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Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA

  • Chapter
Zinc Finger Proteins

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

The wig-1 gene (for Wild type p53-Induced Gene 1) is a direct transcriptional target of wild type p53. Wig-1 is a highly conserved unusual nuclear zinc finger protein that binds double stranded RNA. Overexpression of Wig-1 inhibits cell growth. Wig-1 has been implicated in neuronal apoptosis and stem cell proliferation/differentiation. Elucidation of the biological function of Wig-1 should provide new insights into the p53 tumor suppressor pathway.

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Authors and Affiliations

  1. Department of Oncology and Pathology Karolinska Institute, Cancer Center Karolinska (CCK), Stockholm, Sweden

    Cristina Mendez-Vidal, Fredrik Hellborg, Margareta T. Wilhelm, Magdalena Tarkowska & Klas G. Wiman

Authors
  1. Cristina Mendez-Vidal
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  2. Fredrik Hellborg
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  3. Margareta T. Wilhelm
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  4. Magdalena Tarkowska
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  5. Klas G. Wiman
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Editor information

Editors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

    Shiro Iuchi

  2. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Natalie Kuldell

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© 2005 Landes Bioscience/Eurekah.com and Kluwer Academic/Plenum Publishers

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Mendez-Vidal, C., Hellborg, F., Wilhelm, M.T., Tarkowska, M., Wiman, K.G. (2005). Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_12

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