Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma (NHL). Usually, it presents as expanding mass in the neck or abdomen but can present in unusual ways as an extranodal disease, with multiorgan involvement. Appropriate suspicion and workup can lead to early diagnosis to initiate early treatment, but it comes with multiple challenges, in case of older frail population. Herewith, we are reporting our patient, a 63-year-old frail older woman presented as multiple cranial nerve palsy and renal impairment at presentation.
Similar content being viewed by others
Availability of Data and Material
Subject to the clearance by the institute ethics and research committee.
Code Availability
Not applicable
References
Diffuse large B-cell lymphoma - Pathology. [cited 2019 Aug 6]. Available from: https://www.pathologyjournal.rcpa.edu.au/article/S0031-3025(17)30471-3/fulltext.
Diffuse large B-cell lymphoma with involvement of the kidney: outcome and risk of central nervous system relapse | Haematologica. [cited 2019 Aug 6]. Available from: http://www.haematologica.org/content/96/7/1002.short#ref-1.
Primary renal lymphoma - OMER - 2007 - Nephrology - Wiley Online Library. [cited 2019 Aug 6]. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1797.2007.00783.x.
Carcinomatous meningitis: leptomeningeal metastases in solid tumors. [cited 2019 Aug 6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656567/.
Imaging of primary and secondary renal lymphoma. Am J Roentgenol. 201(5) (AJR). [cited 2019 Aug 6]. Available from: https://www.ajronline.org/doi/full/10.2214/AJR.13.10669.
Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up† | Annals of Oncology | Oxford Academic. [cited 2019 Aug 6]. Available from: https://academic.oup.com/annonc/article/26/suppl_5/v116/345089#35546363.
Diffuse large B-cell lymphoma: ESMO Clinical Practice Guidelines | ESMO. [cited 2020 Jan 25]. Available from: https://www.esmo.org/Guidelines/Haematological-Malignancies/Diffuse-Large-B-Cell-Lymphoma.
Management of aggressive lymphoma in very elderly patients. [cited 2019 Aug 6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873382/.
Diffuse Large B-cell Lymphoma in the Elderly: A Review of Potential Difficulties | Clinical Cancer Research. [cited 2019 Aug 6]. Available from: https://clincancerres.aacrjournals.org/content/19/7/1660#.
Tailored therapy in an unselected population of 91 elderly patients with DLBCL prospectively evaluated using a simplified CGA. [cited 2019 Aug 6]. Available from: http://theoncologist.alphamedpress.org/content/17/5/663.short.
Author information
Authors and Affiliations
Contributions
Manuscript writing and interpretation of the data: Manicka Saravanan Subramanian and Abhijith Rajaram Rao. Acquisition and interpretation of the data: Urza Bhattarai, Naren Hemachandran, and Mohamad Sulaiman. Critical revision of the manuscript for intellectual content: Aparajit Ballav Dey.
Corresponding author
Ethics declarations
Ethical Approval
All authors declare that this manuscript does not report on a clinical trial and the ethics committee approval is not required.
Consent to Participate
Not applicable
Consent for Publication
I confirm that the authors of the manuscript “Diffuse Large B-cell Lymphoma with Renal Involvement Presenting with Multiple Cranial Nerve Palsy in a Frail Older Adult: a Case Report” made every attempt to obtain written authorization, but the patient was deceased, and the authors were unable to contact any of the patient’s family members. This manuscript contains no patient identifiers and is anonymous. It is compliant with all institutional regulations.
Conflict of Interest
The authors declare no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Medicine
Rights and permissions
About this article
Cite this article
Subramanian, M.S., Rao, A.R., Bhattarai, U. et al. Diffuse Large B-cell Lymphoma with Renal Involvement Presenting with Multiple Cranial Nerve Palsy in a Frail Older Adult: a Case Report. SN Compr. Clin. Med. 3, 1951–1954 (2021). https://doi.org/10.1007/s42399-021-00956-7
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s42399-021-00956-7