Conclusions
Conventional MR imaging can show macroscopic white matter signal changes in degenerative diseases of the CNS which are a useful diagnostic tool for FTD, OPCA, SA, and PLS/ALS.
Non-conventional MR, including DTI, MT and 1H-MRS, demonstrates abnormalities of the white matter in almost every degenerative disease of the CNS. These white matter changes are variably correlated to the severity of the clinical deficit and are currently evaluated as markers of disease progression and possible surrogate markers in pharmacological trials.
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Mascalchi, M. (2005). Neurodegenerative Diseases with Associated White Matter Pathology. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_26
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