Overview
- Editors:
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Evgeny N. Vulfson
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Institute of Food Research, Norwich, UK
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Peter J. Halling
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University of Strathclyde, Glasgow, UK
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Herbert L. Holland
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Brock University, St. Catharines, Ontario, Canada
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Table of contents (49 protocols)
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Control of Enzyme Activity in Nonaqueous Solvents
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- Johann Partridge, Neil Harper, Barry D. Moore, Peter J. Halling
Pages 227-234
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- Marie-Pierre Bousquet, René-Marc Willemot, Pierre Monsan, Emmanuel Boures
Pages 235-239
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Synthetic Applications
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Front Matter
Pages 241-242
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- Alexandra N. E. Weissfloch, Romas J. Kazlauskas
Pages 243-259
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- Didier Rotticci, Jenny Ottosson, Torbjörn Norin, Karl Hult
Pages 261-276
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- Patrizia Ferraboschi, Enzo Santaniello
Pages 291-305
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- Per Berglund, Erik Hedenström
Pages 307-317
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- Gianluca Ottlina, Francesco Secundo, Giorgio Colombo, Giacomo Carrea
Pages 319-324
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- Thierry Maugard, Magali Remaud-Simeon, Pierre Monsan
Pages 325-330
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- Haralambos Stamatis, Aristotelis Xenakis, Fragiskos N. Kolisis
Pages 331-338
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- Takuo Kawamoto, Atsuo Tanaka
Pages 339-355
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- Valérie Rolland, René Lazaro
Pages 357-371
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- Shui-Tein Chen, Boonyaras Sookkheo, Suree Phutrahul, Kung-Tsung Wang
Pages 373-400
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- Shinobu Oda, Takeshi Sugai, Hiromichi Ohta
Pages 401-416
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- Andrew J. Smallridge, Maurie A. Trewhella
Pages 417-422
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- Brian Morgan, David R. Dodds, Michael J. Homann, Aleksey Zaks, Robert Vail
Pages 423-467
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Reaction Systems and Bioreactor Design
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Front Matter
Pages 469-470
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- Markus Erbeldinger, Uwe Eichhorn, Peter Kuhl, Peter J. Halling
Pages 471-477
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- Cristina Otero, Jose A. Arcos, Hugo S. Garcia, Charles G. Hill Jr.
Pages 479-496
About this book
Enzymatic catalysis has gained considerable attention in recent years as an efficient tool in the preparation of natural products, pharmaceuticals, fine chemicals, and food ingredients. The high selectivity and mild reaction con- tions associated with enzymatic transformations have made this approach an attractive alternative in the synthesis of complex bioactive compounds, which are often difficult to obtain by standard chemical routes. However, the maj- ity of organic compounds are not very soluble in water, which was traditi- ally perceived as the only suitable reaction medium for the application of biocatalysts. The realization that most enzymes can function perfectly well under nearly anhydrous conditions and, in addition, display a number of useful properties, e. g. , highly enhanced stability and different selectivity, has d- matically widened the scope of their application to the organic synthesis. Another great attraction of using organic solvents rather than water as a reaction solvent is the ability to perform synthetic transformations with re- tively inexpensive hydrolytic enzymes. It is worth reminding the reader that in vivo, the synthetic and hydrolytic pathways are catalyzed by different enzymes. However, elimination of water from the reaction mixture enables the “reversal” of hydrolytic enzymes and thus avoids the use of the expensive cofactors or activated substrates that are required for their synthetic count- parts.
Reviews
"The handbook provides detailed descriptions of a variety of methods used for performing enzymatic reactions in nonaqueous media." - Journal of the American Chemical Society
"...includes detailed descriptions of the latest technologies used for biocatalysis in nearly anhydrous systems. Numerous specific enzymatic reactions, bioreactors, and useful techniques are carefully explained in a format intelligible to most readers in spite of the great diversity of the fields covered. This work of reference will be extremely valuable to those interested in enzymatic and asymmetric synthesis." - Natural Products Reports
Editors and Affiliations
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Institute of Food Research, Norwich, UK
Evgeny N. Vulfson
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University of Strathclyde, Glasgow, UK
Peter J. Halling
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Brock University, St. Catharines, Ontario, Canada
Herbert L. Holland