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Noninvasive Coronary Artery Imaging

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Multislice CT

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Current computed tomography (CT) technology enables the noninvasive imaging of the coronary arteries in daily clinical practice. Patients with a low to intermediate likelihood of coronary artery disease (CAD) and having equivocal findings at electrocardiogram (ECG) or stress tests are considered suitable candidates to undergo noninvasive coronary CT angiography. The excellent negative predictive value close to 100 % enables the exclusion of obstructive CAD with certainty. In order to obtain images without artifacts, CT scanner systems need to provide a high temporal and spatial resolution. In addition, several techniques must be applied and combined for minimizing the exposure of patients to ionizing radiation. CT data acquisition needs to be synchronized to the simultaneously recorded ECG for either retrospective, prospective, or high-pitch scanning. Depending on the heart rate of the patients, ECG pulsing windows must be flexibly adjusted. Owing to the steadily increasing temporal resolution of modern CT systems, coronary CT angiography today is possible even at high and/or irregular heart rates.

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References

  • Achenbach S, Daniel WG (2001) Noninvasive coronary angiography – an acceptable alternative? N Engl J Med 345(26):1909–1910

    Article  CAS  PubMed  Google Scholar 

  • Alkadhi H (2009) Praxisbuch Herz-CT. Springer, Heidelberg, XVI, 177 S. p.

    Google Scholar 

  • Alkadhi H, Leschka S (2011) Radiation dose of cardiac computed tomography – what has been achieved and what needs to be done. Eur Radiol 21(3):505–509

    Article  PubMed  Google Scholar 

  • Angelini P (2007) Coronary artery anomalies: an entity in search of an identity. Circulation 115(10):1296–1305

    Article  PubMed  Google Scholar 

  • Angelini P, Velasco JA, Flamm S (2002) Coronary anomalies: incidence, pathophysiology, and clinical relevance. Circulation 105(20):2449–2454

    Article  PubMed  Google Scholar 

  • Arbab-Zadeh A, Miller JM, Rochitte CE, Dewey M, Niinuma H, Gottlieb I et al (2012) Diagnostic accuracy of computed tomography coronary angiography according to pre-test probability of coronary artery disease and severity of coronary arterial calcification. The CORE-64 (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography) International Multicenter Study. J Am Coll Cardiol 59(4):379–387

    Article  PubMed  PubMed Central  Google Scholar 

  • Bamberg F, Sommer WH, Hoffmann V, Achenbach S, Nikolaou K, Conen D et al (2011) Meta-analysis and systematic review of the long-term predictive value of assessment of coronary atherosclerosis by contrast-enhanced coronary computed tomography angiography. J Am Coll Cardiol 57(24):2426–2436

    Article  PubMed  Google Scholar 

  • Cheng Z, Wang X, Duan Y, Wu L, Wu D, Liang C et al (2010) Detection of coronary artery anomalies by dual-source CT coronary angiography. Clin Radiol 65(10):815–822

    Article  CAS  PubMed  Google Scholar 

  • Cury RC, Abbara S, Achenbach S, Agatston A, Berman DS, Budoff MJ et al (2016) Coronary Artery Disease – Reporting and Data System (CAD-RADS): an Expert Consensus Document of SCCT, ACR and NASCI: endorsed by the ACC. JACC Cardiovasc Imaging 9(9):1099–1113

    Article  PubMed  Google Scholar 

  • Dappa E, Higashigaito K, Fornaro J, Leschka S, Wildermuth S, Alkadhi H (2016) Cinematic rendering – an alternative to volume rendering for 3D computed tomography imaging. Insights Imaging 1–8. doi:10.1007/s13244-016-0518-1

  • den Harder AM, Willemink MJ, de Jong PA, Schilham AM, Rajiah P, Takx RA et al (2016) New horizons in cardiac CT. Clin Radiol 71(8):758–767

    Article  Google Scholar 

  • Desjardins B, Kazerooni EA (2004) ECG-gated cardiac CT. AJR Am J Roentgenol 182(4):993–1010

    Article  PubMed  Google Scholar 

  • Douglas PS, Hoffmann U, Patel MR, Mark DB, Al-Khalidi HR, Cavanaugh B et al (2015) Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med 372(14):1291–1300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dougoud S, Fuchs TA, Stehli J, Clerc OF, Buechel RR, Herzog BA et al (2014) Prognostic value of coronary CT angiography on long-term follow-up of 6.9 years. Int J Card Imaging 30(5):969–976. doi:10.1007/s10554-014-0420-1

  • Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN et al (2004) Sudden death in young adults: a 25-year review of autopsies in military recruits. Ann Intern Med 141(11):829–834

    Article  PubMed  Google Scholar 

  • Flohr TG, McCollough CH, Bruder H, Petersilka M, Gruber K, Suss C et al (2006) First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol 16(2):256–268

    Article  PubMed  Google Scholar 

  • Gasparovic H, Rybicki FJ, Millstine J, Unic D, Byrne JG, Yucel K et al (2005) Three dimensional computed tomographic imaging in planning the surgical approach for redo cardiac surgery after coronary revascularization. Eur J Cardiothorac Surg 28(2):244–249

    Article  PubMed  Google Scholar 

  • Goldstein JA, Chinnaiyan KM, Abidov A, Achenbach S, Berman DS, Hayes SW et al (2011) The CT-STAT (coronary computed tomographic angiography for systematic triage of acute chest pain patients to treatment) trial. J Am Coll Cardiol 58(14):1414–1422

    Article  PubMed  Google Scholar 

  • Gordic S, Husarik DB, Desbiolles L, Leschka S, Frauenfelder T, Alkadhi H (2014) High-pitch coronary CT angiography with third generation dual-source CT: limits of heart rate. Int J Card Imaging 30(6):1173–1179

    Article  Google Scholar 

  • Gordic S, Desbiolles L, Sedlmair M, Manka R, Plass A, Schmidt B et al (2016) Optimizing radiation dose by using advanced modelled iterative reconstruction in high-pitch coronary CT angiography. Eur Radiol 26(2):459–468

    Article  PubMed  Google Scholar 

  • Hadamitzky M, Achenbach S, Al-Mallah M, Berman D, Budoff M, Cademartiri F et al (2013a) Optimized prognostic score for coronary computed tomographic angiography: results from the CONFIRM registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: an InteRnational Multicenter Registry). J Am Coll Cardiol 62(5):468–476

    Article  PubMed  Google Scholar 

  • Hadamitzky M, Taubert S, Deseive S, Byrne RA, Martinoff S, Schomig A et al (2013b) Prognostic value of coronary computed tomography angiography during 5 years of follow-up in patients with suspected coronary artery disease. Eur Heart J 34(42):3277–3285

    Article  PubMed  Google Scholar 

  • Hamilton-Craig C, Fifoot A, Hansen M, Pincus M, Chan J, Walters DL et al (2014) Diagnostic performance and cost of CT angiography versus stress ECG – a randomized prospective study of suspected acute coronary syndrome chest pain in the emergency department (CT-COMPARE). Int J Cardiol 177(3):867–873

    Article  PubMed  Google Scholar 

  • Herzog C, Nguyen SA, Savino G, Zwerner PL, Doll J, Nielsen CD et al (2007) Does two-segment image reconstruction at 64-section CT coronary angiography improve image quality and diagnostic accuracy? Radiology 244(1):121–129

    Article  PubMed  Google Scholar 

  • Higashigaito K, Husarik DB, Barthelmes J, Plass AR, Manka R, Maisano F et al (2016) Computed tomography angiography of coronary artery bypass grafts: low contrast media volume protocols adapted to tube voltage. Investig Radiol 51(4):241–248

    Article  Google Scholar 

  • Hoffmann U, Truong QA, Schoenfeld DA, Chou ET, Woodard PK, Nagurney JT et al (2012) Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med 367(4):299–308

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lell MM, Anders K, Uder M, Klotz E, Ditt H, Vega-Higuera F et al (2006) New techniques in CT angiography. Radiographics 26(Suppl 1):S45–S62

    Article  PubMed  Google Scholar 

  • Leschka S, Scheffel H, Desbiolles L, Plass A, Gaemperli O, Valenta I et al (2007) Image quality and reconstruction intervals of dual-source CT coronary angiography: recommendations for ECG-pulsing windowing. Investig Radiol 42(8):543–549

    Article  Google Scholar 

  • Litt HI, Gatsonis C, Snyder B, Singh H, Miller CD, Entrikin DW et al (2012) CT angiography for safe discharge of patients with possible acute coronary syndromes. N Engl J Med 366(15):1393–1403

    Article  CAS  PubMed  Google Scholar 

  • Luccichenti G, Cademartiri F, Pezzella FR, Runza G, Belgrano M, Midiri M et al (2005) 3D reconstruction techniques made easy: know-how and pictures. Eur Radiol 15(10):2146–2156

    Article  PubMed  Google Scholar 

  • Maier W, Abay M, Cook S, Togni M, Zeiher A, Meier B et al (2006) The 2002 European registry of cardiac catheter interventions. Int J Cardiol 113(3):299–304

    Article  PubMed  Google Scholar 

  • Meinel FG, Bayer RR 2nd, Zwerner PL, De Cecco CN, Schoepf UJ, Bamberg F (2015) Coronary computed tomographic angiography in clinical practice: state of the art. Radiol Clin N Am 53(2):287–296

    Article  PubMed  Google Scholar 

  • Menke J, Unterberg-Buchwald C, Staab W, Sohns JM, Seif Amir Hosseini A, Schwarz A (2013) Head-to-head comparison of prospectively triggered vs retrospectively gated coronary computed tomography angiography: meta-analysis of diagnostic accuracy, image quality, and radiation dose. Am Heart J 165(2):154–63.e3

    Article  PubMed  Google Scholar 

  • Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M et al (2015) Heart disease and stroke statistics – 2015 update: a report from the American Heart Association. Circulation 131(4):e29–322

    PubMed  Google Scholar 

  • Ong TK, Chin SP, Liew CK, Chan WL, Seyfarth MT, Liew HB et al (2006) Accuracy of 64-row multidetector computed tomography in detecting coronary artery disease in 134 symptomatic patients: influence of calcification. Am Heart J 151(6):1323.e1–1323.e6

    Article  PubMed  Google Scholar 

  • Raff GL, Gallagher MJ, O’Neill WW, Goldstein JA (2005) Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. J Am Coll Cardiol 46(3):552–557

    Article  PubMed  Google Scholar 

  • SCOT-HEART Investigators (2015) CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): an open-label, parallel-group, multicentre trial. Lancet 385(9985):2383–2391

    Article  Google Scholar 

  • Shi H, Aschoff AJ, Brambs HJ, Hoffmann MH (2004) Multislice CT imaging of anomalous coronary arteries. Eur Radiol 14(12):2172–2181

    Article  PubMed  Google Scholar 

  • Taylor AJ, Cerqueira M, Hodgson JM, Mark D, Min J, O’Gara P et al (2010) ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography. A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. J Am Coll Cardiol 56(22):1864–1894

    Article  PubMed  Google Scholar 

  • von Ballmoos MW, Haring B, Juillerat P, Alkadhi H (2011) Meta-analysis: diagnostic performance of low-radiation-dose coronary computed tomography angiography. Ann Intern Med 154(6):413–420

    Article  Google Scholar 

  • Vorre MM, Abdulla J (2013) Diagnostic accuracy and radiation dose of CT coronary angiography in atrial fibrillation: systematic review and meta-analysis. Radiology 267(2):376–386

    Article  PubMed  Google Scholar 

  • Wever-Pinzon O, Romero J, Kelesidis I, Wever-Pinzon J, Manrique C, Budge D et al (2014) Coronary computed tomography angiography for the detection of cardiac allograft vasculopathy: a meta-analysis of prospective trials. J Am Coll Cardiol 63(19):1992–2004

    Article  PubMed  Google Scholar 

  • Wolk MJ, Bailey SR, Doherty JU, Douglas PS, Hendel RC, Kramer CM et al (2014) ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol 63(4):380–406

    Article  PubMed  Google Scholar 

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Correspondence to Hatem Alkadhi MD, MPH, EBCR .

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Mannil, M., Alkadhi, H. (2017). Noninvasive Coronary Artery Imaging. In: Nikolaou, K., Bamberg, F., Laghi, A., Rubin, G.D. (eds) Multislice CT. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_89

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  • DOI: https://doi.org/10.1007/174_2016_89

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  • Online ISBN: 978-3-319-42586-3

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