Overview
- Provides state-of-the-art review on ABC transporter research
- Describes the myriad roles of allocrites like ion, nutrients, peptides, etc.
- Explores future prospects of ABC transporter research
- Includes supplementary material: sn.pub/extras
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Table of contents (15 chapters)
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Front Matter
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ABC Transporters: A Structure-Function Perspective
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Front Matter
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Human ABC Transporters of Medical Relevance
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Front Matter
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Keywords
About this book
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: ABC Transporters - 40 Years on
Editors: Anthony M. George
DOI: https://doi.org/10.1007/978-3-319-23476-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-23475-5Published: 23 December 2015
Softcover ISBN: 978-3-319-79489-1Published: 27 March 2019
eBook ISBN: 978-3-319-23476-2Published: 16 December 2015
Edition Number: 1
Number of Pages: XIV, 376
Number of Illustrations: 44 b/w illustrations, 6 illustrations in colour
Topics: Membrane Biology, Biological and Medical Physics, Biophysics, Biochemistry, general, Drug Resistance