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Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease

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Gene Therapy of Autoimmune Diseases

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

One of the most exciting advances in the field of gene therapy in recent years is the establishment of the antigen-specific T cell as a vector for the delivery of genetically-derived treatment in vivo. In contrast with traditional applications of gene therapy, the unique versatility, specificity and memory of the T cell affords the researcher or clinician the ability to apply a broad range of tactics in the genetic treatment of disease. The T cell may be modified to deliver therapeutic products or regenerative products to sites of inflammation and tissue destruction. In addition, the T cell may be altered to modulate cellular interactions or to correct its own genetic defects to ameliorate disease. These genetic modification strategies as they relate to the treatment of autoimmune disease in experimental animal models will be the focus of this chapter, with particular emphasis on the analogs of multiple sclerosis (MS), insulin-dependent diabetes mellitus (IDDM) and rheumatoid arthritis (RA).

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Authors and Affiliations

  1. Department of Immunology, NB30, The Cleveland Clinic Foundation, Lerner Research Instititute, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA

    Justin M. Johnson & Vincent K. Tuohy

Authors
  1. Justin M. Johnson
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  2. Vincent K. Tuohy
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Johnson, J.M., Tuohy, V.K. (2005). Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease. In: Gene Therapy of Autoimmune Diseases. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-28670-5_4

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