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The BTB Domain Zinc Finger Proteins

  • Chapter
Zinc Finger Proteins

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The BTB/zinc finger proteins have a wide range of functions in development and homeostasis and a wide range of interactions. The BTB domain appears essential for these proteins to dimerize, facilitate DNA looping, form specific multi-protein structures in the nucleus and interact with co-repressor molecules. The BTB domains of the proteins differ in their affinity for co-repressors and contribution to the transcriptional activity of the proteins. The BTB domain also allows interaction with other BTB proteins perhaps by forming higher order multimers and a network of BTB interactions likely exists. All of the BTB/zinc finger proteins have other important functional domains. PLZF and Bcl6 have a second repression domain, while Miz-1 has an important activation domain internal to the protein. In addition, the zinc fingers of these proteins can interact with co-factors implicated in transcriptional activity as well as nuclear cytoplasmic shuttling. Lastly given the recent information indicating the importance of the BTB domain in ubiquitylation pathways the BTB/zinc finger proteins may also play a role in degradation of specific proteins in the cell. Whether this is related to or distinct from their transcriptional functions remains to be discovered.

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Authors and Affiliations

  1. Department of Medical Biophysics, University of Toronto & Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Ontario, Canada

    Gilbert G. Privé & K. Farid Ahmad

  2. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

    Ari Melnick

  3. Division of Hematology and Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA

    Jonathan D. Licht

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  1. Gilbert G. Privé
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  1. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

    Shiro Iuchi

  2. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Natalie Kuldell

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Privé, G.G., Melnick, A., Ahmad, K.F., Licht, J.D. (2005). The BTB Domain Zinc Finger Proteins. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_20

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