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Trypanosome Factors Controlling Population Size and Differentiation Status

  • Chapter
The African Trypanosomes

Part of the book series: World Class Parasites ((WCPA,volume 1))

Abstract

African trypanosomes undergo a complex life cycle involving an insect vector and vertebrate host. Growth, differentiation and population size in both the vector and host species are carefully controlled, ensuring survival and transmission of the parasite. Population control in vector and mammal hosts is associated with parasite transition from replicating to non-replicating forms, the latter of which is specialized for infection. Recently it was shown that bloodstream form trypanosomes release a low molecular weight factor that feeds back on the parasites causing them to cease division. We have found that the factor acts between the different African trypanosome species, consistent with a common mechanism of growth control. The factor also acts on tsetse-transmitted metacyclic form trypanosomes blocking their infectivity for mammals. Our data suggests that the factor is internalized via a trypanosome cell surface receptor, binds to adenosine ribosylation factor 1 and suppresses endocytosis.

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  1. International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya

    N.B. Murphy

  2. ID-Lelystad, Insitute for Animal Science and Health, Edelhertweg 15, 8219 PH, Lelystad, The Netherlands

    T. Olijhoek

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Murphy, N., Olijhoek, T. (2002). Trypanosome Factors Controlling Population Size and Differentiation Status. In: The African Trypanosomes. World Class Parasites, vol 1. Springer, Boston, MA. https://doi.org/10.1007/0-306-46894-8_9

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  • DOI: https://doi.org/10.1007/0-306-46894-8_9

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