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Bioresorption and Degradation of Biomaterials

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Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Part of the book series: Advances in Biochemical Engineering Biotechnology ((ABE,volume 126))

Abstract

The human body is a composite structure, completely constructed of biodegradable materials. This allows the cells of the body to remove and replace old or defective tissue with new material. Consequently, artificial resorbable biomaterials have been developed for application in regenerative medicine. We discuss here advantages and disadvantages of these bioresorbable materials for medical applications and give an overview of typically used metals, ceramics and polymers. Methods for the quantification of bioresorption in vitro and in vivo are described. The next challenge will be to better understand the interface between cell and material and to use this knowledge for the design of “intelligent” materials that can instruct the cells to build specific tissue geometries and degrade in the process.

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Acknowledgments

T.W. was supported by a grant from the German Federal Ministry of Education and Science (BMBF, 16SV5057). M.M.M. is consultant to DePuy and Zimmer. Institutional support was received from Ceramtec, Aesculap, DePuy, and Zimmer. No royalties. A.F.S. has in the past 5 years provided consulting services to Biomet, Curasan, Eucro, Heraeus, IPB, and Johnson & Johnson. No royalties.

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Authors and Affiliations

  1. Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München (TUM), Ismaninger Str. 22, 81675, Munich, Germany

    Debarun Das, Ziyang Zhang, Meenakshi Mour, Christina I. Günter, Hans-Günther Machens & Arndt F. Schilling

  2. Biomechanics Section, Hamburg University of Technology (TUHH), Hamburg, Germany

    Thomas Winkler & Michael M. Morlock

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  1. Debarun Das
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  2. Ziyang Zhang
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  3. Thomas Winkler
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Correspondence to Arndt F. Schilling .

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Editors and Affiliations

  1. Department für Biotechnologie, Universität für Bodenkultur, Muthgasse 18, Wien, 1190, Austria

    Cornelia Kasper

  2. , CrossBIT - Center for Biocompatibility, Hannover Medical School, Feodor-Lynen-Str. 31, Hannover, 30625, Germany

    Frank Witte

  3. , Bioprozess- und Biosystemtechnik, Technische Universität Hamburg-Harburg, Denickestrasse 15, Hamburg, 21073, Germany

    Ralf Pörtner

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Das, D. et al. (2011). Bioresorption and Degradation of Biomaterials. In: Kasper, C., Witte, F., Pörtner, R. (eds) Tissue Engineering III: Cell - Surface Interactions for Tissue Culture. Advances in Biochemical Engineering Biotechnology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2011_119

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