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Synthesis, structure, and biologic activity of products of reactions between dinitrodichlorobenzofuroxane and aminopyrimidines in aqueous dimethyl sulfoxide

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Abstract

Reactions of 4,6-dinitro-5,7-dichlorobenzofuroxane with substituted pyrimidines in aqueous DMSO proceed through an intermediate formation of 5-hydroxy-4,6-dinitro-7-chlorobenzofuroxane owing to the hydrolysis of one of the chlorine atoms with the subsequent formation of pyrimidine salts exhibiting a high biologic action.

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Authors and Affiliations

  1. Kazan (Volga region) Federal University, Kremlevskaya ul. 18, Kazan, 420008, Russia

    I. V. Galkina & V. I. Galkin

  2. Kazan National Research Technologic University, Kazan, Russia

    L. M. Yusupova

  3. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia

    A. T. Gubaidullin

Authors
  1. I. V. Galkina
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  2. L. M. Yusupova
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  3. A. T. Gubaidullin
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  4. V. I. Galkin
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Corresponding author

Correspondence to V. I. Galkin.

Additional information

Original Russian Text © I.V. Galkina, L.M. Yusupova, A.T. Gubaidullin, V.I. Galkin, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 5, pp. 744–749.

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Galkina, I.V., Yusupova, L.M., Gubaidullin, A.T. et al. Synthesis, structure, and biologic activity of products of reactions between dinitrodichlorobenzofuroxane and aminopyrimidines in aqueous dimethyl sulfoxide. Russ J Org Chem 52, 734–739 (2016). https://doi.org/10.1134/S1070428016050201

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  • DOI: https://doi.org/10.1134/S1070428016050201

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