Summary
New tumor entities have been described, which are characteristic for children or young adults. The predominance of TFE translocation carcinomas in the first decades of life demonstrates that renal cell carcinomas in young patients contain genetically and phenotypically distinct tumors with further potential for novel renal cell carcinoma subtypes. The far lower frequency of clear cell carcinomas with VHL alterations in childhood compared to adults suggests that renal cell carcinomas in young patients have a unique genetic background.
Other tumors with apparent predilection for young age groups include clear cell carcinomas in the context of von Hippel-Lindau disease, carcinomas in combination with nephroblastomas, and renal cell carcinomas associated with neuroblastomas.
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References
Eble J, et al. World Health Organization classification of tumours. In: Kleihus P, Sobin L, eds. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon: IARC Press, 2004.
Moch H, et al. Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors. Cancer 2000;89(3):604–614.
Perez-Ordonez B, et al. Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 1997;21(8):871–883.
Kovacs G, et al. The Heidelberg classification of renal cell tumours. J Pathol 1997;183(2):131–133.
Tickoo SK, et al. Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. Am J Surg Pathol 2000;24(9):1247–1256.
Fuzesi L, et al. Cytogenetic analysis of 11 renal oncocytomas: further evidence of structural rearrangements of 11q13 as a characteristic chromosomal anomaly. Cancer Genet Cytogenet 1998;107(1):1–6.
Herbers J, et al. Lack of genetic changes at specific genomic sites separates renal oncocytomas from renal cell carcinomas. J Pathol 1998;184(1):58–62.
Sinke RJ, et al. Fine mapping of the human renal oncocytoma-associated translocation (5;11) (q35;q13) breakpoint. Cancer Genet Cytogenet 1997;96(2):95–101.
Michal M. Benign mixed epithelial and stromal tumor of the kidney. Pathol Res Pract 2000;196(4):275–276.
Michal M, Syrucek M. Benign mixed epithelial and stromal tumor of the kidney. Pathol Res Pract 1998;194:445–448.
Adsay NV, et al. Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol 2000;24(7):958–970.
Moch H, et al. Mixed epithelial and stromal tumor of the kidney. Pathologe, 2004;25:356–361.
Pierson CR, et al. Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma. Hum Pathol 2001;32(5):513–520.
Argani P, et al. Primary renal synovial sarcoma: molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney. Am J Surg Pathol 2000;24(8):1087–1096.
Kim DH, et al. Primary synovial sarcoma of the kidney. Am J Surg Pathol 2000;24(8):1097–1104.
Moch H, et al. Primary renal synovial sarcoma. A new entity in the morphological spectrum of spindle cell tumors. Der Pathologe 2003;24(6):466–472.
Mezzelani A, et al. SYT-SSX fusion transcripts and epithelial differentiation in synovial sarcoma. Diagn Mol Pathol 2000;9(4):234–235.
Fligman I, et al. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. Am J Pathol 1995;147(6):1592–1599.
Furman J, et al. Primary primitive neuroectodermal tumor of the kidney. Am J Clin Pathol 1996;106:339–344.
Rodriguez-Galindo C, et al. Is primitive neuroectodermal tumor of the kidney a distinct entity? Cancer 1997;79(11):2243–2250.
Quezado M, Benjamin DR, Tsokos M. EWS/FLI-1 fusion transcripts in three peripheral primitive neuroectodermal tumors of the kidney. Hum Pathol 1997;28(7):767–771.
Jimenez RE, et al. Primary Ewing’s sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol 2002;26(3):320–327.
Casella R, et al. Metastatic primitive neuroectodermal tumor of the kidney in adults. Eur Urol 2001;39:613–617.
MacLennan GT, Farrow GM, Bostwick DG. Low-grade collecting duct carcinoma of the kidney: report of 13 cases of low-grade mucinous tubulocystic renal carcinoma of possible collecting duct origin. Urology 1997;50(5):679–684.
Srigley J, Eble JN, Grignon DJ. Unusual renal cell carcinoma (RCC) with prominent spindle cell change possibly related to the loop of Henle. Mod Pathol 1999;12:107A.
Srigley J, et al. Phenotypic, molecular and ultrastructural studies of a novel low grade renal epithelial neoplasm possibly related to the loop of Henle. Mod Pathol 2002;15(1):182A.
Rakozy C, et al. Low-grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. Mod Pathol 2002;15(11):1162–1171.
Weber A, Srigley J, Moch H. Mucinous tubular and spindle cell carcinoma of the kidney. A molecular analysis. Pathologe 2003;24(6):453–459.
Argani P, et al. Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol 2001;159(1):179–192.
Renshaw AA, et al. Renal cell carcinomas in children and young adults: increased incidence of papillary architecture and unique subtypes. Am J Surg Pathol 1999;23(7):795–802.
Weterman MA, Wilbrink M, Geurts van Kessel A. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. Proc Natl Acad Sci USA 1996;93(26):15294–15298.
Weterman MA, et al. Molecular cloning of the papillary renal cell carcinoma-associated translocation (X;1)(p11;q21) breakpoint. Cytogenet Cell Genet 1996;75(1):2–6.
Bruder E, et al. Morphologic and molecular characterization of renal cell carcinoma in children and young adults. Am J Surg Pathol 2004;28(9):1117–1132.
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Moch, H. (2005). Oncocytomas and Rare Renal Tumors. In: Waxman, J. (eds) Urological Cancers. Springer, London. https://doi.org/10.1007/1-84628-015-X_25
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DOI: https://doi.org/10.1007/1-84628-015-X_25
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