Abstract
Recent advances in nuclear-medicine based small-animal imaging technology have enabled researchers to acquire in vivo images of the biodistribution of radiolabeled molecules in small-animal models such as mice. The standard imaging method requires the use of anesthetic and/or physical restraint to immobilize the mouse during image acquisition of the radioisotope tracer biodistribution. This has the potential to interfere with neurological or other processes that are being studied.With this in mind, Oak Ridge National Laboratory (ORNL)and Thomas Jefferson National Accelerator Facility (Jefferson Lab), in collaboration with Royal Prince Alfred Hospital (RPAH)in Sydney, Australia and Johns Hopkins University, designed and constructed a high-resolution single-photon emission tomography (SPECT)system to study unrestrained,unanesthetized mice. Others have reported development of scintillator based PET isotope probes and systems to study the brain of unanesthetized rodents +Woody, 2001, Zimmer, 2002, Vaska, 2001-.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. S. Goddard, S. S. Gleason, M. J. Paulus, A. Weisenberger, M. Smith, B. Welch, and R. Wojcik, “Real-time landmark-based unrestrained animal tracking systemfor motion-corrected PET/SPECT imaging,” 2002 IEEE Medical Imaging Conference Record, October 2002.
S.R. Meikle, P. Kench, R. Wojcik, M. F. Smith, A.G. Weisenberger, S. Majewski, M. L. F. Lerch, and A. B. Rozenfeld, “Performance evaluation of a multipinhole small animal SPECT system,” 2003 IEEE Medical Imaging Conference Record, October 2003.
M. F. Smith, S. R. Meikle, S. Majewski, A. G. Weisenberger, “Design of multipinhole collimators for small animal SPECT,” 2003 IEEE Medical Imaging Conference Record, October 2003.
P. Vaska, D. J. Schlyer, C. L. Woody, S. P. Stoll, V. Radeka, and N. Volkow, “Imaging the unanesthetized rat brain with PET: a feasibility study,” 2001 IEEE Medical Imaging Conference Record, October 2001.
http://www.ivp.se/documentation/technology/LaserTriangulation.pdf
A. G. Weisenberger, B. Kross, S. S. Gleason, J. Goddard, S. Majewski, S. R. Meikle, M. J. Paulus, M. Pomper, V. Popov, M. F. Smith, B. L. Welch and R. Wojcik, “Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking,” 2003 IEEE Medical Imaging Conference Record, October 2003.
B. L. Welch, S. Majewski, V. Popov, A.G. Weisenberger, R. Wojcik, J. S. Goddard, S. S. Gleason and M. J. Paulus, “Acquisition and control for a combined SPECT/infrared tracking system for restraint-free small animal imaging,” 2003 IEEE Medical Imaging Conference Record, October 2003.
C. L. Woody, S. P. Stoll, D. J. Schlyer, M. Gerasimov, P. Vaska, S. Shokouhi, N. Volkow, J. S. Fowler, and S. L. Dewey, “A study of scintillation beta microprobes,” 2001 IEEE Medical Imaging Conference Record, October 2001.
L. Zimmer, W. Hassoun, F. Pain, F. Bonnefoi, P. Laniece, R. Mastrippolito, L. Pinot, J. F. Pujol, and V. Leviel, “SIC, an intracerebral beta(+)-range-sensitive probe for radiopharmacology investigations in small laboratory animals: binding studies with (11)C-raclopride,” Journal of Nuclear Medicine, vol. 43(2), pp. 227–233, 2002.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this chapter
Cite this chapter
Weisenberger, A.G. et al. (2005). A Small-Animal SPECT Imaging System Utilizing Position Tracking of Unanesthetized Mice. In: Kupinski, M.A., Barrett, H.H. (eds) Small-Animal Spect Imaging. Springer, Boston, MA. https://doi.org/10.1007/0-387-25294-0_18
Download citation
DOI: https://doi.org/10.1007/0-387-25294-0_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25143-1
Online ISBN: 978-0-387-25294-0
eBook Packages: EngineeringEngineering (R0)