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Nutritional Deficiency and its Modulation in Old Age

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Prevention and Treatment of Age-related Diseases
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Abstract

This chapter covers physiological roles, dietary requirements and deficiencies associated to macronutrients and micronutrients in older people. It has been postulated that mitochondrial failure and oxidative stress are major events in cell aging and death. Nutritional modulation of mitochondria and antioxidant activities of nutrients and other bioactive compounds from functional foods help to reduce the risk of chronic diseases of aging

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References

  • Ames, B.N., Shigenaga, M.K. and Hagen, T.M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci., 90: 7915–7922.

    PubMed  CAS  Google Scholar 

  • Arivazhagan, P., Ramanathan, K. and Panneerselvam, C. (2001) Effect of DL-alpha-lipoic acid on mitochondrial enzymes of aged rats. Chem Biol Inter., 138: 189–198.

    CAS  Google Scholar 

  • Armeni, T., Principato, G., Quiles, J.L., Pieri, C., Bompadre, S., Battino, M. (2003) Mitochondrial dysfunction during aging: vitamin E deficiency or caloric restriction-two different ways of modulating stress. J Bionerg Biomembr., 35: 181–91.

    CAS  Google Scholar 

  • Atamna, H., Liu, J., Ames, B.N. (2001) Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts. Relevance to aging. J Biol Chem., 276: 48410–48416.

    PubMed  CAS  Google Scholar 

  • Barja, G., Cadenas, S., Rojas, C., Perez-Campo, R. and Lopez-Torres, M. (1994) Low mitochondrial free radical production per unit O_2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds. Free Rad Res., 21: 317–327.

    CAS  Google Scholar 

  • Barja, G. (1998) Mitochondrial free radical production and aging in mammals and birds. Ann NY Acad Sci., 854: 224–238.

    PubMed  CAS  Google Scholar 

  • Bates, C.J., Benton, D., Biesalski, H.K., et al. (2002). Nutrition and aging: a consensus statement. J Nutr Health Aging, 6: 103–116.

    PubMed  CAS  Google Scholar 

  • Beck, M.A. (2001) Antioxidants and Viral Infections: Host Immune Response and Viral Pathogenicity. J Am Coll Nutr., 20(suppl): 384S–388S.

    PubMed  CAS  Google Scholar 

  • Berger, A. (2002) Science commentary: what does zinc do? BMJ, 325: 1062–1063.

    PubMed  Google Scholar 

  • Berr, C. (2000) Cognitive impairment and oxidative stress in the elderly: Results of epidemiological studies. BioFactors, 13: 205–209.

    PubMed  CAS  Google Scholar 

  • Binienda, Z.K. (2003) Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction. Ann NY Acad Sci., 993: 289–295.

    PubMed  CAS  Google Scholar 

  • Block, G., Mangels, A.R., Norkus, E.P., Patterson, B.H., Levander, O.A. and Taylor P.R. (2001) Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension, 37: 261–267.

    PubMed  CAS  Google Scholar 

  • Broekmans, W.M.R., Klöpping-Ketelaars, I.A.A., Schuurman, C.R.W.C., et al. (2000) Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans. J Nutr., 130: 1578–1583.

    PubMed  CAS  Google Scholar 

  • Brown, K.M., Morrice, P.C. and Duthie G.G. (1998) Erythrocyte membrane fatty acid composition of smokers and non-smokers: effects of vitamin E supplementation. Eur J Clin Nutr., 52: 145–150.

    PubMed  CAS  Google Scholar 

  • Calle, E.E., Rodriguez, C., Walker-Thurmond, K. and Thun, M.J. (2003) Overweight, obesity and mortality from cancer in a prospectively studied cohort of US adults. New Engl J Med., 348: 1625–1638.

    PubMed  Google Scholar 

  • Cardoso, S.M., Pereira, C. and Oliveira, C. (1999) Mitochondrial function is differentially affected upon oxidative stress. Free Rad Biol Med., 26: 3–13.

    PubMed  CAS  Google Scholar 

  • Cho, E., Seddon, J.M., Rosner, B., Willett, W.C. and Hankinson, S.E. (2004) Prospective study of intake of fruits, vegetables, vitamins, and carotenoids, and risk of age-related maculopathy. Arch Ophtalmol., 122: 883–892.

    Google Scholar 

  • Cuajungco, M.P., Fagét, K.Y., Huang, X., Tanzi, R.E. and Bush, A.I. (2000) Metal chelation as a potential therapy for Alzheimer’s disease. Ann NY Acad Sci., 920: 292–304.

    PubMed  CAS  Google Scholar 

  • Cui, J., Cordis, G.A., Tosaki, A. et al. (2002) Reduction of myocardial ischemia reperfusion injury with regular consumption of grapes. Ann NY Acad Sci, 957: 302–307.

    PubMed  CAS  Google Scholar 

  • Driver, C. (2003) Mitochondrial interventions in aging and longevity. In: Modulating aging and longevity. Biology of aging and its modulation v.5 (ed. Rattan, S.I.S.) Pages 205–217, Kluwer Academic Publishers, Dordrecht, The Netherlands.

    Google Scholar 

  • Durlach, J., Pagés, N., Bac, P., Bara, M. and Guiet-Bara, A. (2004) Magnesium research: from begginings to today. Magnes Res., 17: 163–168.

    PubMed  CAS  Google Scholar 

  • Duthie, G.G. (1993) Lipid peroxidation. Eur J Clin Nutr., 47: 759–764.

    PubMed  CAS  Google Scholar 

  • Engelhart, M.J., Geerlings, M.I., Ruitenberg, A., et al. (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA, 287: 3223–3229.

    PubMed  CAS  Google Scholar 

  • Ferrari, C.K.B. (1998) Oxidação lipídica em alimentos e sistemas biológicos: mecanismos gerais e conseqüências nutricionais e patológicas. Rev Nutr., 11: 3–14.

    CAS  Google Scholar 

  • Ferrari, C.K.B. (1999) Oxidação de gorduras em alimentos: produção de substâncias tóxicas na dieta do homem. Rev Instit Hig Med Soc., 3: 22–26.

    Google Scholar 

  • Ferrari, C.K.B. (2000) Free radicals, lipid peroxidation and antioxidants in apoptosis: implications in cancer, cardiovascular and neurological diseases. Biologia, 55: 581–590.

    CAS  Google Scholar 

  • Ferrari, C.K.B. (2001) Oxidative stress pathophysiology: Searching for an effective antioxidant protection. Int Med J., 8: 175–184.

    CAS  Google Scholar 

  • Ferrari, C.K.B. (2004) Functional foods, herbs, and nutraceuticals: Towards biochemical mechanisms of healthy aging. Biogerontol., 5: 275–289.

    CAS  Google Scholar 

  • Ferrari, C.K.B, and Torres, E.A.F.S. (2002) Novos compostos com propriedades anticarcinogênicas. Rev Bras Cancerol., 48: 375–382.

    Google Scholar 

  • Ferrari, C.K.B. and Torres, E.A.F.S. (2003) Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomed Pharmacother., 57: 251–260.

    PubMed  CAS  Google Scholar 

  • Fontaine, K.R., Redden, D.T., Wang, C., Westfall, A.O. and Allison, D.B. (2003) Years of life lost due to obesity. JAMA, 289: 187–193.

    PubMed  Google Scholar 

  • Ford, E.S. and Mokdad, A.H. (2001) Fruit and vegetable consumption and diabetes mellitus incidence among U.S. adults. Prev Med., 32: 33–39.

    CAS  Google Scholar 

  • Fox, C., Ramsoomair, D. and Carter, C. (2001) Magnesium: its proven and potential clinical significance. South Med J., 94: 1195–1201.

    PubMed  CAS  Google Scholar 

  • Franceschi, C. and Bonafé, M. (2003) Centenarians as a model for healthy aging. Biochem Soc Transact., 31: 457–461.

    CAS  Google Scholar 

  • Fraser, G.E. (1999) Nut consumption, lipids, and risk of coronary event. Clin Cardiol., 22(7suppl.): III11–15.

    PubMed  CAS  Google Scholar 

  • Freedman, J.E., Parker, C., Li, L., et al. (2001) Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation, 103: 2792–2798.

    PubMed  CAS  Google Scholar 

  • Garrett, R.H. and Grisham, C.M. (1995) Biochemistry. Saunders College Publ., Orlando, 1995.

    Google Scholar 

  • Grievink, L., Smith, H.A., Ocké, M.C., van’t Veer, P. and Kromhout, D. (1998) Dietary intake of the antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the Morgen Study. Thorax, 53: 166–171.

    PubMed  CAS  Google Scholar 

  • Gutteridge, J.M. (1995). Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem., 41: 1819–1828.

    PubMed  CAS  Google Scholar 

  • Hagen, T.M., Ingersoll, R.T., Wehr, C.M., et al. (1998) Acetyl-L-carnitine fed to old rats partially restored mitochondrial function and ambulatory activity. Proc Natl Acad Sci., 95: 9562–9566.

    PubMed  CAS  Google Scholar 

  • Halliwell, B. (1994). Free radicals and antioxidants: a personal view. Nutr Rev., 52: 253–265.

    PubMed  CAS  Google Scholar 

  • Hamilton, C.A., Brosnan, J., McIntyre, M., Graham, D and Dominiczak, A.F. (2001) Superoxide excess in hypertension and aging. Hypertension, 37: 529–534.

    PubMed  CAS  Google Scholar 

  • He, K., Rimm, E.B., Merchant, A., et al. (2002) Fish consumption and risk of stroke in men. JAMA, 288: 3130–3136.

    PubMed  CAS  Google Scholar 

  • Heber, D. (2004) Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med., 50: 145–149.

    PubMed  Google Scholar 

  • Heys, S.D., Schofield, A.C. and Wahle, K.W. (2004) Immunonutrition in clinical practice: what is the current evidence? Nutr Hosp., 19: 325–332.

    PubMed  CAS  Google Scholar 

  • Horrocks, L.A. and Farooqui, A.A. (2004) Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural embrane function. Prostagl Leukot Essent Fatty Acid., 70: 361–372.

    CAS  Google Scholar 

  • Hu, F.B., Stampfer, M.J., Manson, J.E., et al. (1998) Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ, 317: 1341–1345.

    PubMed  CAS  Google Scholar 

  • Hughes, D.A. (2000) Dietary antioxidants and human immune function. Nutr Bul., 25: 35–41.

    Google Scholar 

  • Ishii, N., Senoo-Matsuda, N., Miyake, K., et al. (2004) Coenzyme Q10 prolong C. elegans lifespan by lowering oxidative stress. Mech Ageing Dev., 125: 41–46.

    CAS  Google Scholar 

  • Kamat, J.P. and Devasagayam, T.P.A. (2000) Oxidative damage to mitochondria in normal and cancer tissues, and its modulation. Toxicology, 155: 73–82.

    PubMed  CAS  Google Scholar 

  • Kelloff, G.J., Crowell, J.A., Steele, V.E., et al. (2000) Progress in cancer chemoprevention: Development of diet-derived chemopreventive agents. J Nutr., 130: 467S–471S.

    PubMed  CAS  Google Scholar 

  • Kelso, G.F., Porteous, C.M., Coulter, C.V., et al. (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells. J Biol Chem., 276: 4588–4596.

    PubMed  CAS  Google Scholar 

  • Kim, G.W., Kondo, T., Noshita, N. and Chan, P.H. (2002) Manganse superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke, 33: 809–815.

    PubMed  CAS  Google Scholar 

  • Knekt, P., Järvinen, R., Reunanen, A. and Maatela, J. (1996) Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ, 312: 478–481.

    PubMed  CAS  Google Scholar 

  • Ku, H.H. and Sohal, R.S. (1993) Comparison of mitochondrial pro-oxidant generation and antioxidant defenses between rat and pigeon: possible basis for variation in longevity and metabolic potential. Mech Aging Dev., 72: 67–76.

    PubMed  CAS  Google Scholar 

  • Larsson, N.-G. and Luft, R. (1999) Revolution in mitochondrial medicine. FEBS Lett., 455: 199–202.

    PubMed  CAS  Google Scholar 

  • Lebovitz, R.M., Zhang, H., Vogel, H., et al. (1996) Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci., 93: 9782–9787.

    PubMed  CAS  Google Scholar 

  • Lenaz, G. (1998) Role of mitochondria in oxidative stress and ageing. Biochim Biophys Acta, 1366: 53–67.

    PubMed  CAS  Google Scholar 

  • Levander, O.A. (2000) The selenium-coxsackievirus connection: chronicle of a collaboration. J Nutr., 130: 485S–488S.

    PubMed  CAS  Google Scholar 

  • Linnane, A.W., Marzuki, S., Osawa, T. and Tanaka, M. (1989) Mitochondrial DNA mutations as an important contribution to ageing and degenerative diseases. The Lancet, I: 642–645.

    Google Scholar 

  • Lipkin, M. (1999) Preclinical and early human studies of calcium and colon cancer prevention. Ann NY Acad Sci., 889: 120–127.

    PubMed  CAS  Google Scholar 

  • Liu, J., Head, E., Gharib, A.M., et al. (2002) Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversed by feeding acetyl-L-carnitine and/or R-α-lipoic acid. Proc Natl Acad Sci., 99: 2356–2361.

    PubMed  CAS  Google Scholar 

  • Lukaski, H.C. (2004) Vitamin and mineral status: effects on physical performance. Nutriton, 20: 632–644.

    CAS  Google Scholar 

  • Lyle, B.J., Mares–Perlman, J.A., Klein, B.E.K., et al. (1999) Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. Am J Clin Nutr., 69: 272–277.

    PubMed  CAS  Google Scholar 

  • Möller, P., Wallin, H. and Knudsen, L.E. (1996) Oxidative stress associated with exercise, psychological stress and life-style factors. Chem-Biol Inter., 102: 17–36.

    Google Scholar 

  • Mahoney, D.J., Parise, G. and Tarnopolsky, M.A. (2002) Nutritional and exercise-based therapies in the treatment of mitochondrial disease. Curr Opin Clin Nutr Metab Care, 5: 619–629.

    PubMed  CAS  Google Scholar 

  • Matthews, R.T., Yang, L., Browne, S., Baik, M. and Beal, F. (1998) Coenzyme Q10 adminstration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci., 95: 8892–8897.

    PubMed  CAS  Google Scholar 

  • McKeown, N.M., Meigs, J.B., Liu, S., Wilson, P.W.F. and Jacques P.F. (2002) Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr., 76: 390–398.

    PubMed  CAS  Google Scholar 

  • Mecocci, P., Polidori, M.C., Troiano, L., et al. (2000) Plasma antioxidants and longevity: a study on healthy centenarians. Free Rad Biol Med., 28: 1243–1248.

    PubMed  CAS  Google Scholar 

  • Michels, K.B. and Ekbom, A. (2004) Caloric restriction and incidence of breast cancer. JAMA, 291: 1226–1230.

    PubMed  CAS  Google Scholar 

  • Morley, J.E. (2004) Nutrition and aging. Nutritional assessment outline. In: Preventing ADL decline in nursing homes. Process improvement manual. Pages 1–5, NCHCQF, Saint Louis University, School of Medicine, St. Louis, USA.

    Google Scholar 

  • Morley, J.E. (2004) The top 10 hot topics in aging. J Gerontol., 59: 24–33.

    Google Scholar 

  • Néve, J. (2002) Selenium as a ‘nutraceutical’: how to conciliate physiological and supra-nutritional effects for an essential trace element. Curr Opin Nutr Metab Care, 5: 659–663.

    Google Scholar 

  • Namura, S., Nagata, I., Takami, S. et al. (2001) Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke, 32: 1906–1911.

    PubMed  CAS  Google Scholar 

  • Nappo, F., De Rosa, N., Marfella, R. et al. (1999) Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA, 281: 2113–2118.

    PubMed  CAS  Google Scholar 

  • Padma, V.V. and Devi, C.S. (2002) Effect of fish oil on mitochondrial respiration in isoproterenol induced myocardial infarction in rats. Indian J Exp Biol., 40: 268–272.

    PubMed  CAS  Google Scholar 

  • Pahor, M. and Applegate, W.B. (1997) Recent advances: geriatric medicine. BMJ, 315: 1071–1074.

    PubMed  CAS  Google Scholar 

  • Paolisso, G., Barbieri, M., Rizzo, M.R. (2001) Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes. Exp Gerontol., 37: 149–156.

    PubMed  CAS  Google Scholar 

  • Pawelec, G., Barnett, Y., Forsey, R., et al. (2002) T cells and aging, January 2002 update. Front Biosci., 7: d1056–d1183.

    PubMed  CAS  Google Scholar 

  • Pedrosa, L.F.C. and Cozzolino, S.M.F. (1999) Alterações metabólicas e funcionais do cobre em diabetes mellitus. Rev Nutr., 12: 213–224.

    CAS  Google Scholar 

  • Pepe, S., Tsuchiya, N., Lakatta, E.G. and Hansford, R.G. (1999) PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2 + aactivation of PDH. Am J Physiol., 45: H149–H158.

    Google Scholar 

  • Perkins, A.J., Hendrie, H.C., Callahan, C.M., et al. (1999) Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey. Am J Epidemiol., 150: 37–44.

    PubMed  CAS  Google Scholar 

  • Perls, T. and Terry, D (2003) Understanding the determinants of exceptional longevity. Ann Intern Med., 139: 445–449.

    PubMed  Google Scholar 

  • Pioro, E.P. (2000) Antioxidant therapy in ALS. ALS Motor Neuron Dis., 1 (Suppl 4): 5–15.

    CAS  Google Scholar 

  • Rafique, R., Shapira, A.H. and Coper, J.M. (2004) Mitochondrial respiratory chain dysfunction in ageing; influence of vitamin E deficiency. Free Radic Res., 38: 157–165.

    PubMed  CAS  Google Scholar 

  • Ramalingaswami, V. (1992) Una vitamina y dos elementos minerals, claves de la salud. Foro Mund Salud, 13: 220–229.

    Google Scholar 

  • Rattan, S.I.S. (2003a) Biology of aging and possibilities of gerontomodulation. Proc Indian Nat Sci Acad., B69: 157–164.

    Google Scholar 

  • Rattan, S.I.S. (ed.) (2003b) Modulating aging and longevity. Biology of aging and its modulation v5. Kluwer Academic Publishers, Dordrecht, The Netherlands.

    Google Scholar 

  • Richard, M.-J. and Roussel, A.-M. (1999) Micronutrients and ageing: intakes and requirements. Proc Nutr Soc., 58: 573–578.

    PubMed  CAS  Google Scholar 

  • Rosenfeldt, F.L., Pepe, S., Linnane, A., et al. (2002) Coenzyme Q10 protects the aging heart against oxidative stress. Studies in rats, human tissues, and patients. Ann NY Acad Sci., 959: 355–359.

    CAS  Google Scholar 

  • Rossi, L., Lippe, G., Marchese, E., et al. (1998) Decrease of cytochrome c oxidase protein in heart of mitochondria of copper-deficient rats. Biometals, 11: 207–212.

    PubMed  CAS  Google Scholar 

  • Sato, Y. (2000) Diabetes and life-styles: role of physical exercise for primary prevention. Brit J Nutr., 84(suppl.2): S187–S190.

    PubMed  CAS  Google Scholar 

  • Schrauzer, G.N. (2000) Anticarcinogenic effects of selenium. Cel Mol Life Sci., 57: 1864–1873.

    CAS  Google Scholar 

  • Sheard, N.F. (1998) Fish consumption and risk of sudden cardiac death. Nutr Rev., 56: 177–179.

    PubMed  CAS  Google Scholar 

  • Smith, M.A., Petot, G.J. and Perry, G. (1999) Diet and oxidative stress: a novel synthesis of epidemiological data no Alzheimer’s disease. J Alzheim Dis., 1: 203–206.

    CAS  Google Scholar 

  • Sohmiya, M., Tanaka, M., Suzuki, Y., Tanino, Y., Okamoto, K. and Yamamoto, Y. (2005) An increase of oxidized coenzyme Q-10 in the plasma of sporadic ALS patients. J Neurol Sci., 228: 49–53.

    PubMed  CAS  Google Scholar 

  • Somer, E. (2003) Nutrition basics. In: Nutrition for women. 2nd ed., Pages 14–39, OWL Books, New York.

    Google Scholar 

  • Suh, J.H., Shigeno, E.T., Morrow, J.D., et al. (2001) Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-α-lipoic acid. Faseb J., 15: 700–706.

    PubMed  CAS  Google Scholar 

  • Tabak, C., Arts, I.C.W., Smith, H.A., Heederik, D. and Kromhout, D. (2001) Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones. Am J Respir Crit Care Med., 164: 61–64.

    PubMed  CAS  Google Scholar 

  • Tanguy, S., Toufektsian, M.-C., Besse, S., Ducros, V., Leiris, J. de and Boucher, F. (2003) Dietary selenium intake affects cardiac susceptibility to ischemia/reperfusion in male senescent rats. Age Ageing, 32: 273–278.

    PubMed  Google Scholar 

  • Thaler, D.E., Hope, R.A. and Longmore, J.M. (1999) Oxford handbook of clinical medicine. Oxford University Press, New York, 1999.

    Google Scholar 

  • Tong, G.M. and Rude, R.K. (2005) Magnesium deficiency and critical illness. J Intens Care Med., 20: 3–17.

    Google Scholar 

  • Tornero, D., Ceña, V. and Jordán, J. (2002) La mitocondria como diana farmacológica en los procesos neurodegenerativos. Offarm, 21: 98–102.

    Google Scholar 

  • Trichopoulou, A. and Vasilopoulou, E. (2000) Mediterranean diet and longevity. Brit J Nutr., 384 (Suppl 2): 205–209.

    Google Scholar 

  • Trichopoulou, A., Orfanos, P., Norat, T., et al. (2005) Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ, 330: 991.

    PubMed  Google Scholar 

  • Viña, J., Sastre, J., Pallardó, F.V. and Bonás, C. (2004) Posibles mecanismos por los que las mujeres viven más que los varones. Rev Esp Geriatr Gerontol., 39: 381–384.

    Google Scholar 

  • Virmani, A., Gaetani, F., Imam, S., Binienda, Z. and Ali, S. (2003) Possible mechanism for the neuroprotective effects of L-carnitine on methamphetamine-evoked neurotoxicity. Ann NY Acad Sci., 993: 197–207.

    PubMed  CAS  Google Scholar 

  • Walter, P.B., Knutson, M.D., Paler-Martinez, A., et al. (2002) Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci., 99: 2264–2269.

    PubMed  CAS  Google Scholar 

  • WHO. (1985) Energy and protein requirements: report of a joint FAO/WHO/UNU expert consultation. WHO Tech Rep Ser, n.724, Geneva.

    Google Scholar 

  • Wolf, C. and Tanner, M. (2002) Obesity. West J Med., 176: 23–28.

    PubMed  Google Scholar 

  • Yoshikawa, T.T. (1997) Aging and infectious diseases: past, present, and future. J Infect Dis., 176: 1053–1057.

    PubMed  CAS  Google Scholar 

  • Zimmermann, M. (2001) Micronutrients in health and disease. Georg Thieme Verlag, Stuttgart.

    Google Scholar 

  • Zyczkowska, J., Klich-Raczka, A., Mossakowska, M., Gasowski, J., Wieczorowska-Tobis, K. and Grodzicki, T. (2004) Blood pressure in centenarians in Poland. J Hum Hypertens., 18: 713–716.

    PubMed  CAS  Google Scholar 

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Ferrari, C.K. (2006). Nutritional Deficiency and its Modulation in Old Age. In: Rattan, S.I., Kassem, M. (eds) Prevention and Treatment of Age-related Diseases. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5058-5_16

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