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Biodegradable Polymers for Potential Delivery Systems for Therapeutics

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Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology

Part of the book series: Advances in Polymer Science ((POLYMER,volume 254))

Abstract

Biodegradable polymers are being extensively used with great interest in areas of nanobiotechnology such as drug delivery, diagnostics, and other applications for clinical and biomedical research covering cardiovascular diseases, diabetes, osteogenesis, cancer, and tissue engineering. Various biodegradable polymers such as poly(lactic acid), poly(lactic-co-glycolic acid), poly (ε-caprolactone), chitosan, gelatin, and poly(alkyl cyanoacrylates) have been extensively utilized as polymeric materials and devices for targeted cellular and tissue-specific clinical applications to achieve maximal therapeutic efficacy with minimal or no side effects. Recently, polymeric nanoparticles have revolutionized the area of nanobiotechnology by creating new opportunities for advancing medical science and disease treatment. Polymeric nanoparticles have the potential to act as a carrier of drugs and active constituents to targeted sites, protecting them from the environment and controlling their release rates, thereby enhancing their biological activity and decreasing the adverse side effects. This article compiles updated information regarding various biodegradable polymers, methods of preparation of biodegradable polymeric nanoparticles, and their application in therapeutic and diagnostic strategies for various diseases. This article will support research scientists and clinical physicians who are interested in the development and application of biodegradable polymeric nanoparticles as potential delivery systems for therapeutics.

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Acknowledgements

The authors are thankful to the University Grants Commission (UGC), New Delhi, India, for providing research facilities and financial support to Dr. S.K. Pandey as UGC-Kothari postdoctoral fellow (No.F.4-2/2006(BSR)/13-449/2011) in the Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi, India. The authors also acknowledge the receipt of research funding from Department of Biotechnology (DBT), New Delhi, Ministry of Science and Technology, Government of India (Project No. BT/PR-6929/BCE/08/433/2005).

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  1. Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India

    Sanjeev K. Pandey & Chandana Haldar

  2. School of Materials Science and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India

    Dinesh K. Patel & Pralay Maiti

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  1. Sanjeev K. Pandey
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  2. Chandana Haldar
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  3. Dinesh K. Patel
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  4. Pralay Maiti
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Correspondence to Pralay Maiti .

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  1. Department of Chemistry, MN National Institute of Technology, Allahabad, Uttar Pradesh, India

    P.K. Dutta

  2. Department of  Applied Sciences & Humanities, Institute of Engineering & Technology, ITM University, Raipur, Chhaattisgarh, India

    Joydeep Dutta

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Pandey, S.K., Haldar, C., Patel, D.K., Maiti, P. (2013). Biodegradable Polymers for Potential Delivery Systems for Therapeutics. In: Dutta, P., Dutta, J. (eds) Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology. Advances in Polymer Science, vol 254. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2012_198

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