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Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction

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Proteases and Their Inhibitors in Cancer Metastasis

Part of the book series: Cancer Metastasis — Biology and Treatment ((CMBT,volume 4))

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Abstract

Proteinases play a central role in the complex response of tissues to injury by influencing cellular behavior and matrix remodeling. Considerable information on the biology of proteinases has been derived from gene targeting and gene transfer studies. One of the best characterised proteinase systems is the plasminogen system, belonging to the large serine proteinase family. Using mice with a targeted deficiency of plasminogen system components, it has become obvious that the plasminogen system can — directly or indirectly by activation of matrix metalloproteinases — have divergent — even opposite — roles in disease favoring healing in some cases and promoting tissue destruction in others. This Chapter discusses the mechanisms by which the plasminogen system can influence the response to injury in the vessel wall, the heart, the nervous system, the lungs and the skin.

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Authors and Affiliations

  1. The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, B-3000, Belgium

    A. Luttun & P. Carmeliet

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  1. A. Luttun
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  2. P. Carmeliet
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  1. Laboratoire de Biologie des Tumeurs et du Développement, Faculté de Médecine Université de Liège, Belgium

    Jean-Michel Foidart

  2. Department of Pathology & Laboratory Medicine, University of Pennsylvania, USA

    Ruth J. Muschel

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© 2002 Kluwer Academic Publishers

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Luttun, A., Carmeliet, P. (2002). Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction. In: Foidart, JM., Muschel, R.J. (eds) Proteases and Their Inhibitors in Cancer Metastasis. Cancer Metastasis — Biology and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2008-2_1

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  • DOI: https://doi.org/10.1007/1-4020-2008-2_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-0923-5

  • Online ISBN: 978-1-4020-2008-7

  • eBook Packages: Springer Book Archive

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