Skip to main content

Gelatinase B Participates in Collagen II Degradation and Releases Glycosylated Remnant Epitopes in Rheumatoid Arthritis

  • Conference paper
Glycobiology and Medicine

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahrens, D., Koch, A.E., Pope, R.M., Stein-Picarella, M., and Niedbala, M.J. (1996). Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. Arthritis Rheum. 39, 1576–1587.

    Article  CAS  PubMed  Google Scholar 

  • Akahoshi, T., Endo, H., Kondo, H., Kashiwazaki, S., Kasahara, T., Mukaida, N., Harada, A., and Matsushima, K. (1994). Essential involvement of interleukin-8 in neutrophil recruitment in rabbits with acute experimental arthritis induced by lipopolysaccharide and interleukin-1. Lymphokine Cytokine. Res. 13, 113–116.

    CAS  PubMed  Google Scholar 

  • Andersson, E.C., Hansen, B.E., Jacobsen, H., Madsen, L.S., Andersen, C.B., Engberg, J., Rothbard, J.B., McDevitt, G.S., Malmstrom, V., Holmdahl, R., Svejgaard, A., and Fugger, L. (1998). Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 95, 7574–7579.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arndt, S.O., Vogt, A.B., Markovic-Plese, S., Martin, R., Moldenhauer, G., Wolpl, A., Sun, Y., Schadendorf, D., Hämmerling, G.J., and Kropshofer, H. (2000). Functional HLA-DM on the surface of B cells and immature dendritic cells. EMBO J. 19, 1241–1251.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bäcklund, J., Carlsen, S., Hoger, T., Holm, B., Fugger, L., Kihlberg, J., Burkhardt, H., and Holmdahl, R. (2002). Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A. 99, 9960–9965.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brand, D.D., Myers, L.K., Terato, K., Whittington, K.B., Stuart, J.M., Kang, A.H., and Rosloniec, E.F. (1994). Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine a1(II)-CB11 in H-2q mice. J. Immunol. 152, 3088–3097.

    CAS  PubMed  Google Scholar 

  • Corthay, A., Backlund, J., Broddefalk, J., Michaelsson, E., Goldschmidt, T.J., Kihlberg, J., and Holmdahl, R. (1998). Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis. Eur. J. Immunol. 28, 2580–2590.

    Article  CAS  PubMed  Google Scholar 

  • Gruber, B.L., Sorbi, D., French, D.L., Marchese, M.J., Nuovo, G.J., Kew, R.R., and Arbeit, L.A. (1996). Markedly elevated serum MMP-9 (gelatinase B) levels in rheumatoid arthritis: a potentially useful laboratory marker. Clin. Immunol. Immunopathol. 78, 161–171.

    Article  CAS  PubMed  Google Scholar 

  • Haurum, J.S., Arsequell, G., Lellouch, A.C., Wong, S.Y., Dwek, R.A., McMichael, A.J., and Elliott, T. (1994). Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J. Exp. Med. 180, 739–744.

    Article  CAS  PubMed  Google Scholar 

  • Haurum, J.S., Tan, L., Arsequell, G., Frodsham, P., Lellouch, A.C., Moss, P.A., Dwek, R.A., McMichael, A.J., and Elliott, T. (1995). Peptide anchor residue glycosylation: effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition. Eur. J. Immunol. 25, 3270–3276.

    Article  CAS  PubMed  Google Scholar 

  • Hibbs, M.S., Hoidal, J.R., and Kang, A.H. (1987). Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages. J. Clin. Invest. 80, 1644–1650.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Inaba, K., Turley, S., Iyoda, T., Yamaide, F., Shimoyama, S., Reis, Germain, R.N., Mellman, I., and Steinman, R.M. (2000). The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J. Exp. Med. 191, 927–936.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Itoh, T., Matsuda, H., Tanioka, M., Kuwabara, K., Itohara, S., and Suzuki, R. (2002). The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. J. Immunol. 169, 2643–2647.

    Article  CAS  PubMed  Google Scholar 

  • Jeffrey, J.J. (1998). Interstitial collagenases. In Matrix Metalloproteinases, W.C. Parks and R.P. Mecham, eds. Academic Press, pp. 15–42.

    Google Scholar 

  • Kjeldsen, L., Johnsen, A.H., Sengelov, H., and Borregaard, N. (1993). Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 268, 10425–10432.

    CAS  PubMed  Google Scholar 

  • Marini, S., Fasciglione, G.F., De Sanctis, G., D’Alessio, S., Politi, V., and Coletta, M. (2000). Cleavage of bovine collagen I by neutrophil collagenase MMP-8. Effect of pH on the catalytic properties as compared to synthetic substrates. J. Biol. Chem. 275, 18657–18663.

    Article  CAS  PubMed  Google Scholar 

  • Masure, S., Proost, P., Van Damme, J., and Opdenakker, G. (1991). Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8. Eur. J. Biochem. 198, 391–398.

    Article  CAS  PubMed  Google Scholar 

  • Mattu, T.S., Royle, L., Langridge, J., Wormald, M.R., Van den Steen, P.E., Van Damme, J., Opdenakker, G., Harvey, D.J., Dwek, R.A., and Rudd, P.M. (2000). O-Glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme. Biochemistry 39, 15695–15704.

    Article  CAS  PubMed  Google Scholar 

  • McQuibban, G.A., Gong, J.H., Tam, E.M., McCulloch, C.A., Clark-Lewis, I., and Overall, C.M. (2000). Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science 289, 1202–1206.

    Article  CAS  PubMed  Google Scholar 

  • Michaëlsson, E., Malmstrom, V., Reis, S., Engstrom, A., Burkhardt, H., and Holmdahl, R. (1994). T cell recognition of carbohydrates on type II collagen. J. Exp. Med. 180, 745–749.

    Article  PubMed  Google Scholar 

  • Murphy, G. and Willenbrock, F. (1995). Tissue inhibitors of matrix metalloendopeptidases. Methods Enzymol. 248, 496–510.

    Article  CAS  PubMed  Google Scholar 

  • Myers, L.K., Miyahara, H., Terato, K., Seyer, J.M., Stuart, J.M., and Kang, A.H. (1995). Collagen-induced arthritis in B10.RIII mice (H-2r): identification of an arthritogenic T-cell determinant. Immunology 84, 509–513.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Myers, L.K., Myllyharju, J., Nokelainen, M., Brand, D.D., Cremer, M.A., Stuart, J.M., Bodo, M., Kivirikko, K.I., and Kang, A.H. (2004). Relevance of posttranslational modifications for the arthritogenicity of type II collagen. J. Immunol. 172, 2970–2975.

    Article  CAS  PubMed  Google Scholar 

  • Nagase, H. and Woessner, J.F. (1999). Matrix metalloproteinases. J. Biol. Chem. 274, 21491–21494.

    Article  CAS  PubMed  Google Scholar 

  • Nguyen, Q., Murphy, G., Hughes, C.E., Mort, J.S., and Roughley, P.J. (1993). Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. Biochem. J. 295, 595–598.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ogata, Y., Enghild, J.J., and Nagase, H. (1992). Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J. Biol. Chem. 267, 3581–3584.

    CAS  PubMed  Google Scholar 

  • Opdenakker, G., Masure, S., Grillet, B., and Van Damme J. (1991). Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis. Lymphokine Cytokine. Res. 10, 317–324.

    CAS  PubMed  Google Scholar 

  • Opdenakker, G. and Van Damme, J. (1994). Cytokine-regulated proteases in autoimmune diseases. Immunol. Today 15, 103–107.

    Article  CAS  PubMed  Google Scholar 

  • Opdenakker, G., Van den Steen, P.E., and Van Damme, J. (2001). Gelatinase B: a tuner and amplifier of immune functions. Trends. Immunol. 22, 571–579.

    Article  CAS  PubMed  Google Scholar 

  • Peichl, P., Ceska, M., Effenberger, F., Haberhauer, G., Broell, H., and Lindley, I.J. (1991). Presence of NAP-1/IL-8 in synovial fluids indicates a possible pathogenic role in rheumatoid arthritis. Scand. J. Immunol. 34, 333–339.

    Article  CAS  PubMed  Google Scholar 

  • Peppin, G.J. and Weiss, S.J. (1986). Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc. Natl. Acad. Sci. U.S.A. 83, 4322–4326.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pu, Z., Carrero, J.A., and Unanue, E.R. (2002). Distinct recognition by two subsets of T cells of an MHC class II-peptide complex. Proc. Natl. Acad. Sci. U.S.A. 99, 8844–8849.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rampart, M., Herman, A.G., Grillet, B., Opdenakker, G., and Van Damme, J. (1992). Development and application of a radioimmunoassay for interleukin-8: detection of interleukin-8 in synovial fluids from patients with inflammatory joint disease. Lab. Invest. 66, 512–518.

    CAS  PubMed  Google Scholar 

  • Ribbens, C., Andre, B., Jaspar, J.M., Kaye, O., Kaiser, M.J., De Groote, D., and Malaise, M.G. (2000). Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis. J. Rheumatol. 27, 888–893.

    CAS  PubMed  Google Scholar 

  • Rosloniec, E.F., Whittington, K.B., Brand, D.D., Myers, L.K., and Stuart, J.M. (1996). Identification of MHC class II and TCR binding residues in the type II collagen immunodominant determinant mediating collagen-induced arthritis. Cell Immunol. 172, 21–28.

    Article  CAS  PubMed  Google Scholar 

  • Santambrogio, L., Sato, A.K., Carven, G.J., Belyanskaya, S.L., Strominger, J.L., and Stern, L.J. (1999). Extracellular antigen processing and presentation by immature dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 96, 15056–15061.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Seitz, M., Dewald, B., Ceska, M., Gerber, N., and Baggiolini, M. (1992). Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate. Rheumatol. Int. 12, 159–164.

    Article  CAS  PubMed  Google Scholar 

  • Senior, R.M., Griffin, G.L., Fliszar, C.J., Shapiro, S.D., Goldberg, G.I., and Welgus, H.G. (1991). Human 92-and 72-kilodalton type IV collagenases are elastases. J. Biol. Chem. 266, 7870–7875.

    CAS  PubMed  Google Scholar 

  • Sopata, I., Wize, J., Filipowicz-Sosnowska, A., Stanislawska-Biernat, E., Brzezinska, B., and Maslinski, S. (1995). Neutrophil gelatinase levels in plasma and synovial fluid of patients with rheumatic diseases. Rheumatol. Int. 15, 9–14.

    Article  CAS  PubMed  Google Scholar 

  • Sun, J.B., Olsson, T., Wang, W.Z., Xiao, B.G., Kostulas, V., Fredrikson, S., Ekre, H.P., and Link, H. (1991). Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21, 1461–1468.

    Article  CAS  PubMed  Google Scholar 

  • Triebel, S., Blaser, J., Reinke, H., and Tschesche, H. (1992). A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase. FEBS Lett. 314, 386–388.

    Article  CAS  PubMed  Google Scholar 

  • Van den Steen, P., Rudd, P.M., Dwek, R.A., and Opdenakker, G. (1998). Concepts and principles of O-linked glycosylation. Crit. Rev. Biochem. Mol. Biol. 33, 151–208.

    Article  PubMed  Google Scholar 

  • Van den Steen, P.E., Dubois, B., Nelissen, I., Rudd, P.M., Dwek, R.A., and Opdenakker, G. (2002a). Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev. Biochem. Mol. Biol. 37, 375–536.

    Article  PubMed  Google Scholar 

  • Van den Steen, P.E., Opdenakker, G., Wormald, M.R., Dwek, R.A., and Rudd, P.M. (2001). Matrix remodelling enzymes, the protease cascade and glycosylation. Biochim. Biophys. Acta 1528, 61–73.

    Article  PubMed  Google Scholar 

  • Van den Steen, P.E., Proost, P., Brand, D.D., Kang, A.H., Van Damme, J., and Opdenakker, G. (2004). Generation of Glycosylated Remnant Epitopes from Human Collagen Type II by Gelatinase B. Biochemistry 43, 10809–10816.

    Article  PubMed  Google Scholar 

  • Van den Steen, P.E., Proost, P., Grillet, B., Brand, D.D., Kang, A.H., Van Damme, J., and Opdenakker, G. (2002b). Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis. FASEB J. 16, 379–389.

    Article  PubMed  Google Scholar 

  • Van den Steen, P.E., Proost, P., Wuyts, A., Van Damme, J., and Opdenakker, G. (2000). Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. Blood 96, 2673–2681.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer

About this paper

Cite this paper

Van den Steen, P.E., Grillet, B., Opdenakker, G. (2005). Gelatinase B Participates in Collagen II Degradation and Releases Glycosylated Remnant Epitopes in Rheumatoid Arthritis. In: Axford, J.S. (eds) Glycobiology and Medicine. Advances in Experimental Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/0-387-25515-X_10

Download citation

  • DOI: https://doi.org/10.1007/0-387-25515-X_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25514-9

  • Online ISBN: 978-0-387-25515-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics