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Motility in Tumor Invasion and Metastasis — An Overview

  • Chapter
Cell Motility in Cancer Invasion and Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 8))

Abstract

Most cancer morbidity and mortality derives from the dissemination of the tumor cells and subsequent growth in ectopic locations. Local invasion of adjacent normal tissue and adnexia compromise homeostatic functions and prevent surgical or radiological extirpation of the tumor. Recent investigations highlight the central role that induced motility plays in promoting this spread. Metastatic seeding and growth, that dramatically increase tumor burden and relegate local therapies, require additional complex acquired behaviors including resistance to anoikis and shear stresses. Still, tumor cell motility and associated biophysical processes such as adhesion modulation, are central to this terminal progression. Our growing understanding of the function of motility, and key molecular switches that govern this behavior, provide new targets for rationale therapeutics aimed at arresting tumors in their tracks.

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  1. Department of Pathology, Pittsburgh VA Medical Center and University of Pittsburgh, Pittsburgh, PA, USA

    Alan Wells

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  1. Department of Pathology, Pittsburgh VAMC, University of Pittsburgh, PA, USA

    Alan Wells

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Wells, A. (2006). Motility in Tumor Invasion and Metastasis — An Overview. In: Wells, A. (eds) Cell Motility in Cancer Invasion and Metastasis. Cancer Metastasis - Biology and Treatment, vol 8. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4009-1_1

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