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Differential Expression of Ca Channels and Synaptic Transmission in Normal and Ataxic Knock-Out Mice

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Pumps, Transporters, and Ion Channels

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6. References

  • Adler, E.M., Augustine, G.J., Duffy, S.N., and Charlton, M.P., 1991, Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse, Journal of Neuroscience 11(6): 1496–1507.

    Google Scholar 

  • Ambrosini, A., Maertens de Noordhout, A, Alagona, G., Dalpozzo, F., and Schoenen, J., 1999, Impairment of neuromuscular transmission in a subgroup of migraine patients, Neuroscience Letters 276: 201–203.

    Google Scholar 

  • Bimbaumer, L., Qin, N., Olcese, R., Tareilus, E., Platano, D., Costantin, J., and Stefani, E., 1998, Structures and functions of calcium channel beta subunits, Journal of Bioenergetics Biomembranes 4: 357–375.

    Article  Google Scholar 

  • Catterall, W.A., 1998, Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release, Cell Calcium 24(5/6): 307–323

    Article  Google Scholar 

  • Cull-Candy, S.G., Miledi, R., Trautmann, A., and Uchitel, O.D., 1980, On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end-plates, Journal of Physiology (London) 299:621–638.

    Google Scholar 

  • Dodge, F.A., and Rahamimoff, R., 1967, Co-operative action a calcium ions in transmitter release at the neuromuscular junction, Journal of Physiology (London) 193: 419–432.

    Google Scholar 

  • Doyle, J., Ren, X., Lennon, G., and Stubbs, L., 1997, Mutations in the Cacnlla4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice, Mammalian Genome 8: 113–120.

    Article  Google Scholar 

  • Ertel, E.A, Campbell, K.P., Harpold, M.M., Hofmann, F., Mori, Y., Perez-Reyes, E., Schwartz, A., Snutch, T.P., Tanabe, T., Birnbaumer, L., Tsien, R.W., and Catterall, W.A., 2000, Nomenclature of voltage-gated calcium channels, Neuron 25: 533–535

    Article  Google Scholar 

  • Fletcher, C.F., Lutz, C.M., O’Sullivan, T.N., Shaughnessy, J.D., Jr., Hawkes, R., Frankel, W.N., Copeland, N.G., and Jenkins, N.A., 1996, Absence epilepsy in tottering mutant mice is associated with calcium channel defects, Cell 87(4): 607–617.

    Article  Google Scholar 

  • Hans, M., Luvisetto, S., Williams, M.E., Spagnolo, M., Urrutia, A., Tottene, A., Brust, P.F., Jhonson, E.C., Harpold, M.M., Staurderman, K.A., and Pietrobon, D., 1999, Functional consequences of mutations in the human alphal A calcium channel subunit linked to familial hemiplegic migraine, Journal of Neuroscience 19: 1610–1619.

    Google Scholar 

  • Jen, J., 1999, Calcium channelopathies in the central nervous system, Current Opinion in Neurobiology 9(3): 274–280.

    Article  Google Scholar 

  • Jun, K., Piedras-Renteria, E.S., Smith, S.M., Wheeler, D.B., Lee, S.B., Lee, T.G., Chin, H., Adams, M.E., Scheller, R.H., Tsien, R.W., and Shin, H.-S., 1999, Ablation of P/Q-type Ca2+ channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the ω1A-subunit, Proceedings of the National Acaddemy of Sciences U.S.A., 96(26): 15245–15250

    Article  ADS  Google Scholar 

  • Katz, B., 1969, The release of neural transmitter substances, Sherrington lectures, No 10, Liverpool University Press.

    Google Scholar 

  • Katz, E., Protti, D.A., Ferro, P.A., Rosato-Siri, M.D., and Uchitel, O.D., 1997, Effects of Ca2+ channel blocker neurotoxins on transmitter release and presynaptic currents at the mouse neuromuscular junction, British Journal of Pharmacology 121: 1531–1540.

    Article  Google Scholar 

  • Kraus, R.L., Sinnegger, M.J., Glossmann, H., Hering, S., and Striessnig, J., 1998, Familial hemiplegic migraine mutations change alpha 1A Ca2+ channel kinetics, Journal of Biological Chemistry 273(10): 5586–5590.

    Article  Google Scholar 

  • Llinás, R., and Moreno H., 1998, Local Ca2+ signaling in neurons, Cell Calcium 2: 359–366.

    Article  Google Scholar 

  • Llinás, R., Steinberg, I.Z., and Walton, K., 1976, Presynaptic calcium currents and their relation to synaptic transmission: Voltage clamp study in squid giant synapse and theoretical model for the calcium gate, Proceedings of the National Academy of Sciences U.S.A., 73: 2918–2922.

    Article  ADS  Google Scholar 

  • Nyholt, D.R., Dawkins, J.L., Brimage, P.J., Goadsby, P.J., Nicholson, G.A., and Griffiths, L.R., 1998, Evidence for an X-linked genetic component in familial typical migraine, Human Molecular Genetics 7: 459–463.

    Article  Google Scholar 

  • Ophoff, R.A., Terwindt, G.M., Frants, R.R., and Ferrari, M.D., 1998, P/Q-type Ca2+ channel defects in migraine, ataxia and epilepsy, Trends in Pharmacological Sciences 19: 121–127.

    Article  Google Scholar 

  • Protti, D.A., and Uchitel, O.D., 1993, Transmitter release and presynaptic Ca2+ currents blocked by the spider toxin ω-Aga-IVA, NeuroReport 5: 333–336

    Article  Google Scholar 

  • Reuter, H., 1996, Diversity and function of presynaptic calcium channels in the brain, Current Opinion in Neurobiology 6: 331–337.

    Article  Google Scholar 

  • Rosato-Siri, M.D., and Uchitel, O.D., 1999, Calcium channels coupled to neurotransmitter release at neonatal rat neuromuscular junctions, Journal of Physiology (London) 514: 533–540.

    Article  Google Scholar 

  • Terwindt, G.M., Ophoff, R.A., Haan, J., Sandkuijl, L.A., Frants, R.R., and Ferrari, M.D., 1998, Migraine, ataxia and epilepsy: a challenging spectrum of genetically determined calcium channelopathies, European Journal of Human Genetics 6: 297–307.

    Article  Google Scholar 

  • Toru, S., Murakoshi, T., Ishikawa, K., Saegusa, H., Fujigasaki, H., Uchihara, T., Nagayama, S., Osanai, M., Mizusawa, H., and Tanabe, T., 1999, Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function, Journal of Biological Cemistry 275(15): 10893–10898.

    Article  Google Scholar 

  • Uchitel, O.D., 1997, Toxins affecting calcium channels in neurons, Toxicon 35(8): 1161–1191.

    Article  Google Scholar 

  • Urbano, F.J., Depetris, R.S., and Uchitel, O.D., 2001, Coupling of L-type calcium channels to neurotransmitter release at mouse motor nerve terminals, Pflugers Archiv 441(6): 824–831.

    Article  Google Scholar 

  • Uchitel, O.D., Protti, D.A., Sánchez, V., Cherksey, B.D., Sugimori, M., and Llinás, R., 1992, P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses, Proceedings of the National Academy of Sciences U.S.A., 89: 3330–3333.

    Article  ADS  Google Scholar 

  • Urbano, F.J., Piedras-Rentería, E., Tsien, R.W., and Uchitel, O.D., 2001, Short term facilitation and Ca2+ dependence of transmitter release are altered at the neuromuscular junction of P/Q Ca2+ channel knock out mice, Biophysical Journal 80(l):234a.

    Google Scholar 

  • Urbano, F.J., and Uchitel, O.D., 1999, L-type calcium channels unmasked by cell-permeant Ca2+ buffer at mouse motor nerve terminals, Pflugers Archiv 437(4): 523–528.

    Article  Google Scholar 

  • Zhuchenko, O., Bailey, J., Bonnen, P., Ashizawa, T., Stockton, D.W., Amos, C, Dobyns, W.B., Subramony, S.H., Zoghbi, H.Y., and Lee, C.C., 1997, Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1 A-voltage-dependent calcium channel, Nature Genetics 15(l):62–69.

    Article  Google Scholar 

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Urbano, F.J., Rosato-Siri, M.D., Uchitel, O.D. (2005). Differential Expression of Ca Channels and Synaptic Transmission in Normal and Ataxic Knock-Out Mice. In: Sepúlveda, F.V., Bezanilla, F. (eds) Pumps, Transporters, and Ion Channels. Series of the Centro de Estudios Científicos. Springer, Boston, MA. https://doi.org/10.1007/0-387-27424-3_8

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