Abstract
A phylogeny of the Arf family of proteins has been constructed using sequence data available from the complete (or nearly complete) genomes of six model eukaryotic species; including three animals, two fungi and a protist. Our analyses reveal distinct groupings of three Arf and ten Arl (Arf-like) subfamilies. These Arf and Arl subfamilies have arisen by numerous gene duplications that took place at different times during eukaryotic evolution. Some apparently young subfamilies are comprised of proteins found only in animals, while older families include members from all of the eukaryotic lineages considered. Available functional information for these proteins is considered in light of their evolutionary relationships.
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Logsdon, J.M., Kahn, R.A. (2004). The Arf Family Tree. In: ARF Family GTPases. Proteins and Cell Regulation, vol 1. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2593-9_1
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DOI: https://doi.org/10.1007/1-4020-2593-9_1
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