Skip to main content
SpringerLink
Log in

Dipeptidylpeptidase IV Activities in Prostatic Secretions

  • Chapter
Dipeptidyl Aminopeptidases in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 524))

  • 363 Accesses

Conclusions

Evaluation of DPP IV activities in expressed prostatic secretions indicates that the peripheral zone of the human prostate is a predominant source of DPP IV in prostatic secretions. Although, DPP IV activities are higher in prostate cancer tissues, there was not a statistically significant association of DPP IV activities in prostatic secretions and cancer as determined by biopsy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Yaron, A. and Naider, F., 1993, Proline-dependent structural and biological properties of peptides and proteins. Crit. Rev. Biochem. Molec. Biol. 28:31–81.

    Article  CAS  Google Scholar 

  2. De Meester, I., Durinx, C., Bal, G., Proost, P., Struyf, S., Goossen, F., Augustyns, K., and Scharpe, S., 2000, Natural substrates of dipeptidylpeptidase IV. Adv. Exp. Biol. Med. 477:67–87.

    Google Scholar 

  3. Morimoto, C., Torimoto, Y., Levinson, G., Rudd, C.E., Schreiber, M., Dang, N.H., Letvin, N., and Schlossman, S.F., 1989, IF7, a novel cell surface molecule involved in helper function of CD4 cells. J. Immunol. 143:3420–3439.

    Google Scholar 

  4. Hegen, M., Niedobitek, G., Klein, C.E., Stein, H., and Fleischer, B., 1990, The T cell triggering molecule Tp103 is associated with dipeptidyl aminopetidase IV activity. J. Immunol. 144:2908–2914.

    PubMed  CAS  Google Scholar 

  5. Schön, E., Ansorge, S., 1990, Dipeptidyl peptidase IV in the immune system. Cytofluorometric evidence for induction of the enzyme on activated T lymphocytes. Biol Chem Hoppe Seyler 371(8):699–705.

    PubMed  Google Scholar 

  6. Hanski, C., Huhle, T., and Reutter, W., 1985, Involvement of plasma membrane dipeptidyl peptidase IV in fibronectin mediated adhesion of cells in collagen. Biol. Chem. Hoppe-Seyler 366:1169–1176.

    PubMed  CAS  Google Scholar 

  7. Löster, K., Zeilinger, K., Schuppan, D., and Reutter, W., 1995, The cysteine-rich region of dipeptidyl peptidase IV (CD26) is the collagen-binding site. Biochem. Biophys. Res. Commun. 217:341–348.

    PubMed  Google Scholar 

  8. Kullertz, K., Nagy, M., Fishcer, G., and Barth, A., 1986, Isolierung und Characterisierung der Dipeptidylpeptidase IV aus humanem Seminalplasma. Biomed. Biochim. Med. 45:291–303.

    CAS  Google Scholar 

  9. Vanhoof, G., De Meester, I., van Sande, M., Scharpe, S., Yaron, A., 1992, Distribution of proline-specific aminopeptidases in human tissues and body fluids. Eur J Clin Chem Clin Biochem. 30(6):333–8.

    PubMed  CAS  Google Scholar 

  10. Wilson, M.J., Ruhland, A.R., Pryor, J.L., Ercole, C.E., Sinha, A.A., Hensleigh, H., Kaye, K.W., Dawkins, H.J.S., Wasserman, N.F., Reddy, P., and Ahmed, K., 1998, Prostate specific origin of dipeptidylpeptidase IV (CD26) in human seminal plasma. J. Urol. 160:1905–1909.

    PubMed  CAS  Google Scholar 

  11. Dinjens, W.N.M, Kate, J.T., Kirch, J.A.J.M., Tanke, H.J., Van Der Linden, E.P.M., Van Den Inhg, H.F.G.M., Van Steenbrugge, G.J., Khan, P.M., and Bosman, F.T., 1990, Adenosine deaminase complexing protein (ADCP) expression and metastatic potential in prostatic adenocarcinomas. J. Pathol. 160:195–201.

    Article  PubMed  CAS  Google Scholar 

  12. Bodenrieder, T., Finstad, C.L., Freeman, R.H., Papandreou, C.N., Scher, H.I., Albino, A.P., Reuter, V.E., and Nanus, D.M., 1997, Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malilgnant human prostate tissue. Prostate 33:225–232.

    Google Scholar 

  13. Wilson, M.J., Ruhland, A.R., Quast, B.J., Reddy, P.K., Ewing, S.L., and Sinha, A.A., 2000, Dipeptidylpeptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands. J. Androl. 21:220–226

    PubMed  CAS  Google Scholar 

  14. Lepor, H., Wang, B., and Shapiro, E., 1994, Relationships between prostatic epithelial volume and serum prostatic-specific antigen levels. Urology 44:199–205.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. VA Medical Centea and Departments of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

    Michael J. Wilson

  2. Urologic Surgery, University of Minnesota, Minneapolis, MN, USA

    Michael J. Wilson & Joel W. Slaton

  3. University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN, USA

    Michael J. Wilson, Joel W. Slaton, Neil F. Wasserman & Akhouri A. Sinha

  4. Radiology, University of Minnesota, Minneapolis, MN, USA

    Neil F. Wasserman

  5. Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN, USA

    Akhouri A. Sinha

Authors
  1. Michael J. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ross Haller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joel W. Slaton
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Neil F. Wasserman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Akhouri A. Sinha
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Milan, Italy

    Rodolfo Paoletti

  2. State University of New York at Buffalo, USA

    Nathan Back

  3. The Weizmann Institute of Science, Israel

    Irun R. Cohen

  4. Wistar Institute, USA

    David Kritchevsky

  5. N.S. Kline Institute for Psychiatric Research, USA

    Abel Lajtha

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

Wilson, M.J., Haller, R., Slaton, J.W., Wasserman, N.F., Sinha, A.A. (2004). Dipeptidylpeptidase IV Activities in Prostatic Secretions. In: Back, N., Cohen, I.R., Kritchevsky, D., Lajtha, A., Paoletti, R. (eds) Dipeptidyl Aminopeptidases in Health and Disease. Advances in Experimental Medicine and Biology, vol 524. Springer, Boston, MA. https://doi.org/10.1007/0-306-47920-6_32

Download citation

  • DOI: https://doi.org/10.1007/0-306-47920-6_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47717-1

  • Online ISBN: 978-0-306-47920-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation