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Integrated Chip-Based Microcolumn Separation Systems

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Microsystem Technology in Chemistry and Life Science

Part of the book series: Topics in Current Chemistry ((4143,volume 194))

Abstract

The prospects of inexpensive mass production of integrated chemical separation systems with superior analytical performance through modern microfabrication technology has stimulated considerable research activity over the past five years. In addition, these devices hold the promise of being extremely rugged, capable of analysis of very small sample volumes, and suitable for high-throughput analysis through parallel sample processing. The goal of the present article is to review major recent accomplishments in this rapidly advancing field. Since most research efforts up to now have been devoted to electric field driven separation systems, in particular to chip-based capillary electrophoresis, emphasis will be laid on the discussion of the physical-chemical basis of the operation and optimization of these devices.

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Author information

Authors and Affiliations

  1. Bioanalytical Research, K-127.1.84, Novartis Pharma AG, CH-4002, Basel, Switzerland

    Carlo S. Effenhauser

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  1. Carlo S. Effenhauser
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Editors and Affiliations

  1. Department of Chemistry Imperial College of Science and Technology, Zeneca/Smithkline Beecham Centre for Analytical Sciences, South Kensington London, SW7 2AY

    Andreas Manz  & Holger Becker  & 

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© 1998 Springer Verlag Berlin Heidelberg

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Effenhauser, C.S. (1998). Integrated Chip-Based Microcolumn Separation Systems. In: Manz, A., Becker, H. (eds) Microsystem Technology in Chemistry and Life Science. Topics in Current Chemistry, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-69544-3_3

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  • DOI: https://doi.org/10.1007/3-540-69544-3_3

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