Abstract
We simulated the effects of compression of the breast on blood volume and tissue oxygenation. We sought to answer the question: how does the compression during breast examination impact on the circulatory systems of the breast tissue, namely blood flow, blood pooling, and oxygen concentration? We assumed that the blood was distributed in two compartments, arterial and venous. All the parameters were expressed with oxy- and deoxyhemoglobin quantities and were measured with a non-invasive method, Near Infrared Spectroscopy (NIRS). The simulated data showed that the blood volume pool in the breast decreased due to lower arterial flow and higher venous outflow, as the breast was squeezed under 100 cm H2O with a 10 cm diameter probe (or 78 cm2). The blood volume was reversed when the pressure was released. The breast venous oxygen saturation dropped, but overall tissue saturation (presenting NIRS signal, volume weighted average saturation) was increased. The results showed that simulation can be used to obtain venous and average oxygen saturation as well as blood flow in compressed breast tissues.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. K. Terzis, M. P. Vincent, L. M. Wilkins, K. Rutledge, and L. M. Deane, Breast sensitivity: a neurophysiological appraisal in the normal breast, Ann. Plastic Surg. 19, 318–322 (1987).
R. Novak, Transformation of the female breast during compression at mammography with special reference to the importance for localization of a lesion, Acta Radiol. 371, 41–47 (1988).
N. L Sala, E. C. Luther, J. C. Arballo, and J. C. Funes, Roles of temperature, pressure, and touch in reflex milk ejection in lactating women, J. Appl. Physiol. 37, 840–843 (1974).
W. A. Chilcote, G. A. Davis, P. Suchy, and D. M. Paushter, Breast specimen radiography: evaluation of a compression device, Radiol. 168, 425–427 (1988).
J. Shudong, B. W. Pogue, and K. D. Paulsen, In vivo near-infrared spectral detection of pressure-induced changes in breast tissue, Optics Lett. 28, 1212–1214 (2002).
P. Vaupel, S. Briest, and M. Höckel, Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications, Wiener Medizinische Wochenschrift 152, 334–342 (2002).
G. Dai, J. P. Gertler, and R. D. Kamm, The effects of external compression on venous blood flow and tissue deformation in the lower leg, J. Biomech. Eng. 121, 557–564 (1999).
A. C. Guyton, G. T. Armstrong, and P. L. Chipley, Pressure-Volume curves of the entire arterial and venous systems in the living animal, Am. J. Physiol. 184, 253–259 (1956).
V. Quaresima, S. Matcher, and M. Ferrari, Identification and quantification of intrinsic optical contrast for near-infrared mammography, Photochem. Photobiol. 67(1), 4–14 (1998).
A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. Berger, D. Hsiang, J. Butler, R. F. Holocombe, and B. J. Tromberg, Spectroscopy enhances the information content of optical mammography, J. Biomed. Opt. 7, 60–71 (2002).
B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterberg, U. L. Osterberg, and K. D. Paulsen, Quantitative hemoglobin tomography with diffuse near infrared spectroscopy: pilot results in the breast, Radiol. 218, 261–266 (2001).
J. Zhang, Y. Lin, S. Nioka, N. O’Connor, B. Czemiecki, E. F. Conant, and B. Chance, Application of LED imager for breast cancer diagnosis, Proc. SPIE 4916, 30–36 (2002).
T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chanee, and A. G. Yodh, Bulk optical properties of healthy female breast tissue, Phys. Med Biol. 47, 2847–2861 (2002).
S. Nioka, S. Yung, M. Shnall, S. Zhao, S. Orel, C. Xie, B. Chance, and L. Solin, Optical imaging of breast tumor by means of continuous waves, Adv. Exp. Med. Biol. 411, 227–232 (1997).
S. Nioka, S. B. Colak, X. Li, and B. Chance, Breast tumor images of hemodynamic information using a contrast agent with back projection and FFT enhancement, OSA TOPS, Adv. Opt. Imag. Photon Migration 21, 266–270 (1998).
X. Intes, J. Ripoll, Y. Chen, S. Nioka, A. Yodh, and B. Chance, In vivo continuous-wave optical breast imaging enhanced with indocyanine green, Med. Phys. 30, 1039–1047 (2003).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Nioka, S. et al. (2005). Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation. In: Okunieff, P., Williams, J., Chen, Y. (eds) Oxygen Transport to Tissue XXVI. Advances in Experimental Medicine and Biology, vol 566. Springer, Boston, MA. https://doi.org/10.1007/0-387-26206-7_3
Download citation
DOI: https://doi.org/10.1007/0-387-26206-7_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25062-5
Online ISBN: 978-0-387-26206-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)