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MR Perfusion in the Lung

  • Chapter
MRI of the Lung

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Perfusion is the blood flow of an organ at the capillary level. It is closely related to the blood supply of the lung and moreover to lung function. It is altered in various diseases of the lung such as pulmonary hypertension or cystic fibrosis, etc. Therefore, perfusion is an important functional parameter in the diagnosis of pulmonary diseases, and quantitative values are required to study physiology and pathophysiology of various lung diseases as well as to monitor treatment response. The most popular and clinically established approach to measure the pulmonary perfusion using MRI is based on three-dimensional time-resolved contrast-enhanced T1-weighted sequences. The rapid acquisition of perfusion images facilitates the tracking of the first pass of a contrast agent through the lung parenchyma. Based on this information, it is possible to quantify perfusion in the entire lung using the indicator dilution theory. Quantification is challenging due to potential extravasation of the contrast agent during the first pass as well as the nonlinear relationship between the concentration of the contrast agent and signal intensity. Some of these challenges can be addressed by a dual-bolus technique. Alternatively, pulmonary perfusion can be assessed using contrast agent-free approaches such as arterial spin labeling or Fourier decomposition MRI. Application of these techniques can especially benefit patients for whom the contrast agent administration is contraindicated.

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Author information

Authors and Affiliations

  1. Department of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co KG, Birkendorfer Strasse 65, 88397, Biberach, Germany

    Frank Risse PhD

  2. Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Petersgraben 4, 4031, Basel, Switzerland

    Grzegorz Bauman PhD

  3. Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123, Basel, Switzerland

    Grzegorz Bauman PhD

Authors
  1. Frank Risse PhD
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  2. Grzegorz Bauman PhD
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Editors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany

    Hans-Ulrich Kauczor  & Mark Oliver Wielpütz  & 

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Risse, F., Bauman, G. (2016). MR Perfusion in the Lung. In: Kauczor, HU., Wielpütz, M.O. (eds) MRI of the Lung. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_82

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  • DOI: https://doi.org/10.1007/174_2016_82

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42616-7

  • Online ISBN: 978-3-319-42617-4

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