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Aging and Drug Therapy

  • Book
  • © 1984

Overview

Editors:
  1. G. Barbagallo-Sangiorgi

    1. Institute of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. A. N. Exton-Smith

    1. School of Medicine, University College London, London, England

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Physics of Solids and Liquids (PSLI)

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Table of contents (40 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Pharmacokinetics in Advancing Age

    • I. H. Stevenson
    Pages 1-8

  3. Brain Receptors and Aging in Relation to Drug Effect

    • S. Garattini, A. de Blasi
    Pages 9-22

  4. Clinical Trials in Old Subjects

    • S. M. Chierichetti
    Pages 23-30

  5. General Symptomatology of Pathogenic Drug Usage in Old Patients

    • G. Barbagallo Sangiorgi
    Pages 31-40

  6. Epidemiological Consideration of Adverse Reactions to Drugs

    • J. Williamson
    Pages 41-49

  7. Drug Compliance

    • M. J. Denham
    Pages 51-62

  8. The Treatment of Sleep Disorders

    • Peter J. Cook
    Pages 63-82

  9. Assessment and Management of Confused Old People in General Hospitals

    • R. Jones
    Pages 83-94

  10. Treatment of Depression in the Elderly

    • R. M. Fraser
    Pages 95-103

  11. Treatment of Chronic Brain Failure

    • A. Agnoli, N. Martucci, V. Manna
    Pages 105-120

  12. Perspective in the Treatment of Dementia

    • L. Bracco, D. Insitari, L. Amaducci
    Pages 121-127

  13. Physiopathology and Treatment of Transient Ischaemic Attacks

    • C. Loeb
    Pages 129-138

  14. Psychodynamic Treatment of the Elderly

    • I. Simeone
    Pages 139-148

  15. Nutrition of Elderly Patients in Long Care Wards

    • Peter H. Millard, Eleanor Peel, Sue Thomas
    Pages 149-153

  16. Disorders of Fluid and Electrolyte Metabolism in the Elderly

    • A. Borghetti
    Pages 155-174

  17. Long Term Treatment with Oral Antidiabetics

    • F. S. Feruglio
    Pages 175-187

  18. Insufficiency of Haemoactive Principles in the Elderly and its Treatment

    • A. Ventura, U. Senin, E. Mannarino
    Pages 189-193

  19. Plasma Lipids and Frequency of Hyperlipidaemia in the Elderly: Indications and Cost/Benefit Ratio of Hypolipidaemic Treatment

    • R. Fellin, G. Valerio, T. Beroldin, A. L. Angelini, O. De Candia, G. Crepaldi
    Pages 195-220

  20. Metabolic Bone Disease and Fracture of the Femoral Neck

    • A. N. Exton-Smith
    Pages 221-230
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Keywords

About this book

One of the greatest advances in Geriatric Medicine during the last quarter of a century has been the increased realization of the possibilities of treatment for elderly patients. Neglect has been replaced by a more optimistic therapeutic endeavour and countless old people have benefitted from this approach. But there is also a drawback, and this is the risk of hazardous side effects of medication which are often directly proportional to the biological potency of the drug and may be unpredictably increased due to changes in the senile organism. In fact the anatomical and biological changes in old age alter both the kinetics of most drugs and the receptor response. On account of these changes the individual tolerance of aged patients to drug therapy may be quite different from that of younger subjects. Thus for a variety of reasons elderly patients receive more drugs, but they are at a higher risk of encountering adverse reactions, which often show atypical clinical features. We can therefore speak of "geriatric iatrogenic disorders" and point out that some of these side effects are determined by a complex pathogenesis due to the particular pathophysiological condition in the elderly. It is important to encourage the habit of individ­ ually evaluating potential risk versus expected advantages of drugs in keeping with the same principles adopted in the evaluation of cost/benefit ratio.

Editors and Affiliations

  • Institute of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy

    G. Barbagallo-Sangiorgi

  • School of Medicine, University College London, London, England

    A. N. Exton-Smith

Bibliographic Information

  • Book Title: Aging and Drug Therapy

  • Editors: G. Barbagallo-Sangiorgi, A. N. Exton-Smith

  • Series Title: Physics of Solids and Liquids

  • DOI: https://doi.org/10.1007/978-1-4613-2791-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1984

  • Hardcover ISBN: 978-0-306-41739-9Due: 01 September 1984

  • Softcover ISBN: 978-1-4612-9721-5Published: 04 November 2011

  • eBook ISBN: 978-1-4613-2791-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 523

  • Topics: Physics, general

  • Industry Sectors: Energy, Utilities & Environment, Engineering

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