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The analog of arginine-vasopressin (6-9) fragment, Ac-D-SPRG, exhibits antidepressant action in rats in case of intranasal injection

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Abstract

The antidepressant properties of newly synthesized analog of arginine-vasopressin fragment analog, Ac-D-SPRG, were tested using Porsolt’s swimming test on white rats. It was demonstrated that this substance when injected intranasally decreases the depression in comparison with the control group.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Leninskie gory, 1, str. 12, Moscow, 119234, Russia

    A. S. Belyakova, O. G. Voskresenskaya & A. A. Kamensky

  2. Department of Genetics, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

    A. A. Sinjushin

  3. Institute of Bioorganic Chemistry, National Academy of Sciences, Minsk, Republic of Belarus

    V. P. Golubovich

Authors
  1. A. S. Belyakova
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  2. A. A. Sinjushin
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  3. O. G. Voskresenskaya
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  4. A. A. Kamensky
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  5. V. P. Golubovich
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Correspondence to A. S. Belyakova.

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Belyakova, A.S., Sinjushin, A.A., Voskresenskaya, O.G. et al. The analog of arginine-vasopressin (6-9) fragment, Ac-D-SPRG, exhibits antidepressant action in rats in case of intranasal injection. Neurochem. J. 9, 201–205 (2015). https://doi.org/10.1134/S1819712415030034

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  • DOI: https://doi.org/10.1134/S1819712415030034

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