Overview
- Study on the Biological Function of Survivin
- Includes supplementary material: sn.pub/extras
Part of the book series: BestMasters (BEST)
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Table of contents (5 chapters)
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Front Matter
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Back Matter
Keywords
About this book
In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Impact of Survivin Acetylation on its Biological Function
Authors: David Dannheisig
Series Title: BestMasters
DOI: https://doi.org/10.1007/978-3-658-18623-4
Publisher: Springer Spektrum Wiesbaden
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature 2017
Softcover ISBN: 978-3-658-18622-7Published: 16 June 2017
eBook ISBN: 978-3-658-18623-4Published: 06 June 2017
Series ISSN: 2625-3577
Series E-ISSN: 2625-3615
Edition Number: 1
Number of Pages: XXIII, 104
Number of Illustrations: 31 b/w illustrations, 10 illustrations in colour
Topics: Cancer Research, Biomedical Engineering/Biotechnology, Cell Biology
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma