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Noninvasive Real-Time In Vivo Bloluminescent Imaging of Gene Expression and of Tumor Progression and Metastasis

  • Conference paper
Molecular Imaging

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 49))

11.6 Conclusions and Future Perspectives

It is clear from the work presented in this chapter and from work by others that BLI is perfectly suited to monitor gene expression in transgenic reporter mice and to detect and follow small numbers of cells noninvasively. As we have shown, it also enables the quantification of tumor cells within internal organs in animal models of cancer. BLI is a powerful tool in functional genomics of cancer development, progression, and metastasis and will allow us to identify in vivo molecular targets of cancer and their metastasis. The application of BLI in combination with new animal models for cancer will allow us to study very rapidly and conveniently the efficacy of new therapeutic approaches such as gene therapy stem cell therapy and antiangiogenic therapy, and when successful can be a first step towards clinical application. Furthermore, the development of new smart luciferase-based reporter constructs as well as new possibilities to create transgenic animals containing these reporter constructs will make noninvasive in vivo BLI also a powerful new tool in other small animal models of human biology and disease.

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Authors and Affiliations

  1. Department of Endocrinology, Building 1, C4-R86 Leiden University Medical Center, Albinusdreet 2, 2333 ZA, Leiden, The Netherlands

    C. W. G. M. Lowik & G. van der Pluijm

  2. Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, MEM C813, Murtenstr. 35, 3010, Bern, Switzerland

    M. G. Cecchini

  3. Department of Pharmacological Sciences and Center of Excellence on Neurogenerative Disease, University of Milan, Italy

    A. Maggi

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  1. C. W. G. M. Lowik
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  2. M. G. Cecchini
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  3. A. Maggi
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  4. G. van der Pluijm
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Editors and Affiliations

  1. Center for Molecular Imaging Research, Building 149, Massachusetts General Hospital, 13th Street, Charleston, MA, 02129, USA

    A. A. Bogdanov Jr.

  2. Medicinal Chemistry 6, Schering AG, Müllerstr. 170-178, 13342, Berlin, Germany

    K. Licha

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Lowik, C.W.G.M., Cecchini, M.G., Maggi, A., van der Pluijm, G. (2005). Noninvasive Real-Time In Vivo Bloluminescent Imaging of Gene Expression and of Tumor Progression and Metastasis. In: Bogdanov, A.A., Licha, K. (eds) Molecular Imaging. Ernst Schering Research Foundation Workshop, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26809-X_11

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