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Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface

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Prion Proteins

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 305))

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Abbreviations

EPL:

Expressed protein ligation

NCL:

Native chemical ligation

PrP:

Prion protein

PrPC :

The cellular isoform of prion protein

PrPSc :

The pathogenic or scrapie isoform of prion protein

PTS:

Protein trans splicing

rPrP:

Recombinant prion protein

SPPS:

Solid phase peptide synthesis

TEV:

Tobacco etch virus

TSE:

Transmissible spongiform encephalopathy

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Acknowledgement

Our work was supported by Max Planck Society. We would like to thank Frederieke Itzen, Claudia Pieczka, and Marc Dittmann for preparation of the figures and Florian Seebeck for critically reading the manuscript.

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  1. Max Planck Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, 44227, Dortmund, Germany

    Ralf Seidel & Martin Engelhard

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  2. Martin Engelhard
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Correspondence to Martin Engelhard .

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  1. Adolf-Butenandt-Institute, Abt. Biochemie, Universität München, Schillerstr. 44, München, 80336, Germany

    Jörg Tatzelt

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Seidel, R., Engelhard, M. (2011). Chemical Biology of Prion Protein: Tools to Bridge the In Vitro/Vivo Interface. In: Tatzelt, J. (eds) Prion Proteins. Topics in Current Chemistry, vol 305. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_201

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