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Pulmonary MRI in Clinical Trials

  • Chapter
MRI of the Lung

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Until very recently, pulmonary MRI has played a limited clinical role for patients with chronic lung diseases such as COPD and asthma. The reasons for this are numerous and complex; yet, because of a concerted effort of a number of key research sites, pulmonary MRI endpoints are increasingly being used as research tools and biomarkers in clinical trials. A number of previous landmark studies focused on the development and validation of biomarkers to provide a better understanding of structural and functional information. These biomarkers are now being applied in emerging cohort studies to forge a better understanding of lung disease in cross-sectional and longitudinal evaluations and in the evaluation of localized treatment and regional treatment responses. Pulmonary MRI biomarker use has certainly been increasing, but gaps remain between the research bench and clinical workflows to patient care. Advancing pulmonary MRI toward clinical implementation will require the concerted, globally collaborative development and validation of clinically relevant biomarkers in multinational cohort studies and clinical trials.

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References

  • Agusti A, Calverley PM, Celli B, Coxson HO, Edwards LD, Lomas DA, MacNee W, Miller BE, Rennard S, Silverman EK, Tal-Singer R, Wouters E, Yates JC, Vestbo J, Evaluation of CLtIPSEi (2010) Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 11:122. doi:10.1186/1465-9921-11-122

    Article  PubMed  PubMed Central  Google Scholar 

  • Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS, Wishnia A (1994) Biological magnetic-resonance-imaging using laser polarized Xe-129. Nature 370(6486):199–201. doi:10.1038/370199a0

    Article  CAS  PubMed  Google Scholar 

  • Altes TA, Powers PL, Knight-Scott J, Rakes G, Platts-Mills TA, de Lange EE, Alford BA, Mugler JP 3rd, Brookeman JR (2001) Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings. J Magn Reson Imaging 13(3):378–384

    Article  CAS  PubMed  Google Scholar 

  • Bannier E, Cieslar K, Mosbah K, Aubert F, Duboeuf F, Salhi Z, Gaillard S, Berthezene Y, Cremillieux Y, Reix P (2010) Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function. Radiology 255(1):225–232. doi:10.1148/radiol.09090039

    Article  PubMed  Google Scholar 

  • Bauman G, Puderbach M, Deimling M, Jellus V, Chefd'hotel C, Dinkel J, Hintze C, Kauczor HU, Schad LR (2009) Non-contrast-enhanced perfusion and ventilation assessment of the human lung by means of fourier decomposition in proton MRI. Magn Reson Med 62(3):656–664

    Article  PubMed  Google Scholar 

  • Bauman G, Puderbach M, Heimann T, Kopp-Schneider A, Fritzsching E, Mall MA, Eichinger M (2013a) Validation of Fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients. Eur J Radiol 82(12):2371–2377. doi:10.1016/j.ejrad.2013.08.018

    Article  PubMed  Google Scholar 

  • Bauman G, Scholz A, Rivoire J, Terekhov M, Friedrich J, de Oliveira A, Semmler W, Schreiber LM, Puderbach M (2013b) Lung ventilation-and perfusion-weighted Fourier decomposition magnetic resonance imaging: in vivo validation with hyperpolarized 3He and dynamic contrast-enhanced MRI. Magn Reson Med 69(1):229–237

    Article  CAS  PubMed  Google Scholar 

  • Bergin CJ, Pauly JM, Macovski A (1991) Lung parenchyma: projection reconstruction MR imaging. Radiology 179(3):777–781. doi:10.1148/radiology.179.3.2027991

    Article  CAS  PubMed  Google Scholar 

  • Bergin CJ, Glover GM, Pauly J (1993) Magnetic resonance imaging of lung parenchyma. J Thorac Imaging 8(1):12–17

    Article  CAS  PubMed  Google Scholar 

  • Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, Greenland P, Jacob DR Jr, Kronmal R, Liu K, Nelson JC, O'Leary D, Saad MF, Shea S, Szklo M, Tracy RP (2002) Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol 156(9):871–881

    Article  PubMed  Google Scholar 

  • Bourbeau J, Tan WC, Benedetti A, Aaron SD, Chapman KR, Coxson HO, Cowie R, Fitzgerald M, Goldstein R, Hernandez P, Leipsic J, Maltais F, Marciniuk D, O'Donnell D, Sin DD, Cancold Study G (2014) Canadian Cohort Obstructive Lung Disease (CanCOLD): fulfilling the need for longitudinal observational studies in COPD. COPD 11(2):125–132. doi:10.3109/15412555.2012.665520

    Article  PubMed  Google Scholar 

  • Burris NS, Johnson KM, Larson PE, Hope MD, Nagle SK, Behr SC, Hope TA (2016) Detection of Small Pulmonary Nodules with Ultrashort Echo Time Sequences in Oncology Patients by Using a PET/MR System. Radiology 278(1):239–246. doi:10.1148/radiol.2015150489

    Article  PubMed  Google Scholar 

  • Capaldi DP, Sheikh K, Guo F, Svenningsen S, Etemad-Rezai R, Coxson HO, Leipsic JA, McCormack DG, Parraga G (2015) Free-breathing pulmonary 1H and Hyperpolarized 3He MRI: comparison in COPD and bronchiectasis. Acad Radiol 22(3):320–329. doi:10.1016/j.acra.2014.10.003

    Article  PubMed  Google Scholar 

  • Capaldi DP, Zha N, Guo F, Pike D, McCormack DG, Kirby M, Parraga G (2016) Pulmonary Imaging Biomarkers of Gas Trapping and Emphysema in COPD: (3)He MR Imaging and CT Parametric Response Maps. Radiology 279(2):597–608. doi:10.1148/radiol.2015151484

    Article  PubMed  Google Scholar 

  • Costella S, Kirby M, Maksym GN, McCormack DG, Paterson NA, Parraga G (2012) Regional pulmonary response to a methacholine challenge using hyperpolarized (3)He magnetic resonance imaging. Respirology (Carlton, Vic) 17(8):1237–1246. doi:10.1111/j.1440-1843.2012.02250.x

    Article  Google Scholar 

  • Couch MJ, Ball IK, Li T, Fox MS, Ouriadov AV, Biman B, Albert MS (2014) Inert fluorinated gas MRI: a new pulmonary imaging modality. NMR Biomed 27(12):1525–1534. doi:10.1002/nbm.3165

    Article  CAS  PubMed  Google Scholar 

  • Couper D, LaVange LM, Han M, Barr RG, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S, Group SR (2014) Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 69(5):491–494. doi:10.1136/thoraxjnl-2013-203897

    Article  PubMed  Google Scholar 

  • de Lange EE, Altes TA, Patrie JT, Gaare JD, Knake JJ, Mugler JP 3rd, Platts-Mills TA (2006) Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 130(4):1055–1062. doi:10.1378/chest.130.4.1055

    Article  PubMed  Google Scholar 

  • de Lange EE, Altes TA, Patrie JT, Parmar J, Brookeman JR, Mugler JP, Platts-Mills TAE (2007) The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging. J Allergy Clin Immunol 119(5):1072–1078. doi:10.1016/j.jaci.2006.12.659

    Article  PubMed  Google Scholar 

  • de Lange EE, Altes TA, Patrie JT, Battiston JJ, Juersivich AP, Mugler JP 3rd, Platts-Mills TA (2009) Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 250(2):567–575. doi:10.1148/radiol.2502080188

    Article  PubMed  Google Scholar 

  • Deninger AJ, Eberle B, Ebert M, Grossmann T, Heil W, Kauczor H, Lauer L, Markstaller K, Otten E, Schmiedeskamp J, Schreiber W, Surkau R, Thelen M, Weiler N (1999) Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by (3)He MRI. J Magn Reson 141(2):207–216. doi:10.1006/jmre.1999.1902

    Article  CAS  PubMed  Google Scholar 

  • Diaz S, Casselbrant I, Piitulainen E, Magnusson P, Peterson B, Wollmer P, Leander P, Ekberg O, Akeson P (2009) Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references. Eur J Radiol 71(2):257–263. doi:10.1016/j.ejrad.2008.04.013

    Article  PubMed  Google Scholar 

  • Donnelly LF, MacFall JR, McAdams HP, Majure JM, Smith J, Frush DP, Bogonad P, Charles HC, Ravin CE (1999) Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung–preliminary observations. Radiology 212(3):885–889. doi:10.1148/radiology.212.3.r99se20885

    Article  CAS  PubMed  Google Scholar 

  • Dournes G, Menut F, Macey J, Fayon M, Chateil JF, Salel M, Corneloup O, Montaudon M, Berger P, Laurent F (2016) Lung morphology assessment of cystic fibrosis using MRI with ultra-short echo time at submillimeter spatial resolution. Eur Radiol. doi:10.1007/s00330-016-4218-5

    Article  PubMed  Google Scholar 

  • Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA (2006) Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A 103(48):18278–18283. doi:10.1073/pnas.0608458103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Driehuys B, Martinez-Jimenez S, Cleveland ZI, Metz GM, Beaver DM, Nouls JC, Kaushik SS, Firszt R, Willis C, Kelly KT, Wolber J, Kraft M, McAdams HP (2012) Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology 262(1):279–289. doi:10.1148/radiol.11102172

    Article  PubMed  PubMed Central  Google Scholar 

  • Ebert M, Grossmann T, Heil W, Otten WE, Surkau R, Leduc M, Bachert P, Knopp MV, Schad LR, Thelen M (1996) Nuclear magnetic resonance imaging with hyperpolarised helium-3. Lancet 347(9011):1297–1299

    Article  CAS  PubMed  Google Scholar 

  • Edelman RR, Hatabu H, Tadamura E, Li W, Prasad PV (1996) Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat Med 2(11):1236–1239

    Article  CAS  PubMed  Google Scholar 

  • Eichinger M, Optazaite DE, Kopp-Schneider A, Hintze C, Biederer J, Niemann A, Mall MA, Wielputz MO, Kauczor HU, Puderbach M (2012) Morphologic and functional scoring of cystic fibrosis lung disease using MRI. Eur J Radiol 81(6):1321–1329. doi:10.1016/j.ejrad.2011.02.045

    Article  PubMed  Google Scholar 

  • Fain SB, Altes TA, Panth SR, Evans MD, Waters B, Mugler JP 3rd, Korosec FR, Grist TM, Silverman M, Salerno M, Owers-Bradley J (2005) Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI. Acad Radiol 12(11):1385–1393. doi:10.1016/j.acra.2005.08.005

    Article  PubMed  Google Scholar 

  • Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour NN, Busse WW, Kuhlman JE (2008) Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI. Acad Radiol 15(6):753–762. doi:10.1016/j.acra.2007.10.019

    Article  PubMed  PubMed Central  Google Scholar 

  • Fain SB, Peterson ET, Sorkness RL, Wenzel S, Castro M, Busse WW (2009) Severe asthma research program – phenotyping and quantification of severe asthma. Imaging Decis MRI 13(1):24–27. doi:10.1111/j.1617-0830.2009.01124.x

    Article  Google Scholar 

  • Gupta S, Siddiqui S, Haldar P, Raj JV, Entwisle JJ, Wardlaw AJ, Bradding P, Pavord ID, Green RH, Brightling CE (2009) Qualitative analysis of high-resolution CT scans in severe asthma. Chest 136(6):1521–1528. doi:10.1378/chest.09-0174

    Article  PubMed  PubMed Central  Google Scholar 

  • Hamedani H, Kadlecek SJ, Ishii M, Xin Y, Emami K, Han B, Shaghaghi H, Gopstein D, Cereda M, Gefter WB, Rossman MD, Rizi RR (2015) Alterations of regional alveolar oxygen tension in asymptomatic current smokers: assessment with hyperpolarized (3)He MR imaging. Radiology 274(2):585–596. doi:10.1148/radiol.14132809

    Article  PubMed  Google Scholar 

  • Hatabu H, Gaa J, Kim D, Li W, Prasad PV, Edelman RR (1996) Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH. Magn Reson MedOffJ Soc Magn Reson MedSocMagn ResonMed 36(4):503–508

    Article  CAS  Google Scholar 

  • Hogg JC, Macklem PT, Thurlbeck WM (1968) Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 278(25):1355–1360. doi:10.1056/NEJM196806202782501

    Article  CAS  PubMed  Google Scholar 

  • Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350(26):2645–2653. doi:10.1056/NEJMoa032158

    Article  CAS  PubMed  Google Scholar 

  • Hoover DA, Capaldi DP, Sheikh K, Palma DA, Rodrigues GB, Dar AR, Yu E, Dingle B, Landis M, Kocha W, Sanatani M, Vincent M, Younus J, Kuruvilla S, Gaede S, Parraga G, Yaremko BP (2014) Functional lung avoidance for individualized radiotherapy (FLAIR): study protocol for a randomized, double-blind clinical trial. BMC Cancer 14:934. doi:10.1186/1471-2407-14-934

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ireland RH, Din OS, Swinscoe JA, Woodhouse N, van Beek EJ, Wild JM, Hatton MQ (2010) Detection of radiation-induced lung injury in non-small cell lung cancer patients using hyperpolarized helium-3 magnetic resonance imaging. Radiother OncolJ Eur Soc Ther RadiolOncol 97(2):244–248. doi:10.1016/j.radonc.2010.07.013

    Article  Google Scholar 

  • Ishii M, Hamedani H, Clapp JT, Kadlecek SJ, Xin Y, Gefter WB, Rossman MD, Rizi RR (2015) Oxygen-weighted Hyperpolarized (3)He MR imaging: ashort-term reproducibility study in human subjects. Radiology 277(1):247–258. doi:10.1148/radiol.2015142038

    Article  PubMed  Google Scholar 

  • Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague WG, Wenzel SE, Busse WW, Program NSAR (2012) Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med 185(4):356–362. doi:10.1164/rccm.201107-1317PP

    Article  PubMed  PubMed Central  Google Scholar 

  • Jobst BJ, Wielputz MO, Triphan SM, Anjorin A, Ley-Zaporozhan J, Kauczor HU, Biederer J, Ley S, Sedlaczek O (2015) Morpho-functional 1H-MRI of the lung in COPD: short-term test-retest reliability. PLoS One 10(9):e0137282. doi:10.1371/journal.pone.0137282

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jones PW (2009) Health status and the spiral of decline. COPD 6(1):59–63. doi:10.1080/15412550802587943

    Article  PubMed  Google Scholar 

  • Karch A, Vogelmeier C, Welte T, Bals R, Kauczor HU, Biederer J, Heinrich J, Schulz H, Glaser S, Holle R, Watz H, Korn S, Adaskina N, Biertz F, Vogel C, Vestbo J, Wouters EF, Rabe KF, Sohler S, Koch A, Jorres RA, Group CS (2016) The German COPD cohort COSYCONET: aims, methods and descriptive analysis of the study population at baseline. Respir Med 114:27–37. doi:10.1016/j.rmed.2016.03.008

    Article  PubMed  Google Scholar 

  • Kauczor HU, Hofmann D, Kreitner KF, Nilgens H, Surkau R, Heil W, Potthast A, Knopp MV, Otten EW, Thelen M (1996) Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging. Radiology 201(2):564–568

    Article  CAS  PubMed  Google Scholar 

  • Khakban A, Sin DD, FitzGerald JM, Ng R, Zafari Z, McManus B, Hollander Z, Marra CA, Sadatsafavi M (2015) Ten-year trends in direct costs of COPD: apopulation-based study. Chest 148(3):640–646. doi:10.1378/chest.15-0721

    Article  PubMed  Google Scholar 

  • Kirby M, Mathew L, Wheatley A, Santyr GE, McCormack DG, Parraga G (2010a) Chronic obstructive pulmonary disease: longitudinal hyperpolarized (3)He MR imaging. Radiology 256(1):280–289. doi:10.1148/radiol.10091937

    Article  PubMed  Google Scholar 

  • KirbyM, WheatleyA, McCormackDG, ParragaG (2010b) Development and application of methods to quantify spatial and temporal hyperpolarized 3He MRI ventilation dynamics: preliminary results in chronic obstructive pulmonary disease. In: SPIE Medical Imaging. International Society for Optics and Photonics, pp 762605–762605-762609

    Google Scholar 

  • Kirby M, Mathew L, Heydarian M, Etemad-Rezai R, McCormack DG, Parraga G (2011a) Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized (3)He MR imaging. Radiology 261(1):283–292. doi:10.1148/radiol.11110403

    Article  PubMed  Google Scholar 

  • Kirby M, Svenningsen S, Ahmed H, Wheatley A, Etemad-Rezai R, Paterson NA, Parraga G (2011b) Quantitative evaluation of hyperpolarized helium-3 magnetic resonance imaging of lung function variability in cystic fibrosis. Acad Radiol 18(8):1006–1013. doi:10.1016/j.acra.2011.03.005

    Article  PubMed  Google Scholar 

  • Kirby M, Svenningsen S, Owrangi A, Wheatley A, Farag A, Ouriadov A, Santyr GE, Etemad-Rezai R, Coxson HO, McCormack DG, Parraga G (2012) Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease. Radiology 265(2):600–610. doi:10.1148/radiol.12120485

    Article  PubMed  Google Scholar 

  • Kirby M, Svenningsen S, Kanhere N, Owrangi A, Wheatley A, Coxson HO, Santyr GE, Paterson NA, McCormack DG, Parraga G (2013) Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. J Appl Physiol (Bethesda, Md : 1985) 114(6):707–715. doi:10.1152/japplphysiol.01206.2012

    Article  CAS  Google Scholar 

  • Kirby M, Ouriadov A, Svenningsen S, Owrangi A, Wheatley A, Etemad-Rezai R, Santyr GE, McCormack DG, Parraga G (2014a) Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers. Physiol Rep 2(7). doi:10.14814/phy2.12068

    Article  PubMed  PubMed Central  Google Scholar 

  • Kirby M, Pike D, Coxson HO, McCormack DG, Parraga G (2014b) Hyperpolarized (3)He ventilation defects used to predict pulmonary exacerbations in mild to moderate chronic obstructive pulmonary disease. Radiology 273(3):887–896. doi:10.1148/radiol.14140161

    Article  PubMed  Google Scholar 

  • Kirby M, Pike D, McCormack DG, Lam S, Sin DD, Coxson HO, Parraga G (2014c) Longitudinal computed tomography and magnetic resonance imaging of COPD: Thoracic Imaging Network of Canada (TINCan) study objectives. Chron Obstruct Pulmon Dis J COPD Found 1(2):200–211

    Article  Google Scholar 

  • Kirby M, Pike D, Sin DD, Coxson HO, McCormack DG, Parraga G (2015) COPD: do imaging measurements of emphysema and airway disease explain symptoms and exercise capacity? Radiology 277(3):872–880. doi:10.1148/radiol.2015150037

    Article  PubMed  Google Scholar 

  • Kruger SJ, Niles DJ, Dardzinski B, Harman A, Jarjour NN, Ruddy M, Nagle SK, Francois CJ, Sorkness RL, Burton RM, Munoz del Rio A, Fain SB (2014) Hyperpolarized Helium-3 MRI of exercise-induced bronchoconstriction during challenge and therapy. J MagnReson Imaging 39(5):1230–1237. doi:10.1002/jmri.24272

    Article  Google Scholar 

  • Lederlin M, Bauman G, Eichinger M, Dinkel J, Brault M, Biederer J, Puderbach M (2013) Functional MRI using Fourier decomposition of lung signal: reproducibility of ventilation-and perfusion-weighted imaging in healthy volunteers. Eur J Radiol 82(6):1015–1022

    Article  PubMed  Google Scholar 

  • Lutey BA, Lefrak SS, Woods JC, Tanoli T, Quirk JD, Bashir A, Yablonskiy DA, Conradi MS, Bartel ST, Pilgram TK, Cooper JD, Gierada DS (2008) Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects. Radiology 248(2):655–661. doi:10.1148/radiol.2482071838

    Article  PubMed  PubMed Central  Google Scholar 

  • Ma W, Sheikh K, Svenningsen S, Pike D, Guo F, Etemad-Rezai R, Leipsic J, Coxson HO, McCormack DG, Parraga G (2015) Ultra-short echo-time pulmonary MRI: evaluation and reproducibility in COPD subjects with and without bronchiectasis. JMagn Reson Imaging 41(5):1465–1474. doi:10.1002/jmri.24680

    Article  Google Scholar 

  • Mathew L, Evans A, Ouriadov A, Etemad-Rezai R, Fogel R, Santyr G, McCormack DG, Parraga G (2008) Hyperpolarized 3He magnetic resonance imaging of chronic obstructive pulmonary disease: reproducibility at 3.0 tesla. Acad Radiol 15(10):1298–1311. doi:10.1016/j.acra.2008.04.019

    Article  PubMed  Google Scholar 

  • Mathew L, Gaede S, Wheatley A, Etemad-Rezai R, Rodrigues GB, Parraga G (2010) Detection of longitudinal lung structural and functional changes after diagnosis of radiation-induced lung injury using hyperpolarized 3He magnetic resonance imaging. Med Phys 37(1):22–31. doi:10.1118/1.3263616

    Article  CAS  PubMed  Google Scholar 

  • Mathew L, Kirby M, Etemad-Rezai R, Wheatley A, McCormack DG, Parraga G (2011) Hyperpolarized (3)He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease. Eur J Radiol 79(1):140–146. doi:10.1016/j.ejrad.2009.10.028

    Article  PubMed  Google Scholar 

  • Mathew L, Kirby M, Farquhar D, Licskai C, Santyr G, Etemad-Rezai R, Parraga G, McCormack DG (2012a) Hyperpolarized 3He functional magnetic resonance imaging of bronchoscopic airway bypass in chronic obstructive pulmonary disease. Can RespirJ J Can Thorac Soc 19(1):41–43

    Google Scholar 

  • Mathew L, Vandyk J, Etemad-Rezai R, Rodrigues G, Parraga G (2012b) Hyperpolarized (3)He pulmonary functional magnetic resonance imaging prior to radiation therapy. Med Phys 39(7):4284–4290. doi:10.1118/1.4729713

    Article  CAS  PubMed  Google Scholar 

  • Mathew L, Wheatley A, Castillo R, Castillo E, Rodrigues G, Guerrero T, Parraga G (2012c) Hyperpolarized (3)He magnetic resonance imaging: comparison with four-dimensional x-ray computed tomography imaging in lung cancer. Acad Radiol 19(12):1546–1553. doi:10.1016/j.acra.2012.08.007

    Article  PubMed  Google Scholar 

  • McMahon CJ, Dodd JD, Hill C, Woodhouse N, Wild JM, Fichele S, Gallagher CG, Skehan SJ, van Beek EJ, Masterson JB (2006) Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry. Eur Radiol 16(11):2483–2490. doi:10.1007/s00330-006-0311-5

    Article  PubMed  Google Scholar 

  • Meaney JF, Weg JG, Chenevert TL, Stafford-Johnson D, Hamilton BH, Prince MR (1997) Diagnosis of pulmonary embolism with magnetic resonance angiography. N Engl J Med 336(20):1422–1427. doi:10.1056/NEJM199705153362004

    Article  CAS  PubMed  Google Scholar 

  • Mentore K, Froh DK, de Lange EE, Brookeman JR, Paget-Brown AO, Altes TA (2005) Hyperpolarized HHe 3 MRI of the lung in cystic fibrosis: assessment at baseline and after bronchodilator and airway clearance treatment1. Acad Radiol 12(11):1423–1429

    Article  PubMed  Google Scholar 

  • Morbach AE, Gast KK, Schmiedeskamp J, Dahmen A, Herweling A, Heussel CP, Kauczor HU, Schreiber WG (2005) Diffusion-weighted MRI of the lung with hyperpolarized helium-3: a study of reproducibility. J Magn Reson Imaging 21(6):765–774. doi:10.1002/jmri.20300

    Article  PubMed  Google Scholar 

  • Mugler III J(1998) Optimization of gradient-echo sequences for hyperpolarized noble gas MRI. In: Proceedings of the 6th annual meeting of ISMRM, Sydney, p 1904

    Google Scholar 

  • Mugler JP 3rd, Driehuys B, Brookeman JR, Cates GD, Berr SS, Bryant RG, Daniel TM, de Lange EE, Downs JH 3rd, Erickson CJ, Happer W, Hinton DP, Kassel NF, Maier T, Phillips CD, Saam BT, Sauer KL, Wagshul ME (1997) MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results. Magn Reson Med 37(6):809–815

    Article  PubMed  Google Scholar 

  • Mugler JP 3rd, Altes TA, Ruset IC, Dregely IM, Mata JF, Miller GW, Ketel S, Ketel J, Hersman FW, Ruppert K (2010) Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc Natl Acad Sci U S A 107(50):21707–21712. doi:10.1073/pnas.1011912107

    Article  PubMed  PubMed Central  Google Scholar 

  • OECD OfEC-oaD (2007) Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) Census. Benchmark Report: IMV, Limited, Medical Information Division

    Google Scholar 

  • Parraga G, Ouriadov A, Evans A, McKay S, Lam WW, Fenster A, Etemad-Rezai R, McCormack D, Santyr G (2007) Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol 42(6):384–391. doi:10.1097/01.rli.0000262571.81771.66

    Article  PubMed  Google Scholar 

  • Parraga G, Mathew L, Etemad-Rezai R, McCormack DG, Santyr GE (2008) Hyperpolarized 3He magnetic resonance imaging of ventilation defects in healthy elderly volunteers: initial findings at 3.0 Tesla. Acad Radiol 15(6):776–785. doi:10.1016/j.acra.2008.03.003

    Article  PubMed  Google Scholar 

  • Paulin GA, Svenningsen S, Jobse BN, Mohan S, Kirby M, Lewis JF, Parraga G (2015) Differences in hyperpolarized (3) He ventilation imaging after 4 years in adults with cystic fibrosis. J Magn Reson Imaging 41(6):1701–1707. doi:10.1002/jmri.24744

    Article  PubMed  Google Scholar 

  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, Committee GS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 163(5):1256–1276. doi:10.1164/ajrccm.163.5.2101039

    Article  CAS  PubMed  Google Scholar 

  • Puderbach M, Eichinger M, Gahr J, Ley S, Tuengerthal S, Schmahl A, Fink C, Plathow C, Wiebel M, Muller FM, Kauczor HU (2007) Proton MRI appearance of cystic fibrosis: comparison to CT. Eur Radiol 17(3):716–724. doi:10.1007/s00330-006-0373-4

    Article  PubMed  Google Scholar 

  • Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD (2010) Genetic epidemiology of COPD (COPDGene) study design. COPD 7(1):32–43. doi:10.3109/15412550903499522

    Article  PubMed  Google Scholar 

  • Samee S, Altes T, Powers P, de Lange EE, Knight-Scott J, Rakes G, Mugler JP 3rd, Ciambotti JM, Alford BA, Brookeman JR, Platts-Mills TA (2003) Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge. J Allergy Clin Immunol 111(6):1205–1211

    Article  CAS  PubMed  Google Scholar 

  • Schonfeld C, Cebotari S, Voskrebenzev A, Gutberlet M, Hinrichs J, Renne J, Hoeper MM, Olsson KM, Welte T, Wacker F, Vogel-Claussen J (2014) Performance of perfusion-weighted Fourier decomposition MRI for detection of chronic pulmonary emboli. J Magn Reson Imaging. doi:10.1002/jmri.24764

    Article  PubMed  Google Scholar 

  • Sheikh K, Capaldi DP, Hoover DA, Palma DA, Yaremko BP, Parraga G (2015) Magnetic resonance imaging biomarkers of chronic obstructive pulmonary disease prior to radiation therapy for non-small cell lung cancer. Eur J Radiol Open 2:81–89. doi:10.1016/j.ejro.2015.05.003

    Article  PubMed  PubMed Central  Google Scholar 

  • Shukla Y, Wheatley A, Kirby M, Svenningsen S, Farag A, Santyr GE, Paterson NA, McCormack DG, Parraga G (2012) Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy volunteers and subjects with pulmonary disease. Acad Radiol 19(8):941–951. doi:10.1016/j.acra.2012.03.018

    Article  PubMed  Google Scholar 

  • SoherBJ, AinslieM, MacFallJ, HashoianR, CharlesHC (2010) Lung imaging in humans at 3 T using perfluorinated gases as MR contrast agents [abstr]. In: Proceedings of the Eighteenth Meeting of the International Society for Magnetic Resonance in Medicine Berkeley, Calif: International Society for Magnetic Resonance in Medicine:3389

    Google Scholar 

  • Sommer G, Bauman G, Koenigkam-Santos M, Draenkow C, Heussel CP, Kauczor HU, Schlemmer HP, Puderbach M (2013) Non-contrast-enhanced preoperative assessment of lung perfusion in patients with non-small-cell lung cancer using Fourier decomposition magnetic resonance imaging. Eur J Radiol 82(12):E879–E887. doi:10.1016/j.ejrad.2013.06.030

    Article  PubMed  Google Scholar 

  • Svenningsen S, Kirby M, Starr D, Leary D, Wheatley A, Maksym GN, McCormack DG, Parraga G (2013) Hyperpolarized (3) He and (129) Xe MRI: differences in asthma before bronchodilation. J Magn Reson Imaging 38(6):1521–1530. doi:10.1002/jmri.24111

    Article  PubMed  Google Scholar 

  • Svenningsen S, Kirby M, Starr D, Coxson HO, Paterson NA, McCormack DG, Parraga G (2014a) What are ventilation defects in asthma? Thorax 69(1):63–71. doi:10.1136/thoraxjnl-2013-203711

    Article  PubMed  Google Scholar 

  • Svenningsen S, Paulin G, Wheatley A, Pike D, Suggett J, McCormack D, Parraga G (2014b) Oscillating positive expiratory pressure (oPEP) therapy in chronic obstructive pulmonary disease and bronchiectasis. Eur Respir J 44(Suppl 58):P3679

    Google Scholar 

  • Svenningsen S, Nair P, Guo F, McCormack DG, Parraga G (2016a) Is ventilation heterogeneity related to asthma control? Eur Respir J. doi:10.1183/13993003.00393-2016

    Article  PubMed  Google Scholar 

  • Svenningsen S, Paulin GA, Sheikh K, Guo F, Hasany A, Kirby M, Etemad Rezai R, McCormack DG, Parraga G (2016b) Oscillatory positive expiratory pressure in chronic obstructive pulmonary disease. COPD 13(1):66–74. doi:10.3109/15412555.2015.1043523

    Article  PubMed  Google Scholar 

  • Teague WG, Tustison NJ, Altes TA (2014) Ventilation heterogeneity in asthma. J Asthma 51(7):677–684. doi:10.3109/02770903.2014.914535

    Article  PubMed  Google Scholar 

  • Tgavalekos NT, Musch G, Harris RS, Melo MFV, Winkler T, Schroeder T, Callahan R, Lutchen KR, Venegas JG (2007) Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J 29(6):1174–1181. doi:10.1183/09031936.00113606

    Article  CAS  PubMed  Google Scholar 

  • Thomen RP, Sheshadri A, Quirk JD, Kozlowski J, Ellison HD, Szczesniak RD, Castro M, Woods JC (2015) Regional ventilation changes in severe asthma after bronchial thermoplasty with (3)He MR imaging and CT. Radiology 274(1):250–259. doi:10.1148/radiol.14140080

    Article  PubMed  Google Scholar 

  • Tkach JA, Hillman NH, Jobe AH, Loew W, Pratt RG, Daniels BR, Kallapur SG, Kline-Fath BM, Merhar SL, Giaquinto RO, Winter PM, Li Y, Ikegami M, Whitsett JA, Dumoulin CL (2012) An MRI system for imaging neonates in the NICU: initial feasibility study. Pediatr Radiol 42(11):1347–1356. doi:10.1007/s00247-012-2444-9

    Article  PubMed  Google Scholar 

  • Tzeng YS, Lutchen K, Albert M (2009) The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized He-3 MRI. J Appl Physiol 106(3):813–822. doi:10.1152/japplphysiol.01133.2007

    Article  PubMed  Google Scholar 

  • van Beek EJ, Dahmen AM, Stavngaard T, Gast KK, Heussel CP, Krummenauer F, Schmiedeskamp J, Wild JM, Sogaard LV, Morbach AE, Schreiber LM, Kauczor HU (2009) Hyperpolarised 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial. Eur Respir J 34(6):1311–1321. doi:10.1183/09031936.00138508

    Article  PubMed  Google Scholar 

  • Vestbo J, Anderson W, Coxson HO, Crim C, Dawber F, Edwards L, Hagan G, Knobil K, Lomas DA, MacNee W, Silverman EK, Tal-Singer R, investigators E (2008) Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J 31(4):869–873. doi:10.1183/09031936.00111707

    Article  CAS  PubMed  Google Scholar 

  • Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R (2013a) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease GOLD executive summary. Am J Respir Crit Care Med 187(4):347–365. doi:10.1164/rccm.201204-0596PP

    Article  CAS  PubMed  Google Scholar 

  • Walkup LL, Tkach JA, Higano NS, Thomen RP, Fain SB, Merhar SL, Fleck RJ, Amin RS, Woods JC (2015) Quantitative magnetic resonance imaging of bronchopulmonary dysplasia in the neonatal intensive care unit environment. Am J Respir Crit Care Med 192(10):1215–1222. doi:10.1164/rccm.201503-0552OC

    Article  PubMed  PubMed Central  Google Scholar 

  • Wheatley A, Mckay S, Mathew L, Santyr G, McCormack DG, Parraga G (2008) Hyperpolarized helium-3 magnetic resonance imaging of asthma: Short-term reproducibility – art. no. 69161X. P Soc Photo-Opt Ins 6916:X9161–X9161. doi:10.1117/12.771138

    Article  Google Scholar 

  • Wielputz MO, Puderbach M, Kopp-Schneider A, Stahl M, Fritzsching E, Sommerburg O, Ley S, Sumkauskaite M, Biederer J, Kauczor HU, Eichinger M, Mall MA (2014) Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease. Am J Respir Crit Care Med 189(8):956–965. doi:10.1164/rccm.201309-1659OC

    Article  PubMed  Google Scholar 

  • Woodhouse N, Wild JM, Paley MN, Fichele S, Said Z, Swift AJ, van Beek EJ (2005) Combined helium-3/proton magnetic resonance imaging measurement of ventilated lung volumes in smokers compared to never-smokers. J Magn Reson Imaging 21(4):365–369. doi:10.1002/jmri.20290

    Article  PubMed  Google Scholar 

  • Woods JC, Choong CK, Yablonskiy DA, Bentley J, Wong J, Pierce JA, Cooper JD, Macklem PT, Conradi MS, Hogg JC (2006) Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema. Magn Reson Med 56(6):1293–1300. doi:10.1002/mrm.21076

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Robarts Research Institute and Department of Medical Biophysics, Western University, 1151 Richmond St N, London, Canada, N6A 5B7

    Dante P. I. Capaldi BSc, Rachel L. Eddy BEng & Grace Parraga PhD

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  1. Dante P. I. Capaldi BSc
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  2. Rachel L. Eddy BEng
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  3. Grace Parraga PhD
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  1. Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany

    Hans-Ulrich Kauczor  & Mark Oliver Wielpütz  & 

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Capaldi, D.P.I., Eddy, R.L., Parraga, G. (2016). Pulmonary MRI in Clinical Trials. In: Kauczor, HU., Wielpütz, M.O. (eds) MRI of the Lung. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_81

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