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References
Eto T. (2001) A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides. Peptides 22:1693–1711.
Feinstein R, Kanety H, Papa MZ, Lunenfeld B, and Karasik A. (1993) Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem 268:26055–26058.
Fukai N, Yoshimoto T, Sugiyama T, Ozawa N, Sato R, Shichiri M, Hirata Y. (2004) Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues. Am J Physiol Endocrinol Metab (in press)
Green H and Kehinde O. (1975) An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5:19–27.
Green H and Kehinde O. (1976) Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 7:105–113.
Hayashi M, Shimosawa T, Isaka M, Yamada S, Fujita R, and Fujita T. (1997) Plasma adrenomedullin in diabetes. Lancet 350:1449–1450.
Hotamisligil GS, Shargill NS, and Spiegelman BM. (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87–91.
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, and Spiegelman BM. (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 271:665–8.
Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, and Eto T. (1993a) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553–560.
Li Y, Totsune K, Takeda K, Furuyama K, Shibahara S, and Takahashi K. (2003a) Decreased expression of adrenomedullin during adipocyte-differentiation of 3T3-L1 cells. Hypertens Res 26(Suppl):S41–S44.
Li Y, Totsune K, Takeda K, Furuyama K, Shibahara S, and Takahashi K. (2003b) Differential expression of adrenomedullin and resistin in 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Eur J Endocrinol 149:231–238.
Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, and Matsubara K. (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221:286–289.
Martinez A, Weaver C, Lopez J, Bhathena SJ, Elsasser TH, Miller MJ, Moody TW, Unsworth EJ, and Cuttitta E. (1996) Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Endocrinology 137:2626–2632.
McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, and Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393:333–339.
Nagae T, Mukoyama M, Sugawara A, Mori K, Yahata K, Kasahara M, Suganami T, Makino H, Fujinaga Y, Yoshioka T, Tanaka I, and Nakao K. (2000) Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Biochem Biophys Res Commun 270:89–93.
Nambu T, Arai H, Moriyama K, Komatsu Y, and Nakao K. (2003) Adrenomedullin gene expression in adipose tissues. Program and Abstracts. The 7th Scientific Session of the Japanese Society of Cardiovascular Endocrinology and Metabolism. p 94. (Abstract in Japanese)
Shimosawa T, Ogihara T, Matsui H, Asano T, Ando K, and Fujita T. (2003) Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress. Hypertension 41:1080–1085.
Stephens JM and Pekala PH. (1991) Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem 266:21839–21845.
Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, and Lazar MA. (2001) The hormone resistin links obesity to diabetes. Nature 409:307–312.
Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, and Matsuo H. (1994) Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha. Biochem Biophys Res Commun. 203:719–26.
Takahashi K. (2003) The brainstem is a key target for neuroendocrine research on obesity. Endocrinology 144:4690–4691. (Editorial)
Takahashi K. (2001) Adrenomedullin from a pheochromocytoma to the eye: implications of the adrenomedullin research for endocrinology in the 21st century. Tohoku J Exp Med 193:79–114.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, and Friedman JM. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432.
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Takahashi, K. (2005). Adrenomedullin as an Adipokine. In: Nishikimi, T. (eds) Adrenomedullin in Cardiovascular Disease. Basic Science for the Cardiologist, vol 19. Springer, Boston, MA. https://doi.org/10.1007/0-387-25405-6_8
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DOI: https://doi.org/10.1007/0-387-25405-6_8
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