS  PubMed  Google Scholar 

  10. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, et al. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Drug Metab Dispos. 1993;21(4):587–97.

    CAS  PubMed  Google Scholar 

  11. Chung WG, Park CS, Roh HK, Lee WK, Cha YN. Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. Jpn J Pharmacol. 2000;84(2):213–20.

    Article  CAS  PubMed  Google Scholar 

  12. Hammons GJ, Guengerich FP, Weis CC, Beland FA, Kadlubar FF. Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases. Cancer Res. 1985;45(8):3578–85.

    CAS  PubMed  Google Scholar 

  13. Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther. 2005;106(3):357–87. doi:10.1016/j.pharmthera.2005.01.001.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Lang DH, Yeung CK, Peter RM, Ibarra C, Gasser R, Itagaki K, et al. Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3. Biochem Pharmacol. 1998;56(8):1005–12.

    Article  CAS  PubMed  Google Scholar 

  15. Miki Y, Suzuki T, Tazawa C, Blumberg B, Sasano H. Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol. 2005;231(1–2):75–85. doi:10.1016/j.mce.2004.12.005.

    Article  CAS  PubMed  Google Scholar 

  16. de Wildt SN, Kearns GL, Hop WC, Murry DJ, Abdel-Rahman SM, van den Anker JN. Pharmacokinetics and metabolism of oral midazolam in preterm infants. Br J Clin Pharmacol. 2002;53(4):390–2.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Johnson TN, Tanner MS, Taylor CJ, Tucker GT. Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol. 2001;51(5):451–60.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Fakhoury M, Litalien C, Medard Y, Cave H, Ezzahir N, Peuchmaur M, et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos. 2005;33(11):1603–7. doi:10.1124/dmd.105.005611.

    Article  CAS  PubMed  Google Scholar 

  19. Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, Zeldin DC. The human intestinal cytochrome P450 “pie”. Drug Metab Dispos. 2006;34(5):880–6. doi:10.1124/dmd.105.008672.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL, et al. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J Pharmacol Exp Ther. 1997;283(3):1552–62.

    CAS  PubMed  Google Scholar 

  21. Karlsson MO, Lutsar I, Milligan PA. Population pharmacokinetic analysis of voriconazole plasma concentration data from pediatric studies. Antimicrob Agents Chemother. 2009;53(3):935–44. doi:10.1128/AAC.00751-08.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy at The University of North Carolina at Chapel Hill, 301 Pharmacy Lane, Chapel Hill, NC, 27599, USA

    Nicole R. Zane & Dhiren R. Thakker

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  1. Nicole R. Zane
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  2. Dhiren R. Thakker
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Correspondence to Dhiren R. Thakker.

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Zane, N.R., Thakker, D.R. Response to: “Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach”. Clin Pharmacokinet 54, 569–572 (2015). https://doi.org/10.1007/s40262-015-0254-6

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