6. Concluding Remarks
Calcium release from the SR in skeletal muscle is brought about by opening of RyR/calcium release channels. RyR can be activated by Ca2+ (CICR), but physiological opening of RyR is not mediated by Ca2+. RyR is considered to open physiologically as a result of interaction with voltage sensor protein in the T-tubule membrane, and its opening mode is quite different from that of CICR. The physiological mode of opening is mimicked by clofibric acid and possibly by cerivastatin in the absence of Ca2+. On the other hand, CICR mode of opening of RyR in skeletal muscle plays the major role in MH or during caffeine action. The exact operation of RyRs in physiological calcium release remains to be solved.
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Endo, M. (2005). Mechanisms of Calcium Release from the Sarcoplasmic Reticulum in Skeletal Muscle. In: Sugi, H. (eds) Sliding Filament Mechanism in Muscle Contraction. Advances in Experimental Medicine and Biology, vol 565. Springer, Boston, MA. https://doi.org/10.1007/0-387-24990-7_18
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