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Clinical Aspects of MALT

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Uveitis and Immunological Disorders

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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References

  1. Abu El-Asrar AM, Geboes K, al-Kharashi S, Tabbara KF, Missotten L, Desmet V (1997) Adhesion molecules in vernal keratoconjunctivitis. Br J Ophthalmol 81:1099–1106

    PubMed  Google Scholar 

  2. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252

    Article  PubMed  Google Scholar 

  3. Bielory L, Mongia A (2002) Current opinion of immunotherapy for ocular allergy. Curr Opin Allergy Clin Immunol 2:447–452

    Article  PubMed  Google Scholar 

  4. Brandtzaeg P, Baekkevold ES, Morton HC (2001) From B to A the mucosal way. Nat Immunol 2:1093–1094

    PubMed  Google Scholar 

  5. Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272:60–66

    PubMed  Google Scholar 

  6. Dua HS, Gomes JA, Jindal VK, Appa SN, Schwarting R, Eagle RC Jr, Donoso LA, Laibson PR (1994) Mucosa specific lymphocytes in the human conjunctiva, corneoscleral limbus and lacrimal gland. Curr Eye Res 13:87–93

    PubMed  Google Scholar 

  7. Fox RI (1998) Sjogren's syndrome. Pathogenesis and new approaches to therapy. Adv Exp Med Biol 438:891–902

    PubMed  Google Scholar 

  8. Fox RI, Stern M (2002) Sjogren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems. Scand J Rheumatol Suppl 2002:3–13

    Article  Google Scholar 

  9. Fukagawa K, Tsubota K, Simmura S, Saito H, Tachimoto H, Akasawa A, Oguchi Y (1998) Chemokine production in conjunctival epithelial cells. Adv Exp Med Biol 438:471–478

    PubMed  Google Scholar 

  10. Galli SJ, Gordon JR, Wershil BK (1993) Mast cell cytokines in allergy and inflammation. Agents Actions Suppl 43:209–220

    PubMed  Google Scholar 

  11. Gallucci S, Matzinger P (2001) Danger signals: SOS to the immune system. Curr Opin Immunol 13:114–119

    PubMed  Google Scholar 

  12. Gamache DA, Dimitrijevich SD, Weimer LK, Lang LS, Spellman JM, Graff G, Yanni JM (1997) Secretion of proinflammatory cytokines by human conjunctival epithelial cells. Ocul Immunol Inflamm 5:117–128

    PubMed  Google Scholar 

  13. Garrana RM, Zieske JD, Assouline M, Gipson IK (1999) Matrix metalloproteinases in epithelia from human recurrent corneal erosion. Invest Ophthalmol Vis Sci 40:1266–1270

    PubMed  Google Scholar 

  14. Gilbard J (1985) Tear film osmolarity and keratoconjunctivitis sicca. In: Holly FJ (ed) Proc 1 Int Tear Film Symposium, Lubbock, Texas, pp 127–139

    Google Scholar 

  15. Hamrah P, Zhang Q, Liu Y, Dana MR (2002) Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci 43:639–646

    Google Scholar 

  16. Hingorani M, Calder VL, Buckley RJ, Lightman S (1999) The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. Invest Ophthalmol Vis Sci 40:392–399

    PubMed  Google Scholar 

  17. Hingorani M, Calder VL, Buckley RJ, Lightman SL (1998) The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp Eye Res 67:491–500

    Article  PubMed  Google Scholar 

  18. Hingorani M, Metz D, Lightman SL (1997) Characterisation of the normal conjunctival leukocyte population. Exp Eye Res 64:905–912

    Article  PubMed  Google Scholar 

  19. Iwasaki A, Kelsall BL (1999) Mucosal immunity and inflammation. I. Mucosal dendritic cells: their specialized role in initiating T cell responses. Am J Physiol 276:G1074–G1078

    PubMed  Google Scholar 

  20. Katelaris CH (2003) Ocular allergy: implications for the clinical immunologist. Ann Allergy Asthma Immunol 90:23–27

    Google Scholar 

  21. Knop E, Claus P, Knop N (2003) Eye-associated lymphoid tissue (EALT): RT-PCR verifies the presence of mRNA for IgA and its transporter (secretory component) in the normal human conjunctiva. Invest Ophthalmol Vis Sci 44:S3801

    Google Scholar 

  22. Knop E, Knop N (2001) Lacrimal drainage associated lymphoid tissue (LDALT): a part of the human mucosal immune system. Invest Ophthalmol Vis Sci 2001:566–574

    Google Scholar 

  23. Knop E, Knop N (2002) A functional unit for ocular surface immune defense formed by the lacrimal gland, conjunctiva and lacrimal drainage system. Adv Exp Med Biol 506:835–844

    PubMed  Google Scholar 

  24. Knop E, Knop N (2002) Human lacrimal drainage-associated lymphoid tissue (LDALT) belongs to the common mucosal immune system. Adv Exp Med Biol 506:861–866

    PubMed  Google Scholar 

  25. Knop E, Knop N (2003) [Eye-associated lymphoid tissue (EALT) is continuously spread throughout the ocular surface from the lacrimal gland to the lacrimal drainage system]. Ophthalmologe 100:929–942

    PubMed  Google Scholar 

  26. Knop E, Knop N (2004) Lymphocyte homing in the mucosal immune system to the eye-associated lymphoid tissue (EALT). In: Zierhut M, Sullivan DA, Stern ME (eds) Immunology of the ocular surface and tearfilm. Swets & Zeitlinger, Amsterdam

    Google Scholar 

  27. Knop E, Knop N, Brewitt H (2003) [Dry eye disease as a complex dysregulation of the functional anatomy of the ocular surface. New impulses to understanding dry eye disease]. Ophthalmologe 100:917–928

    Article  PubMed  Google Scholar 

  28. Knop N, Knop E (2000) Conjunctiva-associated lymphoid tissue in the human eye. Invest Ophthalmol Vis Sci 41:1270–1279

    PubMed  Google Scholar 

  29. Kraehenbuhl JP, Neutra MR (1992) Molecular and cellular basis of immune protection of mucosal surfaces. Physiol Rev 72:853–879

    PubMed  Google Scholar 

  30. Lemp MA (1995) Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eyes. CLAO J 21:221–232

    PubMed  Google Scholar 

  31. Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC (2001) Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res 73:449–459

    Article  PubMed  Google Scholar 

  32. Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana MR (2002) Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med 195:259–268

    PubMed  Google Scholar 

  33. Liu Z, Sun YK, Xi YP, Maffei A, Reed E, Harris P, Suciu-Foca N (1993) Contribution of direct and indirect recognition pathways to T cell alloreactivity. J Exp Med 177:1643–1650

    Article  PubMed  Google Scholar 

  34. MacDonald TT, Bajaj-Elliott M, Pender SL (1999) T cells orchestrate intestinal mucosal shape and integrity. Immunol Today 20:505–510

    Article  PubMed  Google Scholar 

  35. McMenamin PG, Crewe J, Morrison S, Holt PG (1994) Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye. Invest Ophthalmol Vis Sci 35:3234–3250

    PubMed  Google Scholar 

  36. Meller D, Li DQ, Tseng SC (2000) Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1 beta and tumor necrosis factor-alpha. Invest Ophthalmol Vis Sci 41:2922–2929

    PubMed  Google Scholar 

  37. Mellman I, Steinman RM (2001) Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255–258

    Article  PubMed  Google Scholar 

  38. Metz DP, Hingorani M, Calder VL, Buckley RJ, Lightman SL (1997) T-cell cytokines in chronic allergic eye disease. J Allergy Clin Immunol 100:817–824

    PubMed  Google Scholar 

  39. Morgan SJ, Williams JH, Walls AF, Church MK, Holgate ST, McGill JI (1991) Mast cell numbers and staining characteristics in the normal and allergic human conjunctiva. J Allergy Clin Immunol 87:111–116

    Article  PubMed  Google Scholar 

  40. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348–2357

    PubMed  Google Scholar 

  41. Nelson JD, Helms H, Fiscella R, Southwell Y, Hirsch JD (2000) A new look at dry eye disease and its treatment. Adv Ther 17:84–93

    PubMed  Google Scholar 

  42. Novak N, Siepmann K, Zierhut M, Bieber T (2003) The good, the bad and the ugly — APCs of the eye. Trends Immunol 24:570–574

    Article  PubMed  Google Scholar 

  43. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, Yamada A, Itoh K, Nomoto K (1996) Cytokine messenger RNA expression in the labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 39:1376–1384

    PubMed  Google Scholar 

  44. Osterlind G (1944) An investigation into the presence of lymphatic tissue in the human conjunctiva, and its biological and clinical importance. Acta Ophthalmol Copenh Suppl 23:1–79

    Google Scholar 

  45. Paulsen FP, Paulsen JI, Thale AB, Schaudig U, Tillmann BN (2002) Organized mucosa-associated lymphoid tissue in human naso-lacrimal ducts. Adv Exp Med Biol 506:873–876

    PubMed  Google Scholar 

  46. Pepose JS, Akata RF, Pflugfelder SC, Voigt W (1990) Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjogren's syndrome. Ophthalmology 97:1599–1605

    PubMed  Google Scholar 

  47. Pflugfelder SC (2004) Antiinflammatory therapy for dry eye. Am J Ophthalmol 137:337–342

    Article  PubMed  Google Scholar 

  48. Pflugfelder SC, Solomon A, Stern ME (2000) The diagnosis and management of dry eye: a twenty-five-year review. Cornea 19:644–649

    Article  PubMed  Google Scholar 

  49. Pflugfelder SC, Tseng SC, Yoshino K, Monroy D, Felix C, Reis BL (1997) Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology 104:223–235

    PubMed  Google Scholar 

  50. Pleyer U, Dannowski H, Volk HD, Ritter T (2001) Corneal allograft rejection: current understanding. 2. Immunobiology and basic mechanisms. Ophthalmologica 215:254–262

    Article  PubMed  Google Scholar 

  51. Pleyer U, Ritter T (2003) Gene therapy in immune-mediated diseases of the eye. Prog Retin Eye Res 22:277–293

    Article  PubMed  Google Scholar 

  52. Rhodus NL (1999) Sjogren's syndrome. Quintessence Int 30:689–699

    PubMed  Google Scholar 

  53. Sacks EH, Wieczorek R, Jakobiec FA, Knowles DM (1986) Lymphocytic subpopulations in the normal human conjunctiva. A monoclonal antibody study. Ophthalmology 93:1276–1283

    PubMed  Google Scholar 

  54. Sall K, Stevenson OD, Mundorf TK, Reis BL (2000) Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 107:631–639

    Article  PubMed  Google Scholar 

  55. Sayegh MH, Turka LA (1998) The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 338:1813–1821

    Article  PubMed  Google Scholar 

  56. Schaumberg DA, Sullivan DA, Dana MR (2002) Epidemiology of dry eye syndrome. Adv Exp Med Biol 506:989–998

    PubMed  Google Scholar 

  57. Stahl JL, Cook EB, Barney NP, Graziano FM (2002) Pathophysiology of ocular allergy: the roles of conjunctival mast cells and epithelial cells. Curr Allergy Asthma Rep 2:332–339

    PubMed  Google Scholar 

  58. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–589

    Article  PubMed  Google Scholar 

  59. Stern ME, Gao J, Schwalb TA, et al. (2002) Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest Ophthalmol Vis Sci 43:2609–2614

    PubMed  Google Scholar 

  60. Sullivan DA, Edwards JA (1997) Androgen stimulation of lacrimal gland function in mouse models of Sjogren's syndrome. J Steroid Biochem Mol Biol 60:237–245

    Article  PubMed  Google Scholar 

  61. von Andrian UH, Mackay CR (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343:1020–1034

    Article  PubMed  Google Scholar 

  62. Wedemeyer J, Tsai M, Galli SJ (2000) Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol 12:624–631

    Article  PubMed  Google Scholar 

  63. Westermann J, Engelhardt B, Hoffmann JC (2001) Migration of T cells in vivo: molecular mechanisms and clinical implications. Ann Intern Med 135:279–295

    PubMed  Google Scholar 

  64. Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM (1988) The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions. Ophthalmology 95:100–109

    PubMed  Google Scholar 

  65. Worda C, Nepp J, Huber JC, Sator MO (2001) Treatment of keratoconjunctivitis sicca with topical androgen. Maturitas 37:209–212

    Article  PubMed  Google Scholar 

  66. Yokoi K, Yokoi N, Kinoshita S (1998) Impairment of ocular surface epithelium barrier function in patients with atopic dermatitis. Br J Ophthalmol 82:797–800

    PubMed  Google Scholar 

  67. Zelenika D, Adams E, Humm S, Lin CY, Waldmann H, Cobbold SP (2001) The role of CD4+ T-cell subsets in determining transplantation, rejection or tolerance. Immunol Rev 182:164–179

    Article  PubMed  Google Scholar 

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Authors
  1. Erich Knop
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  2. Nadja Knop
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  3. Uwe Pleyer
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Editor information

Editors and Affiliations

  1. Ophthalmology, Augenklinik Charité, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany

    Günther K. Krieglstein MD (Professor) (Professor)

  2. Ophthalmology, Jules Stein Eye Institute, 100 Stein Plaza #2-142, Los Angeles, CA, 90095-7000, USA

    Robert N. Weinreb MD (Professor) (Professor)

  3. Department of Ophthalmology, University of Cologne, Joseph-Stelzmann-Straße 9, 50931, Cologne, Germany

    Uwe Pleyer MD (Professor) (Professor)

  4. Hamilton Glaucoma Center Department of Ophthalmology - 0946, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA

    Bartly Mondino MD (Professor) (Professor)

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© 2005 Springer-Verlag Berlin Heidelberg

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Knop, E., Knop, N., Pleyer, U. (2005). Clinical Aspects of MALT. In: Krieglstein, G.K., Weinreb, R.N., Pleyer, U., Mondino, B. (eds) Uveitis and Immunological Disorders. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26752-2_6

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  • DOI: https://doi.org/10.1007/3-540-26752-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20045-1

  • Online ISBN: 978-3-540-26752-2

  • eBook Packages: MedicineMedicine (R0)

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