Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Austin, M.A. 1991. Atheroscler. Thromb. 11, 2–14. Plasma triglyceride and coronary heart disease.
Hodis, H.N., Mack, W.J., Azen, S.P., Alaupovic, P., Pogoda, J.M., LaBree, L, Hemphill, L.C., Kramsch, D.M. & Blankenhorn, D.H. 1994. Circulation, 90, 42–49. Triglyceride-and cholesterol-rich lipoproteins have a different effect on mild/moderate and sereve lesion progression as assayed by quantitative coronary angiography in a controlled trial of lovastatin.
Bang, H.O., Dyerberg, J. & Nielsen, A.B. 1971. Lancet, 710, 1143–1145. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos.
Nestel, P.J., Connor, W.E., Reardon, M.F., Connor, S.W.S. & Boston, R. 1984. J. Clin. Invest., 74, 82–89. Suppression by diets rich in fish oil of very low density lipoprotein production in man.
Shepherd, J. 1994. Atherosclerosis, 110, S55–S63. The flbrates in clinical practice: focus on micronised fenofibrate.
Staels, B., Vu-Dac, N., Kosykh, V.A., Saladin, R., Fruchart, J.-C, Dallongeville, J. & Auwerx, J. 1995. J. Clin. Invest, 95, 705–712. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomeal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
Hertz, R., Bishara-Shieban, J. & Bar-Tana, J. 1995. J. Biol. Chem., 270, 13470–13475. Mode of action of peroxisome proliferators as hypolipidemic drugs.
Leaf, A. & Kang, J. 1996. J. Intern. Med., 240, 5–12. Prevention of cardiac sudden death by N-3 fatty acids: a review of the evidence.
Harris, W. 1997. Am. J. Clin. Nutr., 65, 1645S–1654S. n-3 fatty acids and serum lipoproteins: human studies.
Blok, W., Katan, M. & van der Meer, J. W. 1996. J. Nutr., 126, 1515–1533. Modulation of inflammation and cytokine production by dietary (n-3) fatty acids.
Grønn, M., Christensen, E., Hagve, T.A. & Christophersen, B. O. 1992. Biochim. Biophys. Acta, 1125, 35–43. Effects of dietary purified eicosapentaenoic acid (20:5(n-3)) and docosahexaenoicacid (22:6(n-3)) on fatty acid desaturation and oxidation in isolated rat liver cell.
Frøyland, L., Vaagenes, H., Asiedu, D., Garras, A., Lie, ø. & Berge, R.K. 1996. Lipids, 31, 169–178. Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs.
Von Schacky, C. & Weber, P.C. 1985. J. Clin. Invest., 76, 2446–2450. Metabolism and effects of platlet function of the purified eicosapentaenoic and docosahexaenoic acid in humans.
Berge, R.K. 1993. Omega-3 News, 1, 5–7. The triglyceride-lowering effect of omega-3 fatty acids. Is it all in eicosapentaenoic acid.
Soutar, A. 1978. Nature, 273, 11–12. Does dietary fat influence plasma lipiorotein structure?
Asiedu, D.K., Skorve, J., Willumsen, N., Demoz, A. & Berge, R.K. 1993. Biochim. Biophys. Acta, 1166, 73–76. Early effects on mitochondrial and peroxisomal β-oxidation by the hypolipidemic 3-thia fatty acids in rat livers.
Asiedu, D.K., Demoz, A., Skorve, J., Grav, H.J. & Berge, R.K. 1994. Biochem. Pharmacol., 49, 1013–1022. Acute modulation of rat hepatic lipid metabolism by sulphur-substituted fatty acid analogues.
Skorve, J., Rustan, A.C. & Berge, R.K. 1995. Lipids, 30, 987–994. Effects of non-β-oxidablesulfur-substituted fatty acid analogues on synthesis and secreation of triacylglycerol and cholesterol in cultured rat hepatocytes.
Frøyland, L., Madsen, L., Sjursen, W, Garras, A., Lie, ø., Songstad, J., Rustan, A.C. & Berge, R.K. 1997. J. Lipid Res., 38, 1522–1534. Effect of 3-thia fatty acids on the lipid composition of rat liver, lipoproteins, and heart.
Madsen, L., Frøyland, L., Dyrøy, E., Helland, K. & Berge, R.K. 1998. J. Lipid Res., 39, 583–593. Docosahexaenoic-and eicosapentaenoic acid are differently metabolized in rat liver during mitochondria-and peroxisome proliferation.
Lazo, O., Contreras, M., Yoshida, Y., Singh, A.K., Stanley, W., Weise, M. & Singh, I. 1990. J. Lipid Res., 31, 583–595. Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases.
Willumsen, N., Vaagenes, H., Asiedu, D., Lie, ø., Rustan, A.C. & Berge, R.K. 1996. Lipids, 31, 579–592. Eicosapentaenoic acid but not docosahexaenoic acid (both as ethyl esters) increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression. A potential mechanism for the hypolipidemic action of fish oil in rats.
Willumsen, N., Hexeberg, S., Skorve, J., Lundquist, M. & Berge, R.K. 1993. J. Lipid Res., 34, 13–22. Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats.
Frøyland, L., Madsen, L., Vaagenes, H., Totland, G.K., Auwerx, J., Kryvi, H., Staels, B. & Berge, R.K. 1997. J. Lipid Res., 38, 1851–1858. Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism.
Mannaerts, G.P., Debeer, L.J., Thomas, J. & DeShepper, P.J. 1979. J. Biol. Chem., 254, 4585–4595. Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate treated rats.
Asiedu, D.K., Demoz, A., Skorve, J., Grav, H.J. & Berge, R.K. 1995. Biochem. Pharmacol., 49, 4013–1022. Acute modulation of rat hepatic lipid metabolism by sulphur-substituted fatty acid analogues.
Asiedu, D.K., Al-Shurbaji, A., Rustan, A.C., Björkhem, I., Berglund, L. & Berge, R.K. 1995. Em J. Biochem., 227, 715–722. Hepatic fatty acid metabolism as a determinant of plasmaand liver triacylglycerol levels.
Willumsen, N., Skorve, J., Hexeberg, S., Rustan, A.C. & Berge, R.K. 1993. Lipids, 28, 683–689. The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis.
Foreman, B.M., Chen, J. & Evans, R.M. 1996. Ann. N. Y. Acad. Sci, 804, 266–275. The peroxisome proliferatoe activated receptors: ligands and activators.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Madsen, L., Dyrøy, E., Berge, R. (2002). EPA and DHA Possess Different Metabolic Properties. In: Quant, P.A., Eaton, S. (eds) Current Views of Fatty Acid Oxidation and Ketogenesis. Advances in Experimental Medicine and Biology, vol 466. Springer, Boston, MA. https://doi.org/10.1007/0-306-46818-2_36
Download citation
DOI: https://doi.org/10.1007/0-306-46818-2_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-46200-9
Online ISBN: 978-0-306-46818-6
eBook Packages: Springer Book Archive