Abstract
The efficacy against lethality and post-intoxication incapacitation after 2x LD50 soman of different subacute pretreatment scenarios of 12 days was tested with or without post-intoxication therapy in guinea pigs. These pretreatment regimes were 1) the currently used pyridostigmine (PYR, 0.04 mg/kg/hr), 2) the combination of physostigmine (PHY, 0.025 mg/kg/hr) with the muscarinic receptor antagonist scopolamine (SCO, 0.018 mg/kg/hr), and 3) the combination of PHY with the anti-Parkinson drug procyclidine (PC, 3 mg/kg, sc). The post-intoxication therapy consisted of HI-6 (21.4 mg/kg, im), atropine sulphate (AS, 0.085 mg/kg, im), and diazepam (DZP, 0.21 mg/kg, im). Behavioral and observational read-out systems were used to elucidate the severity of soman induced incapacitation.
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Philippens, I.H., Jongsma, M.J., Vanwersch, R.A. (2006). EFFICACY OF PRETREATMENT AND TREATMENT AGAINST SOMAN INTOXICATION. In: Dishovsky, C., Pivovarov, A., Benschop, H. (eds) Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack. NATO Security Through Science Series, vol 1. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4170-5_13
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DOI: https://doi.org/10.1007/1-4020-4170-5_13
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