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Mammalian DNA Damage Response Pathway

  • Chapter
Genome Instability in Cancer Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 570))

Conclusions

The DNA damage response pathway is critical for the maintenance of genomic stability. Many components of this pathway are tumour suppressors, such as p53, ATM, BRCA1, NBS1, Mre11 and Chk2, underlining the critical role of the DNA damage response pathway in tumour suppression. The elucidation of the DNA damage response pathway will not only help us understand the mechanism of tumour suppression, but also allow for the discovery of new drug targets for cancer therapy. A recent example is the development of MDM2 inhibitors that could activate the p53 pathway in cancer cells (Vassilev et al., 2004). With the help of proteomics and advances in imaging techniques, we should have a better understanding of the molecular events mediating the DNA damage response in the near future.

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Authors and Affiliations

  1. Department of Oncology, Mayo Clinic and Foundation, Rochester, USA

    Zhenkun Lou & Junjie Chen

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  1. Zhenkun Lou
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  2. Junjie Chen
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Editors and Affiliations

  1. Max-Planck Institute of Biochemistry, Martinsried, Germany

    Erich A. Nigg

  2. State University of New York, Buffalo

    Nathan Back

  3. The Weizmann Institute of Science, Israel

    Irun R. Cohen

  4. Wistar Institute, USA

    David Kritchevsky

  5. N. S. Kline Institute for Psychiatric Research, USA

    Abel Lajtha

  6. University of Milan, Italy

    Rodolfo Paoletti

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Lou, Z., Chen, J. (2005). Mammalian DNA Damage Response Pathway. In: Back, N., Cohen, I.R., Kritchevsky, D., Lajtha, A., Paoletti, R., Nigg, E.A. (eds) Genome Instability in Cancer Development. Advances in Experimental Medicine and Biology, vol 570. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3764-3_15

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