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Transition Metal-Catalyzed C–C Bond Activation of Four-Membered Cyclic Ketones

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C-C Bond Activation

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 346))

Abstract

With the advent of new synthetic methodologies, carbon–carbon bond (C–C) activation strategies have uncovered not only new fundamental reactivity but also the potential for use as a highly efficient synthetic protocol. This chapter specifically discusses the use of four-membered ketone-based starting materials for C–C activation initiated transformations using a variety of transition metals. The two major modes of activation, oxidative addition and β-C elimination, are presented as each pathway shows different mechanistic details and the ability to effect several types of reactions. Applications to the synthesis of complex molecules are presented and perspectives on future applications are considered.

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Notes

  1. 1.

    Murakami suggested an oxidative addition mechanism in [35].

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Acknowledgement

We thank UT Austin and CPRIT for a startup fund, NIGMS (R01GM109054-01) and the Welch Foundation (F 1781) for research grants. We thank Prof. Yoshiaki Nakao for proofreading this review chapter and thoughtful suggestions, and we also thank Dr. Jotham W. Coe for his generous efforts in editing the manuscript.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, TX, 78712-0165, USA

    Tao Xu, Alpay Dermenci & Guangbin Dong

  2. Pfizer Inc., Worldwide Medicinal Chemistry, 445 Eastern Point Road, Groton, CT, 06340, USA

    Alpay Dermenci

Authors
  1. Tao Xu
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  2. Alpay Dermenci
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  3. Guangbin Dong
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Correspondence to Guangbin Dong .

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Editors and Affiliations

  1. The University of Texas at Austin Department of Chemistry & Biochemistry, Austin, USA

    Guangbin Dong

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Xu, T., Dermenci, A., Dong, G. (2014). Transition Metal-Catalyzed C–C Bond Activation of Four-Membered Cyclic Ketones. In: Dong, G. (eds) C-C Bond Activation. Topics in Current Chemistry, vol 346. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2014_545

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