Skip to main content

The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis

  • Chapter
Proteases and Their Inhibitors in Cancer Metastasis

Part of the book series: Cancer Metastasis — Biology and Treatment ((CMBT,volume 4))

  • 118 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguirre Ghiso JA, Alonso DF, Farias EF, Gomez DE, Bal de Kier Joffe E. Deregulation of the signaling pathways controlling urokinase production. Eur J Biochem 1999; 263: 295–304.

    Article  CAS  PubMed  Google Scholar 

  • Airola K, Karonen T, Vaalamo M, Lehti K, Lohi J, Kariniemi AL, Keski-Oja J, Saarialho-Kee U. Expression of collagenases-1 and-3 and their inhibitors TIMP-1 and-3 correlates with the level of invasion in malignant melanomas. Br J Cancer 1999; 80: 733–743.

    Article  CAS  PubMed  Google Scholar 

  • Allgayer H, Babic R, Beyer BC, Grutzner KU, Tarabichi A, Schildberg FW, Heiss MM. Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer. Oncology 1998; 55: 152–160.

    Article  CAS  PubMed  Google Scholar 

  • Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A, Muschel RJ. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells a new model for metastasis. Nature Med 2000; 6: 100–102.

    CAS  PubMed  Google Scholar 

  • Bae RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer K-J, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nature Med 1997; 3: 447–450.

    Google Scholar 

  • Balbin M, Pendas AM, Uria JA, Jimenez MG, Freije JP, Lopez-Otin C. Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors. APMIS 1999; 107: 45–53.

    CAS  PubMed  Google Scholar 

  • Baldini N. Multidrug resistance — a muliplex phenomenon. Nature Med 1997; 3: 378–380.

    CAS  PubMed  Google Scholar 

  • Bando E, Yonemura Y, Endou Y, Sasaki T, Taniguchi K, Fujita H, Fushida S, Fujimura T, Nishimura G, Miwa K, Seiki M. Immunohistochemical study of MT-MMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis. Oncol Rep 1998; 5: 1483–1488.

    CAS  PubMed  Google Scholar 

  • Barrett AJ, Starkey PM. The interaction of alpha-2-macroglobulin with proteases. Biochem J 1973; 133: 709–724.

    CAS  PubMed  Google Scholar 

  • Basset P, Okada A, Chenard M-P, Kannan R, Stoll I, Anglard P, Bellocq J-P, Rio M-C. Matrix metalloproteinases as stromal effectors of human carcinoma progression therapeutic implications. Matrix Biol 1997; 15: 535–541.

    Article  CAS  PubMed  Google Scholar 

  • Basuyaux JP, Ferreira E, Stehlin D, Buttice G. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and independent manner. J Biol Chem 1997; 272: 26188–26195.

    Article  CAS  PubMed  Google Scholar 

  • Benbow U, Brinckerhoff CE. The AP-1 site and MMP gene regulation what is all the fuss about? Matrix Biology 1997; 15: 519–526.

    Article  CAS  PubMed  Google Scholar 

  • Benbow U, Schoenermark MP, Mitchell TI, Rutter JL, Shimokawa K, Nagase H, Brinckerhoff CE. A novel host/tumor cell interaction activates matrix metalloproteinase 1 and mediates invasion through type I collagen. J Biol Chem 1999; 274: 25371–25378.

    Article  CAS  PubMed  Google Scholar 

  • Benbow U, Schoenermark MP, Orndorff KA, Given AL, Brinckerhoff CE. Human breast cancer cells activate procollagenase-1 and invade type I collagen invasion is inhibited by all-trans retinoic acid. Clin Exp Metastasis 1999; 17: 213–238.

    Article  Google Scholar 

  • Bjorn SF, Hastrup N, Lund LR, Dano K, Larsen JF, Pyke C. Co-ordinated expression of MMP-2 and its putative activator MT1-MMP in human placentation. Mol Hum Reprod 1997; 8: 713–723.

    Google Scholar 

  • Borden P, Solymjar D, Swcharczuk A, Lindman B, Cannon P, Heller RA. Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes. J Biol Chem 1996; 271: 23577–23581.

    CAS  PubMed  Google Scholar 

  • Borden P, Heller RA. Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Critical Reviews in Eukaryotic Gene Expression 1997; 7: 159–178.

    CAS  PubMed  Google Scholar 

  • Buolamwini JK. Novel anticancer drug discovery. Current Opin Chem Biol 1999; 3: 500–509.

    CAS  Google Scholar 

  • Buttice G, Duterque-Coquillaud M, Basuyaux JP, Carrere S, Kurkinen M, Stehlin D. Erg an Ets-family member differentially regulates human collagenase-1 (MMP-1) and stromelysin-1 (MMP-3) expression by physically interacting with the Fos/Jun complex. Oncogene 1996; 9: 2241–2246.

    Google Scholar 

  • Cawston T, Plumpton T, Curry V, Ellis A, Powell L. Role of TIMP and MMP inhibition in preventing connective tissue breakdown. Ann NY Acad Sci 1994; 732: 75–83.

    CAS  PubMed  Google Scholar 

  • Chambers AF, Matrisian LA. Changing views on the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997; 89: 1260–1270.

    Article  CAS  PubMed  Google Scholar 

  • Curran S, Murray GI. Matrix metallo-proteinases in tumor invasion and metastasis. J Pathol 1999; 189: 300–308.

    Article  CAS  PubMed  Google Scholar 

  • Dolo V, Ginestra A, Cassara D, Violini S, Lucania G, Torrisi MR, Nagase H, Canevari S, Pavan A, Vitorelli ML. Selective localization of matrix metalloproteinase 9 beta1 integrins and human lymphocyte antigen class I molecules on membrane vesicles shed by 8701-BC breast cancer cells. Cancer Res 1998; 58: 4468–4474.

    CAS  PubMed  Google Scholar 

  • Driouch K, Briffod M, Bieche I, Champeme M-H, Lidereau R. Location of several putative genes possibly involved in human breast cancer progression. Cancer Res 1998; 58: 2081–2086.

    CAS  PubMed  Google Scholar 

  • Durko M, Navab R, Shibata HR, Brodt P. Suppression of basement membrane type IV collagen degradation and cell invasion in human melanoma cells expressing an antisense RNA for MMP-1. Biochem Biophys Acta 1997; 1356: 271–280.

    CAS  PubMed  Google Scholar 

  • Durko M, Brodt N. Suppression of type I collagenase expression by antisense RNA in melanoma cells results in reduced synthesis of the urokinase-type plasminogen activator receptor. Biochem Biophys Res Communications 1998; 247: 342–348.

    CAS  Google Scholar 

  • Ellenrieder V, Alber B, Lacher U, Hendler SF, Menke A, Boeck W, Wagner M, Wilda M, Friess H, Buchler M, Adler G, Gress TM. Role of MT-MMPs and MMP-2 in pancreatic cancer progression. Int J Cancer 2000; 85: 14–20.

    Article  CAS  PubMed  Google Scholar 

  • Fang J, Shing Y, Wiederschain D, Yan L, Butterffield C, Jackson G, Harper J, Tamvakopoulos G, Moses MA. Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proc Natl Acd Sci (USA) 2000; 97: 3884–3889.

    CAS  ADS  Google Scholar 

  • Freije JMP, Diez-Itza I, Balbin M, Sanchez LM, Blasco R, Tolivia J, Lopez-Otin C. Molecular cloning and expression of collagenase-3 a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem 1994; 269: 16766–16773.

    CAS  PubMed  Google Scholar 

  • Gilhardi G, Bioni ML, Mangoni J, Leviti S, DeMonti M, Guagnellini E, Scorza R. Matrix Metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness. Clin Cancer Res 2001; 7: 2344–2346.

    Google Scholar 

  • Gilles C, Pollete M, Piette J, Munaut C, Thompson EW, Birembaut P, Foidart JM. High level of MT-MMP expression is associated with invasiveness of cervical cancer cells. Int J Cancer 1996; 65: 209–231.

    Article  CAS  PubMed  Google Scholar 

  • Gilles C, Polette M, Birembaut P, Brunner N, Thompson EW. Expression of c-ets-1 mRNA is associated with an invasive EMT-derived phenotype in breast carcinoma lines. Clin Exp Metastasis 1997; 5: 519–526.

    Google Scholar 

  • Ginestra A, La Placa MD, Saladino F, Cassara D, Nagase H, Vittorelli ML. The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res 1998; 18: 3433–3437.

    CAS  PubMed  Google Scholar 

  • Ginestra A, Micell D, Dolo V, Romano FM, Vitorelli ML. Membrane vesicles in ovarian cancer fluids a new potential marker. Anticancer Res 1999; 19: 3439–3945.

    CAS  PubMed  Google Scholar 

  • Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson U. Tissue inhibitors of metalloproteinases structure regulation and biologic functions. Eur J Cell Biol 1997; 7: 111–122.

    Google Scholar 

  • Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition relationship to bone and cartilage degradation. Bone 1998; 22: 33–38.

    PubMed  Google Scholar 

  • Guo H, Zucker S, Gordon MK, Toole BP, Biswas C. Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells. J Biol Chem 1997; 272: 24–27.

    CAS  PubMed  Google Scholar 

  • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353–364.

    Article  CAS  PubMed  Google Scholar 

  • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57–70.

    Article  CAS  PubMed  Google Scholar 

  • Haq M, Shafli A, Zervos EE, Rosemurgy AS. Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer. Cancer Res 2000; 60: 3207–3211.

    CAS  PubMed  Google Scholar 

  • Heimbrook DC, Oliff A. Therapeutic intervention and signaling. Current Opin Cell Biology 1998; 10: 284–288.

    CAS  Google Scholar 

  • Heppner KJ, Matrisian LM, Jensen RA, Rodgers WH. Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol 1996; 149: 273–282.

    CAS  PubMed  Google Scholar 

  • Hotary K, Allen E, Punturieri A, Yana I, Weiss SJ. Regulation of cell invasion and morphogenesis in a three-dimentional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2 and 3. J Cell Biology 2000; 149: 309–1323.

    Article  Google Scholar 

  • Imamura T, Ohshio G, Mise M, Harada T, Suwa H, Wang Z, Yoshitomi S, Tanaka T, Sata S, Arii S, Seiki M, Imamura M. Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas. J Cancer Res Clin Oncol 1998; 124: 65–72.

    Article  CAS  PubMed  Google Scholar 

  • Inoue T, Yashiro M, Nishimura S, Maeda K, Sawada T, Ogawa Y, Sowa M, Chung KH. Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer. Int J Mol Med 1999; 4: 73–77.

    CAS  PubMed  Google Scholar 

  • Ishigake S, Toi M, Ueno T, Matsumoto H, Muta M, Koike M, Seiki M. Significance of membrane type I matrix metalloproteinase expression in breast cancer. Jpn J Cancer Res 1999; 90: 516–522.

    Google Scholar 

  • Issing WJ, Wustrow TP. Expression of retinoic acid receptors in squamous cell carcinoma and their possible implications for chemoprevention. Anticancer Res 1996; 16: 2373–2377.

    CAS  PubMed  Google Scholar 

  • Ito T, Ito M, Shiozawa J, Naito S, Kanematsu T, Sekine I. Expression of the MMP-1 in human pancreatic carcinoma relationship with prognostic factor. Mod Pathol 1999; 12: 669–674.

    CAS  PubMed  Google Scholar 

  • Jimenez MJ, Balbin M, Lopez JM, Alvarez J, Komori T, Lopez-Otin C. Collagenase-3 is a target of Cbfa1 a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 1999; 19: 4431–4442.

    CAS  PubMed  Google Scholar 

  • Johansson N, Vaalamo M, Grenman S, Hietanen S, Klemi P, Saarialho-Kere U, Kahari VM. Collagenase-3 (MMP-13) is expressed by tumor cells in invasive squamous cell carcinomas. Am J Pathology 1999; 154: 469–480.

    CAS  Google Scholar 

  • Kahari VM, Johansson N, Grenman R, Airola K, Saarialho-Kere U. Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck. Adv Exp Med Biol 1998; 451: 63–68.

    CAS  PubMed  Google Scholar 

  • Kanamori Y, Matsushima M, Minaguchi T, Kobayashi K, Sagae S, Kudo R, Terakawa N, Nakamura Y. Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region. Cancer Res 1999; 59: 4225–4227.

    CAS  PubMed  Google Scholar 

  • Kim J, Yu W, Kovalski K, Ossowski L. Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell 1999; 94: 353–362.

    Google Scholar 

  • Kitagawa Y, Kunimi K, Ito H, Sato H, Uchibayashi T, Okada Y, Seiki M, Namiki M. Expression and tissue localization of membrane-types 1, 2 and 3 matrix metalloproteinases in human urothelial carcinomas. J Urol 1998; 160: 1540–1545.

    CAS  PubMed  Google Scholar 

  • Kitagawa Y, Kunimi K, Uchibayashi T, Sato H, Namiki M. Expression of messenger RNAs for membrane-type 1, 2 and 3 matrix metalloproteinases in human renal cell carcinomas. J Urol 1999; 162: 905–909.

    Article  CAS  PubMed  Google Scholar 

  • Kjellman M, Enberg U, Hoog A, Larsson C, Holst M, Farebo LO, Sato H, Backdahl M. Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA expressed in adrenocortical cancers but not in adenomas. World J Surgery 1999; 23: 237–242.

    CAS  Google Scholar 

  • Koblinski JA, Abrahram A, Sloane BF. Unraveling the role of proteases in cancer. Clin Chim Acta 2000; 291: 113–135.

    Article  CAS  PubMed  Google Scholar 

  • Koochekpour S, Jeffers M, Wang PH, Gong C, Taylor GA, Roessler LM, Stearman R, Vasselli JR, Stetler-Stevenson WG, Kaelin WG, Linehan WM, Klausner RD, Gnarra JR, Vande Woude GF. The von-Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol Cell Biol 1999; 19:5902–5912.

    CAS  PubMed  Google Scholar 

  • Kuniyasu H, Ellis LM, Evans DB, Abbruzzese JL, Fenoglio CJ, Bucana CD, Cleary KR, Tahara E, Fidler IJ. Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. Clin Cancer Res 1999; 5: 23–33.

    Google Scholar 

  • Kurahara S, Shinohara M, Ikebe T, Nakamura S, Beppu M, Hiraki A, Takeuchi H, Shirasuna K. Expression of MMPs MT-MMP and TIMPs in squamous cell carcinoma of the oral cavity correlation with tumor invasion and metastasis. Head Neck 1999; 21: 627–638.

    CAS  PubMed  Google Scholar 

  • Li H, Bauzon DE, Xu X, Tschesche H, Cao J, Sang QA. Immunological characterization of cell-surface and soluble forms of membrane type I matrix metalloproteinase in human breast cancer cells and in fibroblasts. Mol Carcinog 1998; 22: 84–89.

    Article  CAS  PubMed  Google Scholar 

  • Lotan R. Retinoids and their receptors in modulation of differentiation development and prevention of head and neck cancers. Anticancer Res 1996; 16: 15–19.

    Google Scholar 

  • Lovejoy B, Welch AR, Carr S, Luong C, Broka C, Hendricks RT, Campbell JA, Walker KAM, Martin R, Van Wort H, Browner MF. Crystal structures of MMP-1 and-13 reveal the structural basis for selectivity of collagenase inhibitors. Nature Struct Biol 1999; 6: 217–221.

    CAS  PubMed  Google Scholar 

  • Lui K, Wahlberg P, Ny T. Coordinated and cell-specific regulation of membrane type metalloproteinase 1 (MT1-MMP) and its substrate matrix metalloproteinase 2 (MMP-2) by physiologic signals during follicular development and ovulation. Endocrinology 1998; 139: 4735–4738.

    Google Scholar 

  • Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LMG, Peíer J, Trent JM, Meltzer PS, Hendrix MJC. Vascular channel formation by human melanoma cells in vivo and in vitro vasculogenic mimicry. Am J Pathol 1999; 155: 739–752.

    CAS  PubMed  Google Scholar 

  • McCawley LJ, Matrisian LM. Matrix metalloproteinases multifunctional contributors to tumor progression. Mol Med Today 2000; 6: 149–156.

    CAS  PubMed  Google Scholar 

  • Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38 c-jun N-terminal kinase and nuclear factor kB. Arthritis Rheum 2000; 43: 801–811.

    Article  CAS  PubMed  Google Scholar 

  • Mitchell PG, Magna HA, Reeves LM. Cloning expression and type II collagenolytic activity of matrix metalloproteinase 13 from human osteoarthritic cartilage. J Clin Invest 1996; 97: 2011–2019.

    Google Scholar 

  • Moser PL, Kieback DG, Hefler L, Tempfer C, Neunteufel W, Gitsch G. Immuno-histochemical detection of matrix metalloproteinases (MMP) 1 and 2 and tissue inhibitor of metalloproteinases 2 (TIMP 2) in stage I and II endometrial cancer. Anticancer Res 1999; 19: 236–2367.

    Google Scholar 

  • Murray GI, Duncan ME, O’Neil P, Melvin WT, Fothergill JE. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nature Med 1996; 2: 461–462.

    CAS  PubMed  Google Scholar 

  • Murray GI, Duncan ME, OÌNeil P, McKay JA, Melvin WT, Fothergill JE. Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 1998p 185: 256–261.

    Article  CAS  PubMed  Google Scholar 

  • Nagase H, Itoh Y, Binner S. Interaction of alpha2 macroglobulin with matrix metalloproteinases and its use for identification of their active forms. Ann NY Acad Sci 1994; 6: 294–302.

    Google Scholar 

  • Nagase H, Woessner JF Jr. Matrix Metalloproteinases. J Biol Chem 1999; 274: 21491–21492.

    Article  CAS  PubMed  Google Scholar 

  • Nakopoulou L, Giannopoulou I, Gakiopoulou H, Liapis H, Tzonou A, Davaris PS. Matrix metalloproteinase-1 and-3 in breast cancer correlation with progesterone receptors and other clinicopathological feature. Hum Pathol 1999; 30: 436–442.

    Article  CAS  PubMed  Google Scholar 

  • Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases biologic activity and clinical implications. J Clin Oncol 2000; 18: 1135–1149.

    CAS  PubMed  Google Scholar 

  • Nishioka Y, Kobayashi K, Sagae S, Ishioka S, Nishikawa A, Matsushima M, Kanamori Y, Minaguchi T, Nakamura Y, Tokina T, Kudo R. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter in endometrial carcinomas. Jpn J Cancer Res 2000; 91: 612–615.

    CAS  PubMed  Google Scholar 

  • Noll WW, Belloni DR, Rutter JL, Storm CA, Schned AR, Titus-Ernstoff L, Ernstoff MS, Brinckerhoff CE. Loss of heterozygosity on chromosome 11q.22.23 in melanoma is associated with retention of the insertion polymorphism in the matrix metalloproteinase 1 promoter. Am J Pathol 2001; 158: 691–697.

    CAS  PubMed  Google Scholar 

  • Oberg A, Hoyhtya M, Tavelin B, Stenling R, Lindmark G. Limited value of preoperative serum analyses of matrix metalloproteinases (MMP-2 MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 TIMP-2) in colorectal cancer. Anticancer Res 2000; 20: 1085–1091.

    CAS  PubMed  Google Scholar 

  • O-Charoenrat P, Rhys-Evans P, Mldjtahedi H, Court W, Box G, Eccles S. Overexpression of epidermal growth factor receptor in head and neck squamous cell carcinoma cell lines correlates with matrix metallo-proteinase-9 expression and in vitro invasion. Int J Cancer 2000; 86: 307–317.

    Article  CAS  PubMed  Google Scholar 

  • Ohishi K, Fujita N, Morinaga Y, Tsuruo T. H-32 human breast cancer cells stimulate type I collagenase production in osteoblast-like cells and induce bone resorption. Clin Exp Metastasis 1995; 13: 287–295.

    Article  CAS  PubMed  Google Scholar 

  • Ohuchi E, Imai K, Fuji Y, Sato H, Seiko M, Okada Y. Membrane type I matrix metalloproteinase digest interstitial collagens and other extracellular matrix macromolecules. J Biol Chem 1997; 272: 2446–2451.

    CAS  PubMed  Google Scholar 

  • Parsons SL, Watson SA, Brown PD, Collins HM, Steele RJC. Matrix Metalloproteinases. Br J Surgery 1997; 84: 60–166.

    Google Scholar 

  • Pei D. Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J Biol Chem 1999; 274: 8925–8932.

    CAS  PubMed  Google Scholar 

  • Pendas AM, Balbin M, Llano E, Jimenez MG, Lopez-Otin C. Structural analysis and promoter characterization of the human collagenase-3 gene (MMP-13). Genomics 1997; 40: 222–233.

    Article  CAS  PubMed  Google Scholar 

  • Pendas AM, Uria J, Jimenez MG, Balbin M, Freije JP, Lopez-Otin C. An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies. Clin Chem Acta 2000; 291: 137–155.

    CAS  Google Scholar 

  • Pickett KL, Harber GJ, DeCarlo AA, Louis P, Shaneyfelt S, Windsor LJ, Bodden MK. 72K-GL (MMP-9) and 92K-GL (MMP-2) are produced in vivo by human oral squamous cell carcinomas and can enhance FIB-CL (MMP-1) activity in vitro. J Dent Res 1999; 78: 1354–1361.

    CAS  PubMed  Google Scholar 

  • Polette M, Birembaut P. Membrane-type metalloproteinases in tumor invasion. Int J Biochem Cell Biochem 1998; 30: 1195–1202.

    CAS  Google Scholar 

  • Ramos-deSimone N, Hahn-Dantona E, Sipley J, Nagase H, French DL, Quigley JP. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 1999; 274: 3066–13076.

    Google Scholar 

  • Rasmussen HS, McCann PP. Matrix metalloproteinase inhibition as a novel anticancer strategy a review with special focus on Batimastat and Marimastat. Pharmacol Ther 1997; 75: 69–75.

    Article  CAS  PubMed  Google Scholar 

  • Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. The new collagenase collagenase-3 is expressed and synthesized by human chondrocytes but not by synoviocytes. J Clin Invest 1996; 97: 2011–2019.

    CAS  PubMed  Google Scholar 

  • Remacle AG, Noel A, Duggan C, McDermott E, O’Higgins N, Foidart JM, Duffy MJ. Assay of matrix metalloproteinases types 1, 2, 3 and 9 in breast cancer. Br J Cancer 1998; 77: 926–931.

    CAS  PubMed  Google Scholar 

  • Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransferase a strategic target for anticancer therapeutic development. J Clin Oncol 1999; 17: 3631–3652.

    CAS  PubMed  Google Scholar 

  • Rutter JL, Mitchell TI, Buttice G, Meyers J, Gusella JF, Ozelius LJ, Brinckerhoff CE. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res 1998; 58: 5321–5325.

    CAS  PubMed  Google Scholar 

  • Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM. c-Fos is required for malignant progression of skin tumors. Cell 1995; 82: 721–732.

    Article  CAS  PubMed  Google Scholar 

  • Sato T, Iwai M, Sakai T, Sato H, Seiki M, Mori Y, Ito A. Enhancement of membrane-type I-matrix metalloproteinase (MT1-MMP) production and subsequent activation of progelatinase A on human squamous cell carcinoma cells co-cultured with human dermal fibroblasts. Br J Cancer 1999; 80: 1137–1143.

    CAS  PubMed  Google Scholar 

  • Schadendorf D, Kern MA, Artuc M, Pahl HL, Rosenbach T, Fichtner I, Nurnberg W, Stuting S, von Stebut E, Worm M, Makki A, Jurgovsky K, Kolde G, Benz BM. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro and causes cell growth inhibition in xenografts in vivo. J Cell Biology 1996; 135: 1889–1898.

    Article  CAS  Google Scholar 

  • Schoenermark MP, Mitchell TI, Rutter JL, Reczek PR, Brinckerhoff CE. Retinoid-mediated inhibition of tumor invasion and matrix metalloproteinase synthesis. Ann NY Acad Sci 1999; 878: 66–486.

    Google Scholar 

  • Schroen DJ, Brinckerhoff CE. Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms. Gene Expression 1997; 6: 197–207.

    Google Scholar 

  • Seiki M. Membrane-type matrix metalloproteinases. APMIS 1999; 107: 137–143.

    CAS  PubMed  Google Scholar 

  • Shalinsky DR, Brekken J, Zou H, McDermott CD, Forsyth P, Edwards D, Margosiak S, Benber S, Truitt G, Wood A, Varki NM, Appelt K. Broad anti-tumor and anti-angiogenic activities of AG3340 a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann NY Acad Sci 1999; 878: 236–270.

    CAS  PubMed  Google Scholar 

  • Spanjaard RA, Ikeda M, Lee PJ, Charpentier B, Chin WW, Eberlein T. Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RAR γ in induction of differentiation and apoptosis in S91 melanoma cells. J Biol Chem 1997; 27: 18990–18999.

    Google Scholar 

  • Stetler-Stevenson WG. Matrix metalloproteinases in angiogenesis a moving target for therapeutic intervention. J Clin Invest 1999; 103: 1237–1241.

    CAS  PubMed  Google Scholar 

  • Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Ogden A, Shepherd L, Willman C, Bloomfield CD, Rowe JM, Wiernik PH. All-trans-retinoic acid in acute promyelocytic leukemia. N Eng J Med 1997; 337: 1021–1028.

    CAS  Google Scholar 

  • Talvensaari-Mattila A, Paakko P, Hoyhtya M, Blanco-Sequeriros G, Turpeenniemi-Hujanen T. Matrix metalloproteinase-2 immunoreactive protein a marker of aggressiveness in breast carcinoma. Cancer 1998; 83: 1153–1162.

    Article  CAS  PubMed  Google Scholar 

  • Tanney DC, Feng L, Pollock AS, Lovett DH. Regulated expression of matrix metalloproteinases and TIMP in nephrogenesis. Dev Dyn 1998; 213: 121–129.

    Article  CAS  PubMed  Google Scholar 

  • Tardiff G, Pelletier J-P, Dupuis M, Hambor JE, Martel-Pelletier J. Cloning sequencing and characterization of the 5’-flanking region of the human collagenase-3 gene. Biochem J 1997: 32313–32316.

    Google Scholar 

  • Tsukifuji R, Tagawa K, Hatamouchi A, Shinkai H. Expression of matrix metalloproteinase-1-2 and-3 in squamous cell carcinoma and actinic keratosis. Br J Cancer 1999; 8: 10878–10891.

    Google Scholar 

  • Uitto VJ, Airola K, Vaalamo M, Johansson N, Putnins EE, Firth JD, Salonen J, Lopez-Otin C, Saarialho-Kere U, Kahari VM. Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. Am J Pathol 1998; 152: 1489–1499.

    CAS  PubMed  Google Scholar 

  • Unemori EN, Ferrara N, Bauer EA, Amento EP. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cellular Physiol 1992; 153: 557–562.

    CAS  Google Scholar 

  • Vaisanen A, Kallioinen M, Taskinen PJ, Turpeenniemi-Hujanen T. Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma. J Pathol 1998; 186: 51–58.

    CAS  PubMed  Google Scholar 

  • Vaisanen A, Kallioinen M, von Dickhoff K, Laatikainen L, Hoytya M, Turpeenniemi-Hujanen T. Matrix metalloproteinase-2 (MMP-2) immunoreactive protein — a new prognostic marker in uveal melanoma? J Pathol 1999; 188: 56–62.

    CAS  PubMed  Google Scholar 

  • Vaalamo M, Mattila L, Johansson N, Kariniemi AL, Kajalainen-Lindsberg ML, Kahari VM, Saarialho-Kere U. Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. J Invest Dermatol 1997; 109: 96–101.

    Article  CAS  PubMed  Google Scholar 

  • Velesco G, Cal S, Merlos-Suarez A, Ferrando AA, Alverez S, Nakano A, Arribas J, Lopez-Otin C. Human MT6-matrix metalloproteinase identification progelatinase A activation and expression in brain tumors. Cancer Res 2000; 60: 877–882.

    Google Scholar 

  • Vincenti MP, Clark IM, Brinckerhoff CE. Using inhibitors of metalloproteinases to treat arthritis easier said than done? Arthritis and Rheum 1994; 37: 1115–1126.

    CAS  Google Scholar 

  • Vincenti MP, White LA, Schroen DJ, Benbow U, Brinckerhoff CE. Regulating expression of the gene for matrix metalloproteinase-1 (collagenase) mechanisms that control enzyme activity transcription and mRNA stability. Critical Reviews in Eucaryotic Gene Expression 1996; 6: 391–411.

    CAS  Google Scholar 

  • Vincenti MP, Coon CI, Brinckerhoff CE. Nuclear factor kB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in Interleukin-1? stimulated synovial fibroblasts. Arthritis Rheum 1998; 4: 1981–994.

    Google Scholar 

  • Vu TH, Shipley JM, Bergers, Berger JE, Helms JA, Hanahan D, Shipiro SD, Senior RM, Werb Z. MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 1998; 93: 411–422.

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Keiser J. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle. Circ Res 1998; 157: 5–12.

    CAS  Google Scholar 

  • Wasylyk B, Hahn SL, Giovane A. The Ets family of transcription factors. Eur J Biochem 1993; 15: 7–18.

    Google Scholar 

  • Wen W, Moses MA, Wiederschain D, Arbiser JL, Folkman J. The generation of endostatin is mediated by elastase. Cancer Res 1999; 59: 6052–6056.

    CAS  PubMed  Google Scholar 

  • Westermarck J, Kahari V-M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999; 13: 781–792.

    CAS  PubMed  Google Scholar 

  • White LA, Brinckerhoff CE. Two AP-1 elements in the collagenase promoter have differential effects on transcription and bind JunD c-Fos and Fra-2. Matrix Biology 1995; 14: 715–725.

    Article  CAS  PubMed  Google Scholar 

  • Wojtowicz-Praga S, Low J, Marshall J, Ness E, Dickson R, Barter J, Sale M, McCann P, Moore J, Cole A, Hawkins MJ. Phase I trial of a novel matrix metalloproteinase inhibitor Batimastat (BB-94). Invest New Drugs 1996; 14: 193–202.

    Article  CAS  PubMed  Google Scholar 

  • Wojtowicz-Praga S, Torri J, Johnson M, Steen V, Marshall J, Nese E, Dickson R, Sale M, Rasmussen HS, Chiodo TA, Hawkins MJ. Phase I trial of Marimastat a novel matrix metalloproteinase inhibitor administered orally to patients with advanced lung cancer. J Clin Oncol 1998; 16: 2150–2156.

    CAS  PubMed  Google Scholar 

  • Wosikowski K, Schuurhuis D, Geert JP, Kops JPL, Saceda M, Bates SE. Altered gene expression in drug-resistant human breast cancer cells. Clinical Cancer Res 1997; 3: 2405–2414.

    CAS  Google Scholar 

  • Ye S, Dhillon S, Turner SJ, Bateman AC, Theaker JM, Pickering RM, Day I, Howell WM. Invasiveness of cutaneous malignant melanoma is influenced by Matrix Metalloproteinase 1 gene polymorphism. Cancer Res 2001; 61: 1296–1298.

    CAS  PubMed  Google Scholar 

  • Yoon S-S, Fidler IJ, Beltran PJ, Bucana CD, Wang Y-F, Fan D. Intratumor heterogeneity for and epigenetic modulation of mdr-1 expression in murine melanoma. Melanoma Res 1997; 7: 275–287.

    CAS  PubMed  Google Scholar 

  • Zhang XK, Liu Y, Lee MO. Retinoic receptors in human lung cancer and breast cancer. Mutation Res 1996; 350: 267–277.

    CAS  PubMed  Google Scholar 

  • Zhu Y, Spitz MR, Lei L, Mills GB, Wu X. A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter enhances lung cancer susceptibility. Cancer Res 2001; 61: 7825–7829.

    CAS  PubMed  Google Scholar 

  • Zimmerman CM, Padgett RW. Transforming growth factor beta signaling mediators and modulators. Gene 2000; 16: 17–30.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Brinckerhoff, C.E., Benbow, U., Tower, G.B. (2002). The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis. In: Foidart, JM., Muschel, R.J. (eds) Proteases and Their Inhibitors in Cancer Metastasis. Cancer Metastasis — Biology and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2008-2_4

Download citation

  • DOI: https://doi.org/10.1007/1-4020-2008-2_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-0923-5

  • Online ISBN: 978-1-4020-2008-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics