Skip to main content
SpringerLink
Log in

Heterotope Ossifikationen — experimentelle und klinische Aspekte

  • Chapter
Fortbildung Osteologie 1

Part of the book series: Fortbildung Osteologie ((FORTOSTEO,volume 1))

  • 669 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ahn J, Serrano de la Pena L, Shore EM, Kaplan FS (2003) Paresis of a bone morphogenetic protein-antagonist response in a genetic disorder of heterotopic skeletogenesis. J Bone Joint Surg Am 85:667–674

    PubMed  Google Scholar 

  • Arcq M (1973) Die paraartikuläre Ossifikation — eine Komplikation der Totalendoprothese des Hüftge-lenkes. Arch orthop Unfall-Chir 77:108–131

    Article  CAS  Google Scholar 

  • Aspenberg P, Lohmander SL, Thorngren KG (1988) Failure of bone induction by bone matrix in adult monkeys. J Bone Joint Surg 70-B:625–627

    Google Scholar 

  • Ashton BA, Allen CR, Howlett CR, Eaglesom CC, Hattori A, Owen M (1980) Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop and Rel Res 151:294–307

    Google Scholar 

  • Baldus SE, Mönig SP, Schneider PM, Hölscher AH, Dienes HP (2002) Adenokarzinom des Magens mit heterotoper Ossifikation. Der Pathologe 2:156–160

    Google Scholar 

  • Blasingname JP, Resnick D, Coutts RD, Danzig LA (1981) Extensive Spinal Osteophytosis as a Risk Factor for Heterotopic Bone Formation after Total Hip Arthroplasty. Clinical Orthopedics and Related Research 161:191–197

    Google Scholar 

  • Bona C, Stanecu V, Dumitrescu MS, Ionescu V (1967) Histochemical and cytoenzymological studies in myositis ossificans. Acta Histochem 27:207–224

    PubMed  CAS  Google Scholar 

  • Brunet LJ, McMahon JA, McMahon AP, Harland RM (1998) Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton, Science 280:1455–1457

    Article  PubMed  CAS  Google Scholar 

  • Buring K (1975) On the origin of cells in heterotopic bone formation. Clin Orthop 110:293–302

    PubMed  Google Scholar 

  • Canalis E, Peck A, Raisz LG (1980) Stimulation of DNA and collagen synthesis by autogenous growth factor in cultured fetal rat calvaria. Science 210:1021–1023

    PubMed  CAS  Google Scholar 

  • Charnley J (1972) The long-term results of low-friction arthroplasty of hip performed as primary intervention. J Bone and Joint Surg 54:B:61–78

    CAS  Google Scholar 

  • Cohen RB, Hahn GV, Tabas JA, Peeper J, Levitz LC, Sando A, Sando N, Zasloff M, Kaplan FS (1993) The Natural History of Heterotopic Ossification in Patients Who Have Fibrodysplasia Ossificans Progressiva. J Bone and Joint Surg 75-A:215–219

    Google Scholar 

  • Connor JM (1983) Soft tissue ossification. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Drivdahl RHG, Howard A, Baylink DJ (1982) Extracts of bone contain a potent regulator of bone formation. Biochem Biophys Acta 714:26–33

    PubMed  CAS  Google Scholar 

  • Farley JR, Baylink DJ (1982) Purification of a skeletal growth factor from human bone. Biochemistry 21:3502–3513

    PubMed  CAS  Google Scholar 

  • Evans EB (1991) Heterotopic bone formation in thermal burns. Clin Orthop 263:94–101

    PubMed  Google Scholar 

  • Faupel L, Kunze A, Schulz A, Kafurke H (1987) Die Durchblutung autologer korticospongiöser Transplantate. Hefte z Unfallheilk 185:65–68

    Google Scholar 

  • Friedenstein AY, Lalykina KS, Tolmacheva AA (1968) Osteogenic activity of peritoneal fluid cells induced by transitional epithelium. Acta Anat 68:532

    Google Scholar 

  • Friedenstein AY (1973) Determined and inducible osteogenetic precursor cells. In: Hard tissue growth, repair and remineralization. Ciba Foundation Symposium II. Elsevier, New York, pp 169–181

    Google Scholar 

  • Friedenstein AY (1976) Precursor cells of mechanocytes. Int Rev Cytol 47:327–355

    PubMed  CAS  Google Scholar 

  • Friedenstein AY (1990) Osteogenic stem cells in the bone marrow. In: Heersche JNM, Kanis JA (eds) Bone and Mineral Research/7. Elsevier Science Publishers BV

    Google Scholar 

  • Gehron Robey P, Young MF, Flanders KC, Roche NS, Kondaiah P, Reddi AH, Termine JD, Sporn MB, Roberts AB (1987) Osteoblast synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. J Cell Biol 105:457–463

    Google Scholar 

  • Glowacki J, Kaban LB, Murray JE, Folkman J, Mulliken JB (1981) Application of the biological principle of induced osteogenesis for craniofascial defects. Lancet 959–962

    Google Scholar 

  • Glowacki J, Cox KA (1986) Osteoclastic features of cells that resorb bone implants in rats. Calcif Tissue Int 39:97

    PubMed  CAS  Google Scholar 

  • Glowacki J, Jasty M, Goldring SR (1986) Comparison of multinucleated cells elicited in rats by particulate bone, polyethylene, or polymethylmethacrylate. J Bone Miner Res 1:327

    PubMed  CAS  Google Scholar 

  • Goldhaber P (1961) Osteogenic induction across millipore filters in vivo. Science 133:2065–2067

    PubMed  CAS  Google Scholar 

  • Groves EWH (1917) Methods and results of transplantation of bone in the repair of defects. Br J Surg 5:185–204

    Google Scholar 

  • Haga F (1904) Über Myositis ossificans traumatica (Reit-und Exerzierknochen). Arch Klin Chir 72:64–78

    Google Scholar 

  • Huggins CB (1929) Influence of urinary tract mucosa on the experimental formation of bone. Proc Soc Exp Biol Med, Vol XXVII, pp 349–350

    Google Scholar 

  • Huggins CB (1931) The phosphatase activity of transplants of the epithelium of the urinary bladder to the abdominal wall producing heterotopic ossification. Biochem J 25:728–732

    CAS  Google Scholar 

  • Huggins CB (1931) The formation of bone under the influence of epithelium of the urinary tract. Arch Surg 22:377–408

    Google Scholar 

  • Koch FW, Naegele M, von Deimling U, Messier HH, Wagner U (1992) Das Verhalten des Knochens auf künstlicher Matrix ohne biomechanischen Einfluss. In: Pesch HJ, Stöss B, Kummer B (Hrsg) Osteologie aktuell VII 363–367. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Koch FW, Messier HH, von Deimling U, Kaden B, Rüther W (1994) Die In-vivo-Transformation der induzierbaren Osteoprogenitorzelle zum Osteoblasten in alkalischer Biokeramik. In: Reiser M, Heuck A, Münzenberg KJ, Kummer B (Hrsg) Osteologie aktuell VIII: 457–464. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Koch FW, Seidel M, Peters K (2003) Die klinische Wertigkeit von periartikulärer ektoper Ossifikation und reaktiver florider Periostitis nach Kniegelenksendoprothetik. Eine retrospektive Studie an 331 Fällen. Orthopädische Praxis 39:26–32

    Google Scholar 

  • Koch FW, Bastian P, Seidel M, Peters KM (2003) Neue pathogenetische Aspekte der ektopen Ossifikation. Tierexperimentelle Befunde und mögliche therapeutische Konsequenzen. MOT 5(123):31–48

    Google Scholar 

  • Lash JW (1963) Ability of embryonic mesonephros explants to form cartilage. Devel Biol 6:219–232

    Article  Google Scholar 

  • Lash JW, Holtzer S, Holtzer H (1957) Aspects of Cartilage Induction. Exp Cell Res 13:292–303

    Article  PubMed  CAS  Google Scholar 

  • Levander G, Willstaedt H (1946) Alcohol-Soluble Osteogenetic Substance from Bone Marrow. Nature 157:587

    CAS  Google Scholar 

  • Liek E (1906) Experimenteller Beitrag zur Frage der heteroplastischen Knochenbildung. Arch f klin Chir 80:279–310

    Google Scholar 

  • Liek E (1908) Ein weiterer Beitrag zur heteroplastischen Knochenbildung in Nieren. Arch f klin Chir 85:118–138

    Google Scholar 

  • Mebius J (1924) Die formale Genese der Knochenbildung in Bauchnarben. Virchows Arch Pathol Anat 248:252–284

    Google Scholar 

  • Nomura S, Wills AJ, Edwards DR, Heath JK, Hogan BLM (1988) Development expression of 2 ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ Hybridisation. J Cell Biol 106:441–450

    Article  PubMed  CAS  Google Scholar 

  • O’Rahilly R, Gardner E (1976) The embryology of bone and bones. In: Ackermann LA, Spjut HJ, Abell MR (eds) Bone and joints, chap 1. Williams and Wilkins, Baltimore, pp 1–15

    Google Scholar 

  • Ott VR (1953) Über die Spondylosis hyperostotica. Schweiz med Wschr 83:790–799

    PubMed  CAS  Google Scholar 

  • Owen ME, Cave J, Joyner CJ (1987) Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F. J Cell Science 87:731–738

    PubMed  Google Scholar 

  • Pereira RC, Economides AN, Canalis E (2000) Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. Endocrinology 141:4558–4563

    Article  PubMed  CAS  Google Scholar 

  • Plasmans CMT, Jap PHK, Kuipers W, Slooff TJJH (1980) Influence of a diphosphonate on the cellular aspect of young bone tissue. Calc Tiss Int 32:247–256

    CAS  Google Scholar 

  • Poscharissky JF (1905) Über heteroplastische Knochenbildung. Beitr z path Anat u z allg Path 38:135–176

    Google Scholar 

  • Post R, Heiple KG, Chase SW, Herndon CH (1966) Bone grafts in diffusion chambers. Clin Orthop 44: 265–270

    PubMed  CAS  Google Scholar 

  • Reddi AH, Huggins CB (1972) Influence of geometry of transplanted tooth and bone on transformation of fibroblasts. Proc Soc Exp Biol Med 143:634–637

    Google Scholar 

  • Reddi AH (1981) Cell biology and biochemistry of en-dochondral bone development. Cell Res 1:209–226

    CAS  Google Scholar 

  • Reddi AH (1985) Regulation of bone differentiation by local and systemic factors. Bone and Mineral Res 3:24–47

    Google Scholar 

  • Reddi AH (2001) Bone morphogenetic proteins from basic science to clinical applications. J Bone Joint Surg Am 83(Suppl):Sl–6

    Google Scholar 

  • Ritter MA, Vaughan RB (1977) Ectopic ossification after total hip arthroplasty. Predisposing factors, frequency, and effects on result. J Bone Joint Surg 59A:345–351

    Google Scholar 

  • Roberts AB, Sporn MB (1985) Transforming growth factors. Cancer Surv 4:683–705

    PubMed  CAS  Google Scholar 

  • Roth SI, Stowell RE, Helweg EB (1963) Cutaneous ossification. Report of 120 cases and review of the literature. Arch Pathol 76:44–54

    PubMed  CAS  Google Scholar 

  • Rüther W (1987) Wirkungen von Diphosphonaten auf die Entwicklung der matrixinduzierten, ektopen Osteogenese. Habilitationsschrift. Medizinische Fakultät der Universität Bonn

    Google Scholar 

  • Sato K, Urist MR (1984) Bone morphogenetic protein-induced cartilage developement in tissue culture. Clin Orthop 183:180–187

    PubMed  Google Scholar 

  • Scherft JP (1968) The ultrastructure of the organic matrix of calcified cartilage and bone in embryonic mouse radii. J Ultrastruct Res 23:333–343

    Article  Google Scholar 

  • Schulz A, Jundt G (1988) Differenzierung des matrix-bildenden Bindegewebes. Verh Dtsch Ges Path 72:86–101

    CAS  Google Scholar 

  • Tonna EA (1966) A study of osteocyt formation and distribution in aging mice complemented with 3H-proline autoradiography. J Gerontol 21:124–129

    PubMed  CAS  Google Scholar 

  • Urist MR, Silverman BF, Buring K, Dubec FL, Rosenberg JM (1967) The bone induction principle. Clin Orthop 53:243–283

    PubMed  CAS  Google Scholar 

  • Urist MR, Dowell TR (1968) The inductive substratum for osteogenesis in pelletts of particulate bone matrix. Clin Orthop 61:61–78

    PubMed  CAS  Google Scholar 

  • Urist MR, Granstein R, Nogami H, Svenson L, Murphy R (1977) Transmembrane bone morphogenesis across multiple-walled chambers: new evidence of a diffusible bone morphogenetic property. Arch Surg 112:612–619

    PubMed  CAS  Google Scholar 

  • Urist MR, Mikulski AJ (1979) A soluble bone morphogenetic protein extracted from bone matrix with a mixed aqueous non-aqueous solvent. Proc Soc Exp Biol Med 162:48–53

    PubMed  CAS  Google Scholar 

  • Urist MR, Mikulski AJ, Lietze A (1979) Solubilized and insolubilized bone morphogenetic protein. Proc Nat Acad Sci 76:1828–1832

    PubMed  CAS  Google Scholar 

  • Urist MR (1980) Fundamental and clinical bone physiology. In: Urist MR (ed). pp 331–368

    Google Scholar 

  • Urist MR, Delange RJ, Finerman RJ (1983 a) Bone cell differentiation and growth factors. Science 220:680–686

    PubMed  CAS  Google Scholar 

  • Urist MR, Sato K, Brownell AG, Malinin TI, Lietze A, Huo YK, Prolo DJ, Oklund S (1983b) Human bone morphogenetic protein (hBMP). Proc Soc Exp Biol Med 173:194–199

    PubMed  CAS  Google Scholar 

  • Urist MR, Huo YK, Brownell AG, Hohl WM, Buyske J, Lietze A, Tempst P, Hunkapiller M, DeLange RJ (1984) Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc Natl Acad Sci 81:371–375

    PubMed  CAS  Google Scholar 

  • Walker DG (1975) Control of bone resorption by hematopoietic tissue. The induction and reversal of congenital osteopetrosis in mice through use of bone marrow and splenic transplants. J Exp Med 142:651

    Article  PubMed  CAS  Google Scholar 

  • Wientroup S, Reddi AH (1988) Influence of irradiation on the osteoinductive potential of demineralized bone matrix. Calcif Tiss Int 42:255–260

    Google Scholar 

  • Yoon K, Buenaga R, Rodan GA (1987) Tissue specifity and developmental expression of rat osteopontin. Biochem Biophys Res Comm 148:1129–1136

    Article  PubMed  CAS  Google Scholar 

  • Young RW (1962) Cell proliferation and specialization during endochondral osteogenesis in young rats. J Cell Biol 14:357–370

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Orthopädische Abteilung, St. Josef-Hospital, Hospitalstrasse 45, 53840, Troisdorf

    Prof. Dr. med. F. W. Koch

  2. Urologische Abteilung, St. Josef-Hospital, Hospitalstrasse 45, 53840, Troisdorf

    Dr. med. P. Bastian

  3. Medizinische Universitäts-Poliklinik, Rheinische Friedrich-Wilhelms-Universität, Wilhelmstrasse 35 - 37, 53111, Bonn

    Priv.-Doz. Dr. med. M. Seidel

Authors
  1. Prof. Dr. med. F. W. Koch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. med. P. Bastian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Priv.-Doz. Dr. med. M. Seidel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Rhein-Sieg-Klinik, Abteilung für Orthopädie und Osteologie, Höhenstraße 30, 51588, Nümbrecht

    Klaus M. Peters

  2. Klinik und Poliklinik für Orthopädie, Universität zu Köln, Joseph-Stelzmann-Straße 24, 50931, Köln

    Dietmar P. König

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Steinkopff Verlag Darmstadt

About this chapter

Cite this chapter

Koch, F.W., Bastian, P., Seidel, M. (2006). Heterotope Ossifikationen — experimentelle und klinische Aspekte. In: Peters, K.M., König, D.P. (eds) Fortbildung Osteologie 1. Fortbildung Osteologie, vol 1. Steinkopff. https://doi.org/10.1007/3-7985-1602-2_19

Download citation

  • DOI: https://doi.org/10.1007/3-7985-1602-2_19

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1601-4

  • Online ISBN: 978-3-7985-1602-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation