Abstract
Literature concerning mass transfer in bubble columns and loop reactors contains numerous data on small-scale units. On the other hand, data on the production scale, i.e. reactor diameters exceeding 1 m, are scarce. The present work tries to apply the data that are available to the calculation of a loop reactor. The metabolic reaction itself is performed in each single cell. A careful consideration of the statistics in cell-medium systems is used as a necessary background for an economic reactor design. Based on this fact, the actual supply of each cell is discussed for the growth of Methylomonas clara on methanol.
Most of the literature takes for granted that the calculation of gas-liquid oxygen transfer, i.e. the transportation from the bubble to the liquid layer, describes the real problem. It is shown by reasonable assumptions that the further oxygen transport from the gas-liquid film to each individual microorganism must be considered as well. In addition, the importance of macro- and micro-mixing for the scale-up procedure are pointed out.
For a medium-sized reactor of 300 m3 total volume, the main features of scale-up calculations are considered. Little data being published, the zones of critically low supply are studied using rough estimates. The advantages and limitations of an air-lift loop reactor compared to those of stirred tank reactors are discussed.
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Faust, U., Sittig, W. (1980). Methanol as carbon source for biomass production in a loop reactor. In: Advances in Biochemical Engineering, Volume 17. Advances in Biochemical Engineering, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-09955-7_8
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