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Aptamer: Biology to Applications

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Nucleic Acid Drugs

Part of the book series: Advances in Polymer Science ((POLYMER,volume 249))

Abstract

Aptamers are short single-stranded nucleic acid sequences that are selected in vitro from large oligonucleotide libraries on the basis of their high affinity to a target molecule. Hence, aptamers can be thought of as a nucleic acid analog to antibodies. However, the potential of aptamers arises from interesting characteristics that are distinct from, or in some cases superior to, those of antibodies from several viewpoints. This review summarizes the recent achievements in aptamer programs developed in our laboratory against basic as well as therapeutic protein targets. Through these studies, we became aware of RNA’s remarkable conformational plasticity, which the literature has not shed light on even though this is evidently a crucial feature for the strong specificity and affinity of RNA aptamers.

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Acknowledgments

I kindly thank all coworkers and collaborators in my laboratory, Ribomic Inc., Sosho Inc., Chiba Institute of Technology, and Osaka University; and C. Crist for his help in editing the manuscript. This work was supported in part by Core Research for Evolution Science and Technology (CREST) grant from the Japan Science and Technology Agency, and research grants from The Ministry of Education, Sports, Culture, Science and Technology of Japan (MEXT) and from Ministry of Health, Labour and Welfare.

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Authors and Affiliations

  1. Division of Molecular Biology, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Yoshikazu Nakamura

  2. CREST JST, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Yoshikazu Nakamura

  3. RIBOMIC Inc, 3-16-13 Shirokanedai, Minato-ku, Tokyo, 108-0071, Japan

    Yoshikazu Nakamura

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  1. Yoshikazu Nakamura
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Correspondence to Yoshikazu Nakamura .

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Editors and Affiliations

  1. Dept. Biomolecular Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto, 606-8585, Japan

    Akira Murakami

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Nakamura, Y. (2011). Aptamer: Biology to Applications. In: Murakami, A. (eds) Nucleic Acid Drugs. Advances in Polymer Science, vol 249. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2011_128

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