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HDV RNA Replication: Ancient Relic or Primer?

  • Chapter
Hepatitis Delta Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 307))

Abstract

HDV replicates its circular RNA genome using a double rolling-circle mechanism and transcribes a hepatitis delta antigen-encodeing mRNA from the same RNA template during its life cycle. Both processes are carried out by RNA-dependent RNA synthesis despite the fact that HDV does not encode an RNA-dependent RNA polymerase (RdRP). Cellular RNA polymerase II has long been implicated in these processes. Recent findings, however, have shown that the syntheses of genomic and antigenomic RNA strands have different metabolic requirements, including sensitives to α-amanitin and the site of synthesis. Evidence is summarized here for the involvement of other cellular polymerases, probably pol I, in the synthesis of antigenomic RNA strand. The ability of mammalian cells to replicate HDV RNA implies that RNA-dependent RNA synthesis was preserved throughout evolution.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA

    T. B. Macnaughton & M. M. C. Lai

  2. Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, 115, Taiwan

    M. M. C. Lai

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  1. T. B. Macnaughton
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  2. M. M. C. Lai
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Editors and Affiliations

  1. Department of Microbiology and Immunology, Georgetown University, 3900 Reservoir Road, NW, Washington, DC, 20007, USA

    John L. Casey Ph.D.

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Macnaughton, T.B., Lai, M.M.C. (2006). HDV RNA Replication: Ancient Relic or Primer?. In: Casey, J.L. (eds) Hepatitis Delta Virus. Current Topics in Microbiology and Immunology, vol 307. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29802-9_2

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