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Specificity and Plasticity of Memory LymphocyteMigration

  • Chapter
Gut-Associated Lymphoid Tissues

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 308))

Abstract

To exert immunological activity, T and B cells must leave the blood and enter different extravascular compartments in the body. An essential step in this process is their adhesion to microvascular endothelium and subsequent diapedesis into a target tissue. Naive and effector/memory T and B cells possess distinct repertoires of traffic molecules that restrict their ability to interact with specialized microvessels in different anatomic compartments and thus exhibit distinct patterns of migration. In addition, antigen-experienced lymphocytes are subdivided into different subsets based on their expression of characteristic sets of adhesion receptors that favor their accumulation in certain target organs, such as the skin and the gut. This article focuses on recent discoveries that have broadened our understanding of the “imprinting” mechanisms responsible for the generation of tissue-specific effector/memory lymphocytes, especially in the intestine. We discuss how gut-specific homing is acquired, maintained, and modulated and how these mechanisms might be harnessed to develop improved vaccine protocols and treatments for intestinal autoimmune diseases.

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Authors and Affiliations

  1. CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Ave, Boston, MA, 02115, USA

    J. Rodrigo Mora & U. H. von Andrian

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  1. Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan

    Tasuku Honjo MD, Ph.D.

  2. Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstr. 50-70, 4056, Basel, Switzerland

    Fritz Melchers

  3. Max Planck Institute for Infection Biology, Campus Charité, Schumannstrasse 21-22, 10117, Berlin, Germany

    Fritz Melchers

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Mora, J.R., von Andrian, U.H. (2006). Specificity and Plasticity of Memory LymphocyteMigration. In: Honjo, T., Melchers, F. (eds) Gut-Associated Lymphoid Tissues. Current Topics in Microbiology and Immunology, vol 308. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30657-9_4

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